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Kanamycin sulfate eye drops and preparation method thereof

A technology of kanamycin sulfate and eye drops, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, active ingredients of anhydride/acid/halide, etc., can solve Escherichia, Klebsiella, Proteus, Enterobacter, Shigella, Salmonella, Citrobacter, Providencia, Yersinia, Pseudomonas aeruginosa, etc.

Inactive Publication Date: 2016-12-07
ANHUI AIKEER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Shigella, Salmonella, Citrobacter, Providencia, Yale Mori bacteria, etc. have good effects; Influenza bacilli, Brucella, meningococcus, Neisseria gonorrhoeae, etc. are also mostly sensitive to this product, and are ineffective against Pseudomonas aeruginosa

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A kind of kanamycin sulfate eye drop, its raw material is as follows by weight: kanamycin sulfate 4 grams, vitamin B6 0.3 gram, hyaluronic acid sodium 2 grams, taurine 1 gram, sodium chloride 0.8 gram, 0.2 grams of boric acid, 0.3 grams of disodium edetate, and 80 milliliters of distilled water.

[0018] The sodium hyaluronate is powdered sodium hyaluronate, and the powder mesh is 1000 mesh.

[0019] A preparation method of kanamycin sulfate eye drops, comprising the steps of:

[0020] S1: Prepare two clean and sterile test tubes, add kanamycin sulfate into the test tube, and pour half of the distilled water into the test tube at the same time, shake vigorously to make the kanamycin sulfate and distilled water fully mixed, place the test tube The water is heated by a water bath, and the temperature of the water bath is controlled between 45-55 degrees Celsius;

[0021] S2: Put vitamin B6, sodium hyaluronate, taurine, sodium chloride, boric acid, disodium edetate and t...

Embodiment 2

[0027] A kind of kanamycin sulfate eye drop, its raw material is as follows by weight: 5 grams of kanamycin sulfate, 0.4 gram of vitamin B6, 2.5 grams of sodium hyaluronate, 1.3 grams of taurine, 0.9 grams of sodium chloride, 0.3 g of boric acid, 0.4 g of disodium edetate, and 90 ml of distilled water.

[0028] The sodium hyaluronate is powdered sodium hyaluronate, and the powder mesh is 1000 mesh.

[0029] A preparation method of kanamycin sulfate eye drops, comprising the steps of:

[0030] S1: Prepare two clean and sterile test tubes, add kanamycin sulfate into the test tube, and pour half of the distilled water into the test tube at the same time, shake vigorously to make the kanamycin sulfate and distilled water fully mixed, place the test tube The water is heated by a water bath, and the temperature of the water bath is controlled between 45-55 degrees Celsius;

[0031] S2: Put vitamin B6, sodium hyaluronate, taurine, sodium chloride, boric acid, disodium edetate and t...

Embodiment 3

[0037] A kind of kanamycin sulfate eye drop, its raw material is as follows by weight: kanamycin sulfate 6 grams, vitamin B6 0.5 gram, hyaluronic acid sodium 3 grams, taurine 1.5 grams, sodium chloride 1 gram, 0.4 grams of boric acid, 0.5 grams of disodium edetate, and 100 milliliters of distilled water.

[0038] The sodium hyaluronate is powdered sodium hyaluronate, and the powder mesh is 1000 mesh.

[0039] A preparation method of kanamycin sulfate eye drops, comprising the steps of:

[0040] S1: Prepare two clean and sterile test tubes, add kanamycin sulfate into the test tube, and pour half of the distilled water into the test tube at the same time, shake vigorously to make the kanamycin sulfate and distilled water fully mixed, place the test tube The water is heated by a water bath, and the temperature of the water bath is controlled between 45-55 degrees Celsius;

[0041] S2: Put vitamin B6, sodium hyaluronate, taurine, sodium chloride, boric acid, disodium edetate and...

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PUM

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Abstract

The invention discloses kanamycin sulfate eye drops which comprise the following raw materials in grams by weight: 4-6g of kanamycin sulfate, 0.3-0.5g of vitamin B6, 2-3g of sodium hyaluronate, 1-1.5g of taurine, 0.8-1g of sodium chloride, 0.2-0.4g of boric acid, 0.3-0.5g of ethylene diamine tetraacetic acid and 80-100ml of distilled water. According to the kanamycin sulfate eye drops and the preparation method thereof provided by the invention, due to addition of kanamycin sulfate, multiple raw materials are mixed in a stepped mixing manner, so that the mixing effect is good, and the eye drops are applicable to treatment of infections such as conjunctivitis, keratitis, dacryocystitis, blepharitis, meibomiantis and the like caused by bacteria such as sensitive Escherichia coli, klebsiella, proteus, neisseria gonorrhoeae, staphylococcus and the like.

Description

technical field [0001] The invention relates to the technical field of eye drops, in particular to a kanamycin sulfate eye drop and a preparation method thereof. Background technique [0002] Eye drops are medicines for the treatment of eye diseases. There are many types of eye drops according to their functions, such as steroids, antibiotics, antihistamines, β-blockers, non-steroidal anti-inflammatory painkillers, etc. Kanamycin is an aminoglycoside antibiotic. For most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Shigella, Salmonella, Citrobacter, Providencia, Yale Mori bacteria, etc. have a good effect; influenza bacilli, Brucella, meningococcus, gonorrhea, etc. are also mostly sensitive to this product, and are ineffective against Pseudomonas aeruginosa. It also has a certain effect on methicillin-sensitive strains of Staphylococcus and Mycobacterium tuberculosis, and other Gram-positive bacteria such as hemolytic streptococ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/22A61K31/7036A61K9/08A61P31/04A61P27/02
CPCA61K9/0048A61K9/08A61K31/185A61K31/4415A61K31/7036A61K31/728A61K33/14A61K33/22A61K47/183A61K2300/00Y02A50/30
Inventor 葛长城王殿阔吴磊
Owner ANHUI AIKEER PHARMA CO LTD
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