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Maleic acid timolol preparation for treating infant superficial hemangioma and application of maleic acid timolol preparation

A technology of timolol maleate and hemangioma, applied in the field of timolol maleate preparations, can solve the problems of inability to play a long-term effect, inability to adhere, dry skin, etc., and achieves the promotion of skin wound healing , Prolonged adhesion time, the effect of promoting wound healing

Inactive Publication Date: 2016-12-14
北京中燕瑞康医药科技开发有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the course of clinical practice, it is found that it is extremely inconvenient to use this method of administration. The eye drops evaporate quickly to dryness in a short period of time. , unable to play a curative effect, resulting in waste of drugs; long-term use can also lead to dry skin, peeling
In addition, due to the poor cooperation of infants, it is extremely inconvenient to administer drugs in this way

Method used

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  • Maleic acid timolol preparation for treating infant superficial hemangioma and application of maleic acid timolol preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Purpose of the experiment

[0027] Timolol maleate has a therapeutic effect on superficial hemangioma in infants. However, the liquid reagents of the eye drop formulations currently on the domestic market cannot be well attached to the patient's skin during use, and the action time is short. Patient compliance is poor when using gauze or cotton pads as an adjunct. The imported ointment forms a powder after drying and cannot function well. In this experiment, sodium hyaluronate and timolol maleate eye drops were used to quickly make colloid products, and the therapeutic effects were compared with imported ointment products.

[0028] 2. Experimental materials

[0029] Timolol Maleate Eye Drops (Wuhan Wujing Pharmaceutical Co., Ltd., National Drug Accreditation H42021078, specification 5ml: 25mg);

[0030] Sodium hyaluronate (molecular weight 1000kDa, Bloomage Freda Biomedical Co., Ltd., in line with the State Food and Drug Administration sodium hyaluronate standard...

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Abstract

The invention provides a maleic acid timolol preparation for treating infant superficial hemangioma and application of the maleic acid timolol preparation. The maleic acid timolol preparation adopts water as a dispersing medium and comprises the following components by mass percent with the total percent of 100%: 0.1-1% of maleic acid timolol and 0.5-2% of hyaluronic acid or hyaluronate. The maleic acid timolol preparation provided by the invention is relatively good in viscosity and convenient for medical operators to rub on patients, a film can be formed on the skin surface, the adhesion time is greatly prolonged, and active components can play roles continuously; the maleic acid timolol preparation has a moisturizing function and is not dried within a short time, so that the skin surface can be kept in a wet state for a long time; as the keratoderma of an infant is thin and the water content is higher than that of an adult, the moisturizing function is particularly important for infant skin, however, hyaluronic acid or hyaluronate is not used in infant preparation dressing yet at present; in addition, application of hyaluronic acid or hyaluronate to the dressing shows by accident that the function of promoting wound healing of infant skin can be achieved.

Description

technical field [0001] The invention relates to a timolol maleate preparation for treating infantile superficial hemangioma. Background technique [0002] Infantile hemangiomas are more common in premature infants, small-sized infants, or multiple pregnancy infants. Among them, the face and neck are the most frequent sites of hemangiomas, followed by the extremities and trunk. Hemangiomas in infants are in the period of rapid proliferation when they are 4 to 10 months old. Hemangiomas in the proliferative stage are prone to ulceration, bleeding, infection, and often leave scars. If they are located on the eyelids and around the orbit, they may cause severe damage to vision. If they are located in the trachea, they may cause symptoms of compression. resulting in restricted breathing. Therefore, active intervention in the proliferative phase of hemangioma can effectively avoid complications. In addition to hormonal therapy, laser therapy, and surgical resection, prior art ha...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/5377A61K47/36A61P35/00A61P17/02A61P17/00
CPCA61K9/06A61K9/0014A61K31/5377A61K47/36
Inventor 燕姿辰
Owner 北京中燕瑞康医药科技开发有限公司
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