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Application of marihuana extract in preparation of gout treating medicine

The technology of extract and cannabis is applied to the application field of cannabis extract in the preparation of medicine for treating gout, and can solve the problems of inability to use for a long time, large side effects, poor curative effect, etc., and achieves inhibition of toe swelling, small toxic and side effects, and strong anti-inflammatory properties. effect of gout

Inactive Publication Date: 2016-10-12
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor curative effect and large side effects have become the bottleneck of its clinical application, and it cannot be used for a long time
There are also some Chinese patent medicine preparations commonly used in the market to treat tongfeng, but the efficacy is relatively low.

Method used

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  • Application of marihuana extract in preparation of gout treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and crush, then extract with CO2, redissolve in methanol after removing impurities, and elute the solution with hexane after separation by chromatography column, collect and elute liquid, concentrated under reduced pressure, vacuum dried, and pulverized to obtain tetrahydrocannabinol. Take cannabis flowers and leaves, after impurity removal, drying, and crushing, CO2 super-extraction, ethanol redissolution after impurity removal, chromatographic separation of the solution and pentane elution, collect the eluate, concentrate under reduced pressure, vacuum Dried and crushed to obtain cannabidiol.

[0043] Tetrahydrocannabinol and cannabidiol are mixed according to the weight ratio of 4:1 to 1:4 to prepare the required cannabis extract.

[0044] Get 100 grams of hemp extract (through 80 mesh sieve), add 60 grams of microcrystalline cellulose, pass through 80 mesh sieve three times, mix we...

Embodiment 2

[0046] Take cannabis flowers and leaves, remove impurities, dry and crush, then extract with CO2, dissolve in methanol after removing impurities, and elute the solution with hexane after separation by chromatography column, collect the eluate, concentrate under reduced pressure, Vacuum-dried and pulverized to obtain tetrahydrocannabinol. Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and pulverize, then extract with CO2, and dissolve in ethanol after removing impurities. The solution is separated by chromatography and eluted with pentane, and the eluate is collected. Concentrate under reduced pressure, dry in vacuum, and pulverize to obtain cannabidiol.

[0047] Tetrahydrocannabinol and cannabidiol are mixed according to the weight ratio of 4:1 to 1:4 to prepare the required cannabis extract.

[0048] The hemp extract powder is taken, 5-20% of dry starch and 1-5% of magnesium stearate are added, mixed, granulated, dried and compressed to ...

Embodiment 3

[0050] Repeat Example 2, with the following differences: get the hemp extract powder, add sucrose water and a conventional amount of preservatives, stabilizers and other auxiliary materials. Filter, sterilize, and divide into 10mL bottles to make oral liquid.

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Abstract

The invention discloses application of a marihuana extract in preparation of gout treating medicine. Inventors find that tetrahydrocannabinol and cannabidiol have the quite strong gout resisting effect after being mixed according to the specific ratio for the first time, the hyperuricemia mouse serum uric acid level can be remarkably lowered, no obvious influence is produced to the normal mouse serum uric acid level, toe swelling induced by sodium urate can be remarkably restrained, activity is similar to that of allopurinol, and the toxic and side effect is small. The marihuana extract has the obvious gout treating and preventing effect. The invention further provides a gout treating medicinal preparation of the marihuana extract and a corresponding dosage form thereof. Various kinds of medicine with different dosage forms can be used clinically through a conventional preparation method, and use is convenient.

Description

technical field [0001] The invention relates to the new application of cannabis in medicine, in particular to the application of a cannabis extract in the preparation of medicine for treating gout. Background technique [0002] Gout is a kind of disease caused by the disorder of purine metabolism in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, which can cause hyperuricemia. When the blood uric...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/05A61P19/06
CPCA61K31/352A61K31/05A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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