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A kind of felodipine isosorbide dinitrate compound sustained-release tablet and preparation method

A technology of isosorbide dinitrate and compound sustained-release tablets, which is applied in the field of medicine, can solve the problems of excessive dosage of excipients for single-pressing tablets, patients' easy to miss medication, and reduce patient compliance, so as to achieve easy scale-up production and facilitate taking , the effect of a high effective ratio of the drug

Active Publication Date: 2018-12-25
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combined application of two or more antihypertensive drugs can achieve better antihypertensive effect; hypertension treatment requires long-term medication, and it is necessary to take multiple drugs at a time or multiple times a day, which makes it easy for patients to miss drugs and thus reduce patient compliance
Moreover, the amount of excipients for tablet compression is relatively large, and the packaging cost is high. Therefore, how to reduce the type and frequency of medication to improve patient compliance is the focus of current research.

Method used

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  • A kind of felodipine isosorbide dinitrate compound sustained-release tablet and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A felodipine isosorbide dinitrate compound slow-release tablet, the compound slow-release tablet includes a felodipine quick-release part and an isosorbide dinitrate slow-release part, wherein the components and parts by weight of the felodipine quick-release part include 5 parts of felodipine, 15 parts of starch, 0.1 part of sucrose ester, 10 parts of sodium carboxymethyl starch, 0.5 part of magnesium stearate, the components and parts by weight of isosorbide dinitrate slow-release part include isosorbide dinitrate 3 20 parts of sodium alginate, 10 parts of starch, 0.1 part of sorbitan fatty acid, and 0.3~0.8 parts of micronized silica gel.

[0032] A preparation method for felodipine isosorbide dinitrate compound sustained-release tablet, comprising the steps of:

[0033] 1) Prepare materials, prepare materials according to the components and parts by weight of the Felodipine Isosorbide Dinitrate Compound Sustained Release Tablet, wherein Felodipine is pulverized thro...

Embodiment 2

[0039] A felodipine isosorbide dinitrate compound slow-release tablet, the compound slow-release tablet includes a felodipine quick-release part and an isosorbide dinitrate slow-release part, wherein the components and parts by weight of the felodipine quick-release part include 10 parts of felodipine, 10 parts of starch, 10 parts of microcrystalline cellulose, 0.2 parts of sorbitan fatty acid, 0.3 parts of polysorbate, 15 parts of low-substituted hydroxypropyl cellulose, 1 part of micropowder silica gel, slow-release isosorbide dinitrate Partial components and parts by weight include 8 parts of isosorbide dinitrate, 10 parts of potassium alginate, 20 parts of chitosan, 15 parts of mannitol, 0.5 part of polysorbate, 0.3 part of micronized silica gel, and 0.5 part of talcum powder.

[0040] A preparation method for felodipine isosorbide dinitrate compound sustained-release tablet, comprising the steps of:

[0041] 1) Prepare materials, prepare materials according to the compone...

Embodiment 3

[0047] A felodipine isosorbide dinitrate compound slow-release tablet, the compound slow-release tablet includes a felodipine quick-release part and an isosorbide dinitrate slow-release part, wherein the components and parts by weight of the felodipine quick-release part include 8 parts of felodipine, 8 parts of microcrystalline cellulose, 10 parts of mannitol, 0.3 parts of polysorbate, 5 parts of low-substituted hydroxypropyl cellulose, 7 parts of cross-linked polyvinylpyrrolidone, 0.3 parts of micropowder silica gel, talcum powder 0.4 parts, the components and parts by weight of the isosorbide dinitrate slow-release part include 5 parts of isosorbide dinitrate, 24 parts of chitosan, 3 parts of starch, 10 parts of microcrystalline cellulose, 0.4 parts of sorbitan fatty acid, hard 0.6 parts of magnesium fatty acid.

[0048] A preparation method for felodipine isosorbide dinitrate compound sustained-release tablet, comprising the steps of:

[0049] 1) Prepare materials, prepar...

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Abstract

The invention discloses a felodipine and isosorbide dinitrate compound sustained-release tablet, and belongs to the technical field of medicines. The compound sustained-release tablet consists of a felodipine sustained-release part and an isosorbide dinitrate sustained-release part, wherein the felodipine sustained-release part consists of the following components: felodipine, a diluent, a surfactant, a disintegrant and a lubricant; and the isosorbide dinitrate sustained-release part consists of the following components: isosorbide dinitrate, a sustained-release material, a diluent, a surfactant and alubricant. A preparation method comprises steps of preparing materials, preparing granules, straightening the granules and tabletting the granules. The compound sustained-release tablet provided by the invention, by organically combining the felodipine and the isosorbide dinitrate, can reduce the dosage of pharmaceutical adjuvants to the greatest extent and increase the effective proportions of medicines. With the application of the sustained-release tablet provided by the invention, the durable and slow release of the medicines is achieved, and the sustained-release tablet is stable in blood concentration and light in fluctuation, so that the sustained-release tablet can reduce an administration frequency, bring about benefits for patients to take the sustained-release tablet and improve the compliance of the patients.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a compound sustained-release tablet of felodipine isosorbide dinitrate and a preparation method thereof. Background technique [0002] Hypertension has become the "No. 1 killer" of Chinese people's health. There are currently 160 million hypertensive patients in my country, so it is also called "China's No. 1 disease". Suffering from high blood pressure, this "fuse" can cause a variety of complications, and at some point it will ignite a certain "explosive package" in the human body, leading to a "big explosion" that destroys health and endangers life, such as Coronary heart disease, myocardial infarction, cerebrovascular disease, renal failure, etc. Among them, cerebrovascular disease is the most easily ignited and most harmful "explosive kit". Among uncured hypertensive patients in China, 70-80% died of cerebrovascular disease, 1-5% died of coronary heart disease, and 5-10%...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61K9/22A61K47/36A61K47/38A61P9/12A61K31/34
CPCA61K9/2059A61K9/209A61K31/34A61K31/4422
Inventor 陈坤赵明媚
Owner LIAOCHENG UNIV
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