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Metformin and acipimox compound composition and preparation method thereof

A technology of metformin and acipimox, which is applied in the field of medicine, can solve the problems of excessive dosage of tablet excipients, high packaging costs, inconvenient administration, etc., and achieve the effects of lower drug prices, convenient administration, and reduced industrial production

Inactive Publication Date: 2016-05-25
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the improvement of living conditions of modern people, most diabetic patients are accompanied by hyperlipidemia. Since a single drug is often unable to achieve the desired curative effect, clinically, hypoglycemic drugs and blood lipid-lowering drugs are often used in combination to achieve better curative effect. However, it is inconvenient to take two or more single-prescription drugs in combination, and the amount of excipients for tablet compression is relatively large, and the packaging cost is high. Therefore, making two or more than two drugs into a compound preparation is not only convenient for medication, Moreover, it reduces the cost of auxiliary materials and packaging, which is conducive to reducing drug prices and industrial production

Method used

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  • Metformin and acipimox compound composition and preparation method thereof
  • Metformin and acipimox compound composition and preparation method thereof
  • Metformin and acipimox compound composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound composition of metformin and acipimox, the components and parts by weight of the composition include: 5 parts of metformin, 5 parts of acipimox, 5 parts of starch, 0.3 parts of sucrose ester, and 10 parts of sodium carboxymethyl starch , 0.5 part of magnesium stearate.

[0028] A preparation method of a metformin-acipimox compound composition, comprising the steps of:

[0029] 1) preparing materials, preparing materials according to the components and parts by weight of the metformin-acipimox compound composition, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, starch, sucrose ester, Sodium carboxymethyl starch and magnesium stearate were pulverized respectively through a 100-mesh sieve;

[0030] 2) granulation, mixing the materials prepared in step 1) evenly, and wet granulation, the binder used is alcohol with a mass concentration of 60% to 70%, and the amount of alcohol is 0.5 times the weight of ...

Embodiment 3

[0042] A compound composition of metformin and acipimox, the components and parts by weight of the composition include: 8 parts of metformin, 8 parts of acipimus, 3 parts of mannitol, 3 parts of starch, 0.4 parts of polysorbate, 14 parts of sodium carboxymethyl cellulose, 0.7 parts of talcum powder.

[0043] A preparation method of a metformin-acipimox compound composition, comprising the steps of:

[0044] 1) Prepare materials, prepare materials according to the components and parts by weight of the metformin-acipimox compound composition, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, mannitol, starch, Polysorbate, croscarmellose sodium, and talcum powder were pulverized respectively through a 100-mesh sieve;

[0045] 2) granulation, mixing the materials prepared in step 1) evenly, and wet granulation, the binder used is alcohol with a mass concentration of 60% to 70%, and the amount of alcohol is 0.5 times the wei...

Embodiment 4

[0050] Inspection of the friability of the compound composition of the present invention

[0051] Check according to "Chinese Pharmacopoeia" 2010 edition (two) appendix XG tablet friability inspection method.

[0052] Apparatus used: Friability tester.

[0053] Method: Take 10 pieces, blow off the falling powder with a hair dryer, weigh them accurately, put them in a cylinder, and rotate them 100 times. Take it out, remove the powder in the same way, and weigh it accurately. The weight loss should not exceed 1%, and no broken, cracked or crushed tablets should be detected. This test is generally only done once. If the weight loss exceeds 1%, it should be re-inspected twice, and the average weight loss of the three times should not exceed 1%, and broken, cracked and crushed tablets should not be detected.

[0054] Result: The samples obtained in Examples 1-3 of the present invention all meet the requirements after being checked by the friability test.

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Abstract

The invention discloses metformin and acipimox compound composition and a preparation method thereof. The composition comprises components in parts by weight as follows: 5-10 parts of metformin, 5-10 parts of acipimox, 5-8 parts of a diluent, 0.3-0.6 parts of a surfactant, 10-15 parts of a disintegrating agent and 0.5-0.8 parts of a lubricant. The preparation method comprises steps as follows: material preparation, granulation, size grading and tabletting. The compound composite can treat hyperglycemia and hyperlipidemia; the curative effect of the medicine can be improved, the effective proportion of the medicine is high, the medicine is convenient to take, and compliance of patients is improved. The auxiliary and packaging costs of the compound composition are reduced, medicine price is reduced, and industrial production is facilitated.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a compound composition of metformin and acipimox and a preparation method thereof. Background technique [0002] Metformin, English name: Metformin, Chinese aliases: Metformin, Metformin Hydrochloride, Metformin, Metformin Hydrochloride, Metformin, Hypoglycemic, Rickose, Medicom. Main purposes: 1) For type Ⅱ diabetes mellitus, especially obese type Ⅱ diabetes mellitus, which is ineffective for simple diet control and physical exercise. 2) Combining this product with insulin can reduce the dosage of insulin and prevent hypoglycemia. 3) It can be used in combination with xanthyl urea drugs for blood sugar, which has a synergistic effect. Mechanism of action: ① Promote the utilization of glucose by surrounding tissue cells (muscle, etc.); ② Inhibit hepatic gluconeogenesis, thereby reducing the output of glycogen; ③ Inhibit the uptake of glucose by intestinal wall cells...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61K31/155A61P3/10A61P3/06
CPCA61K31/4965A61K9/1635A61K9/1652A61K9/2027A61K9/2059A61K31/155
Inventor 王芬黄清华赵田孙强
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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