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Probucol and lovastatin compound composite and preparation method

A technology of lovastatin and probucol, which is applied in the field of medicine, can solve the problems of excessive dosage of excipients for tablet compression, reduce the cost of excipients and packaging, and high packaging cost, and achieve the effects of improving compliance, high effective ratio, and convenient administration

Inactive Publication Date: 2016-12-07
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Since a single drug often cannot achieve the desired curative effect, two or more antihypertensive drugs are often used in combination in clinical practice to achieve better curative effect; however, the combination of two or more single antihypertensive drugs, It is inconvenient to take, and the amount of excipients for single tablet compression is relatively large, and the packaging cost is high. Therefore, making two or more antihypertensive drugs into a compound preparation is not only convenient for medication, but also reduces the cost of excipients and packaging, which is conducive to mass production.

Method used

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  • Probucol and lovastatin compound composite and preparation method
  • Probucol and lovastatin compound composite and preparation method
  • Probucol and lovastatin compound composite and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound composition of probucol and lovastatin, the components and parts by weight of the compound composition include: 15 parts of probucol, 2 parts of lovastatin, 20 parts of lactose, 1 part of polysorbate, carboxymethyl 20 parts of sodium starch, 1 part of magnesium stearate.

[0028] A preparation method of probucol lovastatin compound composition, comprising the steps of:

[0029] 1) Prepare materials, prepare materials according to the components and parts by weight of a probucol and lovastatin compound composition; wherein probucol and lovastatin are respectively pulverized through a 120 mesh sieve, lactose, polysorbate, carboxylate Sodium starch glycolate and magnesium stearate were pulverized respectively through an 80-mesh sieve;

[0030] 2) For granulation, mix the materials prepared in step 1) evenly, and wet granulate;

[0031] 3) Grain sizing, pass the granules obtained in step 2) through a 20-mesh sieve for sizing;

[0032] 4) Tablet pressing, mix t...

Embodiment 2

[0035] A compound composition of probucol and lovastatin, the components and parts by weight of the compound composition include: 20 parts of probucol, 3 parts of lovastatin, 30 parts of compressible starch, polyoxyethylene fatty acid ester 3 parts, 30 parts of cross-linked polyvinylpyrrolidone, 3 parts of micronized silica gel.

[0036] A preparation method of probucol lovastatin compound composition, comprising the steps of:

[0037] 1) Prepare materials, prepare materials according to the components and parts by weight of a probucol-lovastatin compound composition; wherein probucol and lovastatin are respectively pulverized through a 120-mesh sieve, compressible starch, polyoxygen Ethylene fatty acid ester, cross-linked polyvinylpyrrolidone, and micropowder silica gel are respectively pulverized and passed through an 80-mesh sieve;

[0038] 2) For granulation, mix the materials prepared in step 1) evenly, and wet granulate;

[0039] 3) Grain sizing, pass the granules obta...

Embodiment 3

[0043] A compound composition of probucol and lovastatin, the components and parts by weight of the compound composition include: 17 parts of probucol, 1 part of lovastatin, 25 parts of microcrystalline cellulose, polyoxyethylene-polyoxyethylene 2 parts of propylene copolymer, 25 parts of croscarmellose sodium, and 2 parts of talcum powder.

[0044] A preparation method of probucol lovastatin compound composition, comprising the steps of:

[0045] 1) Prepare materials, prepare materials according to the components and parts by weight of a probucol-lovastatin compound composition; wherein probucol and lovastatin are respectively pulverized through a 120-mesh sieve, microcrystalline cellulose, polyoxygen Ethylene-polyoxypropylene copolymer, croscarmellose sodium, and talcum powder were pulverized respectively through an 80-mesh sieve;

[0046] 2) For granulation, mix the materials prepared in step 1) evenly, and wet granulate;

[0047] 3) Grain sizing, pass the granules obtain...

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Abstract

The invention discloses probucol and lovastatin compound composite and a preparation method. The compound composite comprises, by weight, 15-20 parts of probucol, 1-3 parts of lovastatin, 20-30 parts of diluent, 1-3 parts of surfactant, 20-30 parts of disintegrant and 1-3 parts of lubricant. The preparation method includes material preparation, granulation, granule preparation and tableting. Probucol and lovastatin are combined organically, consumption of pharmaceutic adjuvants is reduced to the uttermost degree, and the compound composite can be used for treating hyperlipidemia. The compound composite is high in effective drug proportion, convenient to take, capable of improving compliance of patients and beneficial to reduction of medicine price and industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a compound composition of probucol and lovastatin and a preparation method thereof. Background technique [0002] Blood lipids refer to the content of adipose elements such as free fatty acids, phospholipids, sterols and triglycerides in human plasma. The healthy value of blood lipid content in blood plasma is generally below 130mg / dl (milligrams per deciliter); any medically called blood fat element exceeding the standard above 160mg / dl is hyperlipidemia. Hyperlipidemia, high blood pressure, and high blood sugar are called "three highs" together, known as the "invisible killer" of human health, and are one of the main diseases that require health stewards to manage chronic diseases. The damage of the disease to the body is hidden, gradual, progressive and systemic. Its direct damage is to accelerate systemic atherosclerosis, because vital organs of the whole body re...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P3/06A61K31/10
CPCA61K31/10A61K31/366A61K2300/00
Inventor 陈坤赵明媚
Owner LIAOCHENG UNIV
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