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Application of medicines for invigorating qi and promoting blood circulation in the preparation of medicines for bradyarrhythmia

A slow-moving technology that nourishes qi and activates blood, and is used in drug combinations, pharmaceutical formulations, and plant raw materials. quality effect

Active Publication Date: 2020-02-21
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern Western medicine uses aminophylline, isoproterenol, atropine, ephedrine and other drugs and installs a pacemaker, and the clinical effect is remarkable. However, because the above drugs have their own side effects and poor patient compliance, they should not be used for a long time
Pacing therapy is not yet popular due to high technical and equipment requirements and high price

Method used

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  • Application of medicines for invigorating qi and promoting blood circulation in the preparation of medicines for bradyarrhythmia
  • Application of medicines for invigorating qi and promoting blood circulation in the preparation of medicines for bradyarrhythmia
  • Application of medicines for invigorating qi and promoting blood circulation in the preparation of medicines for bradyarrhythmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The medicine tablet that is used for the treatment of bradyarrhythmia is made of the crude drug of following parts by weight:

[0040]

[0041]

[0042] The preparation method of the medicine tablet comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half the amount of astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder, made into granules, dried, compressed into 1000 tablets (small tablets), coated with sugar or f...

Embodiment 2

[0044] The medicinal capsule for the treatment of bradyarrhythmia is made of the bulk drug of following parts by weight:

[0045]

[0046] The preparation method of the drug capsule comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of the astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder, and made into capsules. For the treatment of sinus bradycardia, and / or second-degree atrioventricular block, and / or third-de...

Embodiment 3

[0048] The medicinal granule for the treatment of bradyarrhythmia is made of the bulk drug of following parts by weight:

[0049]

[0050]

[0051]

[0052] The preparation method of the drug granules comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of astragalus in the raw materials, pulverizing them into fine powder, decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder to make granules. For the treatment of sinus bradycardia, and / or second-degree atrioventricular block, and / o...

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Abstract

The invention discloses the application of a drug for replenishing qi and activating blood in the preparation of a drug for bradyarrhythmia. The raw material medicine of the medicine for replenishing qi and promoting blood circulation is composed of: 100-150 parts by weight of astragalus, 80-120 parts by weight of Codonopsis pilosula, 60-100 parts by weight of salvia miltiorrhiza, 60-100 parts by weight of kudzu root, 60-100 parts by weight of epimedium hawthorn 60-100 parts by weight, 40-80 parts by weight of Rehmannia glutinosa, 40-80 parts by weight of Angelica sinensis, 40-80 parts by weight of Coptidis rhizome, 40-80 parts by weight of vinegar corydalis, 40-80 parts by weight of Ganoderma lucidum, 20-30 parts by weight of ginseng, Licorice 20-30 parts by weight. Pharmacodynamic experiments have found that the drug for nourishing qi and activating blood circulation of the present invention has a clear vasodilation effect, and also has obvious scavenging effects on nitrogen free radicals, hydroxyl free radicals and nitroxide free radicals. The medicine of the present invention can improve the calm heart rate, 24-hour total heart rate, the fastest heart rate, the slowest heart rate and the average heart rate of patients with bradyarrhythmia. The application of randomized controlled studies shows that the embodiment of the present invention 1 is a pair of embodiment 1 of the present invention. Bradyarrhythmia has a definite curative effect.

Description

technical field [0001] The invention belongs to the field of application of traditional Chinese medicines, and in particular relates to the application of a drug for invigorating qi and promoting blood circulation in the preparation of a drug for bradyarrhythmia. Background technique [0002] Arrhythmia (arrhythmia) is due to abnormal sinoatrial node excitation or excitation outside the sinoatrial node, the conduction of the excitation is slow, blocked, or conducted through abnormal channels, that is, the origin of cardiac activity and / or conduction disorders lead to the frequency of cardiac beating And (or) abnormal rhythm. The types of arrhythmia include sinus tachycardia, sinus bradycardia, sinus arrest, sinoatrial block, sick sinus syndrome, etc. Different types of arrhythmia have different treatment options such as medication . [0003] Bradyarrhythmia is one of the common syndromes in cardiovascular system diseases, mainly including sinus bradycardia, atrioventricula...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P9/06
CPCA61K9/2004A61K36/074A61K36/232A61K36/258A61K36/296A61K36/344A61K36/481A61K36/484A61K36/488A61K36/537A61K36/66A61K36/718A61K36/734A61K36/804A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 孟晓萍姜作玲张斯斯洪毅王辉
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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