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Empty capsule and soft capsule based on modified starch

A technology of hollow capsules and soft capsules, which is applied in the fields of capsule transportation, medical preparations of non-active ingredients, and pharmaceutical formulas. Less cross-linking phenomenon, low cost effect

Inactive Publication Date: 2016-10-12
安顺济世科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many domestic manufacturers have also conducted research on the feasibility of starch capsules and soft capsules. However, because starch molecules are prone to form strong hydrogen bonds, the starch film lacks toughness and is fragile, and it is difficult to produce high-strength, filling-resistant capsules and soft capsules. soft capsule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Blue hollow capsules were prepared from 70 parts of potato starch, 9 parts of gum arabic, 5 parts of xylitol, 2 parts of calcium chloride, 40 parts of hydroxypropyl cellulose, 100 parts of deionized water and 1 part of brilliant blue. The prepared hollow capsules were subjected to disintegration time limit test and friability test. According to the second appendix of "Chinese Pharmacopoeia" 2012 edition, the disintegration time limit inspection was carried out. Water was used as the medium at a temperature of 37°C, and a baffle was added for the test. The judgment standard was that all capsules were completely disintegrated within 20 minutes. According to the second appendix of "Chinese Pharmacopoeia" 2012 edition, check the friability. Take 50 empty capsules, put them in a watch glass, put them in a desiccator filled with a saturated solution of magnesium nitrate, take them out at a constant temperature of 25°C±1°C for 24 hours, and separate them immediately. Put the c...

Embodiment 2

[0026] 60 parts of corn starch, 8 parts of pectin, 5 parts of glycerin, 1 part of sodium chloride, 35 parts of hydroxypropyl cellulose, 90 parts of deionized water and 1 part of titanium dioxide are used as raw materials to prepare white hollow capsules. The prepared hollow capsules were subjected to disintegration time limit test and friability test. According to the second appendix of "Chinese Pharmacopoeia" 2012 edition, the disintegration time limit inspection was carried out. Water was used as the medium at a temperature of 37°C, and a baffle was added for the test. The judgment standard was that all capsules were completely disintegrated within 20 minutes. According to the second appendix of "Chinese Pharmacopoeia" 2012 edition, check the friability. Take 50 empty capsules, put them in a watch glass, put them in a desiccator filled with a saturated solution of magnesium nitrate, take them out at a constant temperature of 25°C±1°C for 24 hours, and separate them immediatel...

Embodiment 3

[0028] 80 parts of tapioca starch, 10 parts of carrageenan, 5 parts of glycerin, 2 parts of sodium bromide, 45 parts of hydroxypropyl cellulose and 120 parts of deionized water were used as raw materials to prepare transparent hollow capsules. The prepared hollow capsules were subjected to disintegration time limit test and friability test. According to the second appendix of "Chinese Pharmacopoeia" 2012 edition, the disintegration time limit inspection was carried out. Water was used as the medium at a temperature of 37°C, and a baffle was added for the test. The judgment standard was that all capsules were completely disintegrated within 20 minutes. According to the second appendix of "Chinese Pharmacopoeia" 2012 edition, check the friability. Take 50 empty capsules, put them in a watch glass, put them in a desiccator filled with a saturated solution of magnesium nitrate, take them out at a constant temperature of 25°C±1°C for 24 hours, and separate them immediately. Put the...

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Abstract

The invention discloses an empty capsule and a soft capsule based on modified starch. The empty capsule is prepared from the following raw materials: 40 to 90 parts of the edible modified starch, 3 to 30 parts of gelatinizer, 2 to 20 parts of plasticizer, 2 to 20 parts of plant fiber, 10 to 50 parts of deionized water, 1 to 6 parts of colorant and opacifier, and the empty capsule is prepared by the following procedures of mixing, glue dissolving, degassing, dipping, drying, shell pulling and cutting; the soft capsule is prepared from the following raw materials: 30 to 60 parts of edible modified starch, 8 to 40 parts of gelatinizer, 6 to 20 parts of plasticizer, 6 to 20 parts of plant fiber, 20 to 60 parts of deionized water, 1 to 6 parts of colorant and opacifier, and the soft capsule is prepared by the following procedures of mixing, glue dissolving, degassing, dipping, drying, shell pulling and cutting. According to the empty capsule and the soft capsule, a series of problems of long disintegration time, fragility, poor water retention and the like of an existing starch capsule and soft capsule are solved, and gelatin is replaced by starch, so that the empty capsule and the soft capsule have the advantages of low cost, stable chemical properties, difficulty in growing of microorganism, difficulty in getting fragile, difficulty in crosslinking and the like and are suitable for long-term storage.

Description

technical field [0001] The invention relates to the technical field of food and pharmaceutical industrial production, in particular to the technical field of non-animal source hollow capsules and soft capsule formulations. Background technique [0002] Empty capsules and soft capsules on the market are mainly made of animal-derived gelatin. Gelatin hollow capsules and soft capsules are made of gelatin with auxiliary materials. The capsules can effectively cover up the unpleasant taste and smell of the contents, and truly realize that the good medicine is no longer bitter. Capsules and soft capsules can contain various drug powders, liquids, semi-solids and tablets. Capsules and soft capsules have good bioavailability because capsules and soft capsules can dissolve quickly, reliably and safely to release the encapsulated drugs, Therefore, gelatin capsules and soft capsules were quickly promoted and applied in the production of various solid preparations. Since its developme...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36
CPCA61K9/4816
Inventor 杨元勇周顺刘光静杨琼敏席小逆
Owner 安顺济世科技有限公司
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