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A kind of preparation method of hemoperfusion resin adsorbent for removing bilirubin

A resin adsorption and blood perfusion technology, which is applied in the fields of blood circulation treatment, chemical instruments and methods, suction instruments, etc., can solve the problems of complex preparation process, high cost, low product adsorption efficiency, etc., and achieves low operation difficulty, low difficulty, Easy-to-control effects

Active Publication Date: 2019-01-11
上海宏存新材料科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Aiming at the deficiencies in the existing bilirubin perfusion adsorbent technology, such as complicated preparation process, high cost, and low product adsorption efficiency, the purpose of the present invention is to provide a preparation method of hemoperfusion resin adsorbent for bilirubin removal

Method used

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  • A kind of preparation method of hemoperfusion resin adsorbent for removing bilirubin
  • A kind of preparation method of hemoperfusion resin adsorbent for removing bilirubin

Examples

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Embodiment 1

[0030] (1) Select cross-linking degree 4~20%, total average pore diameter 10~100nm, particle diameter 30~80 purpose cross-linked polymethyl methacrylate as the carrier of polymer resin type adsorbent for bilirubin removal;

[0031] (2) Graft spacer arms on the surface of the selected resin adsorbent carrier:

[0032] Weigh 100g of the above-mentioned resin adsorbent carrier, wash it and place it in a three-necked flask with a thermometer and a stirrer, add 200g of dimethylformamide to swell for 1 hour, then add 200g of hexamethylenediamine for amination, and heat up to 120°C , stirring at 300 rev / min at a constant temperature for 12 hours and then discharging, washing and filtering with deionized water to obtain a resin adsorbent grafted with a spacer arm;

[0033] (3) quaternization of the spacer arm end grafted on the above-mentioned resin adsorbent:

[0034] Put the resin adsorbent grafted with the spacer arm obtained in step (2) into a three-necked flask with a stirrer an...

Embodiment 2

[0038]The method and steps of this embodiment are basically the same as in Example 1, the difference is that in step (1): 4-20% of the cross-linking degree is selected, the total average pore size is 10-100 nm, and the particle size is 30-80 mesh cross-linked polyformaldehyde Glycidyl acrylate was used as the carrier of polymer resin-type adsorbent for bilirubin removal.

Embodiment 3

[0040] The method and steps of this example are basically the same as those in Example 1, except that in step (2): 200 g of dimethylformamide is added to swell for 1 hour, and then 300 g of tetraethylenepentamine is added for amination.

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Abstract

The invention relates to a preparation method of a hemoperfusion resin adsorbent for bilirubin removal. Crosslinked acrylate polymer microspheres 4-20% in crosslinking degree, 10-100 nm in total average pore size and 30-80 mesh in particle size are used as a support, spacers of certain length are grafted first through amination, tail ends of the spacers are then quaternized, and the adsorbent is finally enveloped with poly-Beta-hydroxyethyl methacrylate. The preparation method provided herein is less difficult and easy to control and has clear mechanism; the hemoperfusion resin adsorbent for bilirubin removal prepared herein has good biocompatibility, high selective absorption rate for bilirubin and applicable to the field of hemoperfusion treatment.

Description

technical field [0001] The invention relates to a preparation method of a hemoperfusion adsorption material in the field of biomedical materials, in particular to a preparation method of a hemoperfusion resin adsorbent for removing bilirubin. Background technique [0002] Bilirubin (Bilirubin, BR) is a kind of bile pigment, which is orange-yellow and is the main metabolite of hemoglobin in the body. Bilirubin is a non-polar fat-soluble substance that is insoluble in water but has a high affinity for plasma albumin. Bilirubin in normal human serum, one is conjugated bilirubin (or direct bilirubin), which is combined with glucuronic acid or other substances through the action of endoplasmic reticulum in liver cells; the other is free bilirubin Bilirubin (or indirect bilirubin), which comes from the destruction of red blood cells, is mainly combined with albumin and transported in plasma. There is very little bilirubin in normal human plasma. When the body produces too much b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/36
CPCA61M1/3679A61M2205/02A61M2207/00B01J20/267
Inventor 孙康王解兵
Owner 上海宏存新材料科技有限公司
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