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Bone tissue engineering scaffold with multi-scale controllable micropore structure and preparation method thereof

A technology of tissue engineering scaffold and bone tissue engineering, which is applied in the field of biomedical materials, can solve the problems such as the inability to realize nanoscale, achieve adjustable mechanical properties, meet biomechanical requirements, and meet the effect of protein adsorption

Active Publication Date: 2016-09-21
成都百年贝雅医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although 3D printing technology can theoretically realize the preparation of any hole shape and structure, in fact, due to the limitation of printing accuracy, such as the diameter of the printing nozzle, the printing material thread, particle size, etc., it is often impossible to achieve nanoscale and microscopic size less than 10 μm. hole forming

Method used

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  • Bone tissue engineering scaffold with multi-scale controllable micropore structure and preparation method thereof
  • Bone tissue engineering scaffold with multi-scale controllable micropore structure and preparation method thereof
  • Bone tissue engineering scaffold with multi-scale controllable micropore structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The biomimetic multi-scale controllable microporous structure bone tissue engineering scaffold was prepared by using the thermoplastic medical polymer material PLA as the raw material. Its production specific steps are as follows:

[0044] 1) Choose Φ1.75mm medical-grade PLA material wire, and form a micron-scale three-dimensional porous tissue engineering scaffold through FDM three-dimensional printing. In the specific printing process, choose a single nozzle with a diameter of Φ0.2mm for printing. The speed is 150mm / s, the design size of the macroscopic holes in the cross-section is 200×200μm orthogonal macropores, and the layer thickness in the vertical direction is 200μm. The final dimension of the formed scaffold is Φ8×6mm, the dimension of the macroscopic pores of the scaffold is about 200×200×200μm, the porosity is about 50%, and the macropores are three-dimensionally interpenetrating and connected, which is isotropic.

[0045] 2) The three-dimensional macroporo...

Embodiment 2

[0047] Other conditions and processes are the same as those in Example 1, except that a different three-dimensional printing process is used in Step 1. In its specific printing process, a single nozzle with a diameter of Φ0.4mm is selected for printing, the temperature of the nozzle is 200°C, the printing speed is 150mm / s, and the macroscopic holes in the section are designed to be orthogonal large holes with a size of 400×400μm. The layer thickness was 400 μm. The final dimension of the formed scaffold is Φ8×6mm, the dimension of the macroscopic macropores of the scaffold is about 400×400×400μm, the porosity is about 52%, and the macropores are three-dimensionally interpenetrating and connected, which is isotropic. After the supercritical gas foaming process in Step 2 of Example 1, the macroscopic macropore size of the finally formed biomimetic multi-scale microporous structure scaffold is about 420×420×420 μm, and the secondary micro-nano scale micropores formed in the print...

Embodiment 3

[0049] Other conditions and processes are the same as those in Example 1, except that a different three-dimensional printing process is used in Step 1. In the specific printing process, a single nozzle with a diameter of Φ0.4mm is selected for printing, the temperature of the nozzle is 200°C, the printing speed is 150mm / s, and the macroscopic holes in the section are designed to be orthogonal large holes with a size of 600×600μm. The layer thickness was 400 μm. The final dimension of the formed scaffold is Φ8×6mm, the dimension of the macroscopic macropores of the scaffold is about 600×600×400μm, the porosity is about 66%, and the macropores are three-dimensionally interpenetrating and connected, which is isotropic. After the supercritical gas foaming process in Step 2 of Example 1, the macroscopic and macropore size of the finally formed biomimetic multi-scale microporous structure scaffold is about 620×620×420 μm, and the secondary micro-nano scale micropores formed in the p...

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Abstract

The invention provides a bionic bone tissue engineering scaffold material and preparation method thereof, and the scaffold material has multi-level micropore structure similar to the natural bone tissue. The scaffold has multi-level bionic bone three-dimensional pore structure which can be adjusted in the range from 500 nm to 1000 mum. The preparation method of the bone tissue engineering scaffold with multi-scale controllable micropore structure includes performing three-dimensional printing with medical polymer material by using a rapid proto-typing technology, customizing the primary-level micrometer scale three-dimensional pore structure and the shape of the scaffold, and preparing the second-level micrometer and nanometer scale micropore inside of the scaffold by using supercritical gas foaming. The prepared bone tissue engineering scaffold with multi-scale micropore structure can provide the three-dimensional supporting needed by the bone tissue regeneration, can meet the requirements of protein adsorption, nutriment / metabolite transportation, cell migration, and tissue growing in different scales, and has wide application prospect in orthopedic clinic.

Description

technical field [0001] The invention relates to a bone tissue engineering scaffold material with a multi-scale controllable microporous structure prepared by combining three-dimensional printing rapid prototyping and supercritical fluid foaming technology and a preparation method thereof, belonging to the field of biomedical materials. technical background [0002] Natural bone tissue is a tissue with a complex hierarchical pore structure. An ideal bone tissue engineering scaffold should try to design a microporous structure similar to the anatomy of natural bone tissue, and at the same time have good biocompatibility and easy bonding to surrounding bone tissue. In order to meet the needs of new bone tissue ingrowth, bone tissue engineering scaffolds must be designed with an interpenetrating three-dimensional porous structure. The three-dimensional pore structure can provide the necessary living space for the adhesion, migration and proliferation of bone cells, and at the s...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/18A61L27/54C08J9/12
CPCA61L27/18A61L27/54A61L27/56A61L2300/412A61L2430/02C08J9/122C08J2203/06C08J2203/08C08J2367/04C08L67/04C08L71/02
Inventor 周长春樊渝江王科锋朱向东裴玄殷国富张兴栋
Owner 成都百年贝雅医疗科技有限公司
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