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A kind of detection method of dogwood granules

A detection method and the technology of Cornus officinalis, applied in the field of Cornus officinalis granules and traditional Chinese medicine preparations containing the cornus officinalis granules, can solve the problems of inability to meet real-time analysis of multi-variety, multi-batch samples, physical injury of inspectors, information feedback lag, etc. problem, to achieve the effect of easy control of process parameters, high accuracy and stable process parameters

Active Publication Date: 2017-09-26
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture in cornus granules requires several hours with reference to the pharmacopoeia, and the operation is more complicated.
The main chemical component of cornus granules is loganin. As a quality control index, the traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a large amount of reagents, and pollutes the environment. Physical damage to inspectors, delayed information feedback, unable to meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • A kind of detection method of dogwood granules
  • A kind of detection method of dogwood granules
  • A kind of detection method of dogwood granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of cornus granules: take decoction pieces of cornus, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, and concentrate the filtrate to a relative density of 1.08 (80°C) The clear paste is filtered with a 350-mesh sieve while it is hot; it is spray-dried under the conditions of an inlet air temperature of 175°C, a material pump speed of 500 rpm, an outlet air temperature of 90°C, and an air delivery temperature of 40°C to obtain a spray-dried powder; Dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 45HZ, oil cylinder pressure 20bar, to obtain cornus granules with a particle size of 40 mesh.

Embodiment 2

[0034] The preparation of the traditional Chinese medicine preparation containing cornus granules: take the decoction pieces of cornus, add water and decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; the medicinal liquids are combined, and the filtrate is concentrated to a relative density of 1.08 ( 80 DEG C) clear paste, filtered with 350 mesh sieve while hot; Carry out spray drying under the conditions of 175 DEG C of inlet air temperature, 500 rpm of material pump speed, 90 DEG C of outlet air temperature, and 40 DEG C of air supply temperature to obtain Spray dry powder; dry granulate under the conditions of punching plate aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 45HZ, oil cylinder pressure 20bar, to obtain cornus granules with a particle size of 40 meshes; mix 200g cornus granules with 85g malt paste Finely mix, add appropriate amount of magnesium stearate, mix evenly, and press into 1000 tablet...

Embodiment 3

[0036] A method for rapidly detecting the moisture content of cornus granules based on near-infrared spectroscopy, specifically comprising the steps of:

[0037] a. Take cornus granule samples, a total of 83 batches, about 3g each, grind into fine powder, put into a stoppered glass sample bottle, place on a near-infrared scanner to scan, collect spectra, scanning conditions: scan Range 4000-12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum figure of 83 batches of cornus granules shown;

[0038] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content is measured by the drying method. About 2 g of cornus granules that are ground into fine powder are spread in a flat weighing bottle that is dried to co...

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Abstract

The invention discloses dogwood pulp granules and a traditional Chinese medicinal preparation thereof. The preparation method of the dogwood pulp granules comprises following steps: boiling medicinal dogwood slices for 2-3 times with water, namely, adding 5-10 times of water each time, and boiling for 1-2 hours each time; combining decoctions, concentrating the filtrate till clear paste of which the relative density is 1.02-1.12 is prepared, and filtering by using a sieve of 250-350 meshes while the clear paste is hot; performing spray drying on the clear paste so as to obtain spray-dried powder; granulating the spray-dried powder, thereby obtaining the dogwood pulp granules of which the granularity is 16-40 meshes. The dogwood pulp granules disclosed by the invention are simple in preparation process, process parameters are easy to control, and a scientific, rapid and operable detection method is used.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a cornus granule and a traditional Chinese medicine preparation containing the cornus granule. Background technique [0002] Cornus is the dry pseudobulb of the orchid plant Rhododendron orchid Cremastra appendiculata (D.Don) Makino, Pleione bulbocodioides (Franch.) Rolfe or Yunnan single garlic orchid Pleione yunnanensis Rolfe, sweet, slightly pungent, cool, with heat-clearing properties Detoxification, the effect of resolving phlegm and resolving stagnation. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359A61K36/40A61K9/16G01N21/3563A61P29/00A61P11/10A61P39/02
CPCA61K9/1605A61K36/40A61K2236/331A61K2236/39A61K2236/51G01N21/3563G01N21/359
Inventor 程学仁朱德全赵径华刘丽萍霍文杰陈向东谭登平
Owner GUANGDONG YIFANG PHARMA
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