Method for constructing chemical prevention research mode of esophagus cancer

A chemoprevention and construction method technology, which is applied in the direction of pharmaceutical formulas, preparations for in vivo experiments, medical preparations containing active ingredients, etc., can solve problems affecting the chemoprevention of esophageal cancer

Inactive Publication Date: 2016-11-16
ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in general, due to the lack of a relatively standard chemoprevention research model and chemoprevention model construction method, there may be some differences in the effect of the same drug when evaluated based on different methods, which affects the chemoprevention of esophageal cancer to a certain extent. development of

Method used

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  • Method for constructing chemical prevention research mode of esophagus cancer
  • Method for constructing chemical prevention research mode of esophagus cancer
  • Method for constructing chemical prevention research mode of esophagus cancer

Examples

Experimental program
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Embodiment

[0037] Taking the rat esophageal carcinogenesis model induced by NMBA and the role of isorhamnol in the chemoprevention of esophageal cancer as an example, the construction method of the esophageal cancer chemoprevention animal model provided by this application is briefly introduced as follows.

[0038] The specific construction steps of the method for constructing an animal model for chemoprevention of esophageal cancer provided in this application are as follows.

[0039] (1) First, conduct a preliminary evaluation of the cytotoxicity of the chemopreventive agent and its inhibitory effect on cell proliferation and transformation, so as to determine the most suitable dosage range of the chemical agent;

[0040] This example is mainly based on the evaluation of the effectiveness of isorhamnol in the chemoprevention of esophageal cancer as an example. Therefore, the cytotoxicity of isorhamnol to SHEE cells, the inhibitory effect of cell proliferation and the inhibitory effect o...

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Abstract

The invention belongs to the technical field of cancer treatment and prevention and relates to a method for constructing a chemical prevention research mode of esophagus cancer. The method comprises the following steps: evaluating medicament dosage, selecting experimental animals, performing chemical induction on esophagus cancer, evaluating chemical agent effects and the like. The design thought of the invention is that in the process of inducing esophageal canceration of rats, a chemical prevention effect of related chemical prevention agents is accurately evaluated by influencing the occurrence rate and diversity of precancerous lesions and evaluating molecular expression conditions of esophageal canceration correlation indexes through enzyme-linked immunosorbent assay. By taking an NMBA induced esophageal canceration mode as an example, the effects of quercetin-3-methylether in chemical prevention of esophagus cancer are specifically evaluated. The results prove that the evaluation method is objective and comprehensive, lays a good foundation for further application of the quercetin-3-methylether in chemical prevention of esophagus cancer and also provides experiences and references for standardization of prevention and treatment of other related cancers.

Description

technical field [0001] This application belongs to the technical field of cancer treatment and prevention, and specifically relates to a patent application for a construction method of a chemoprevention research model for esophageal cancer. Background technique [0002] Esophageal cancer is one of the most common malignant tumors in the world, ranking sixth among the most common tumors that cause cancer death, with a poor prognosis and a five-year survival rate of only 8-12%. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are the two main histological types of esophageal cancer. ESCC is the most common subtype in developing countries, but in the United States and other Western countries esophageal cancer is predominantly EAC. In recent years, although the early screening and early diagnosis techniques of esophageal cancer have been improved, and the standard chemotherapy and radiotherapy have been used clinically for decades, the survival rate...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K31/135
CPCA61K31/135A61K49/008
Inventor 刘康栋董子明江亚南赵四敏赵继敏董子钢常俊标李洪林李恩民别荣海
Owner ZHENGZHOU UNIV
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