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Wuzi yanzong pills and preparation method thereof

A technique for Wuzi Yanzong pill and pill making, which is applied in the field of Wuzi Yanzong pill and its preparation, can solve the problems of inconvenient carrying, transportation and storage, need to improve drug efficacy, large drug dispersion, etc., so as to improve the utilization of medicinal materials and enhance the content transfer. rate, the effect of stable drug efficacy

Inactive Publication Date: 2016-10-12
TAIJI GROUP SICHUAN MIANYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the production process of Wuzi Yanzong Pills, the biggest advantage of Wuzi Yanzong Oral Liquid is that the active ingredients are extracted, and the drug effect is better than the existing pills. However, in addition to its fast absorption, the oral liquid also has certain defects. It is a liquid preparation with a large degree of drug dispersion. Affected by the dispersion medium, it is easy to cause chemical degradation of the drug, reducing or even invalidating the drug effect, and the drug effect is unstable. Especially when stored at a high temperature, the shelf life is short. Larger, inconvenient to carry, transport and store, and prone to mildew; third, there is still a large room for improvement in terms of efficacy
[0007] In order to solve the problems referred to above, the applicant of the present invention has developed the concentrated pill of Wuzi Yanzong pill, and its method of making is: Fructus Lycii 1500g, Fructus Cuscuta (fried) 1500g, Raspberry 750g, Fructus Schisandra (steamed with vinegar) 187.5g, Fructus Plantaginis ( Stir-fried with salt) 375g, the above-mentioned five-flavor medicinal materials, add 6 times the amount of 70% ethanol to reflux and extract twice, each time for 2 hours, combine the extracts, filter, and recycle the ethanol from the filtrate to tasteless, and concentrate to a relative density of 1.10 (50 ° C ), centrifugal filtration, the filtrate continued to concentrate to a relative density of 1.30-1.32 (50°C), added 400-500g of microcrystalline cellulose, mixed to make pellets, and dried to obtain 1000g of dry pellets. 1-2g, twice a day; however, the concentrated pills are simply refluxed with 70% ethanol, and then simply concentrated, and the ineffective ingredients and heavy metals left in the medicinal materials still exist in the pills, while some active ingredients And because of the problems of the extraction solvent and method, it was left in the dregs of the medicine and did not enter the extraction solution, so its efficacy still needs to be improved, and the risk of side effects of long-term use is also relatively high

Method used

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  • Wuzi yanzong pills and preparation method thereof
  • Wuzi yanzong pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of Wuzi Yanzong pill, its preparation method comprises the following steps:

[0031] a. Weigh the raw materials, and take the raw materials in the following parts by weight:

[0032] 520g medlar, 520g dodder (fried), 260g raspberry, 65g vinegar Schisandra, 130g salted psyllium;

[0033] b. Pretreatment: crush the five medicinal materials described in step a into a 50-mesh coarse powder;

[0034] c. Extraction and concentration: the medical material processed in step b is refluxed 4 times with ethanol with 12 times the quality of the medicinal material, each time refluxing 2h, 2h, 1h and 0.5h respectively, and the used ethanol concentration is 65% (volume ratio). The secondary reflux temperature is 35°C, 45°C, 50°C and 65°C respectively, then filter press, combine the press filtrate, pretreat with a diaphragm filter press, remove impurities such as sediment, and obtain a filtrate, which is passed through a hollow fiber membrane ultra Filter out impurities (remov...

Embodiment 2

[0037]Embodiment 2: effect experiment

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Abstract

The invention discloses Wuzi yanzong pills and a preparation method thereof and belongs to the field of traditional Chinese medicine preparations. The preparation method includes: weighing raw materials; pretreating and smashing; adopting a GT circulating extraction method for extraction; adopting a film concentration method for concentration; depressurizing for secondary concentration; pilling. Type and content of active ingredients are remarkably increased, content of inactive and harmful ingredients is remarkably increased, and the pills are better in treatment effect, less in side effect and safer for long-time administration; administration amount is further reduced, so that the pills are more convenient to carry and stable and reliable in quality after being stored for a long time.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Wuzi Yanzong pill and a preparation method thereof. Background technique [0002] In recent years, my country's aging trend has been severe. With the introduction of the second-child policy, "birth" has become a hot topic. However, infertility has become a major problem affecting fertility around the world. Infertility is divided into female infertility and male infertility. The main reason for male infertility is abnormal semen, low sperm count, and poor sperm quality. , low motility, and deformed sperm; followed by sexual dysfunction and reproductive organ diseases. [0003] Wuzi Yanzong Fang has been known as the "No. 1 Seed Formula" since ancient times. It uses selected plant seeds and medicinal materials, which are natural and environmentally friendly, and can significantly improve the quality of sperm. It is clinically used to treat impotence and...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/20A61P15/08A61P15/00
CPCA61K36/815A61K9/2059A61K36/39A61K36/43A61K36/57A61K36/68A61K36/73A61K36/79A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 胡敏吴用彦贾清树
Owner TAIJI GROUP SICHUAN MIANYANG PHARMA
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