Pharmaceutical composition capable of improving safety of compound manglietia injection
A technology of composition and injection, which is applied in the field of medicine, can solve the problems of solution pH drop, polysorbate 80 is prone to rancidity, and accelerates the pH value of liquid medicine, etc., and achieves high dosage, improved safety, and good safety effects
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Embodiment 1
[0016]
[0017] Preparation method: Add water to decoct magnolia and solanum nigrum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make it contain ethanol The amount is 65%, stand overnight, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate under reduced pressure to The relative density is about 1.15 (80°C), and the liquid medicine is for later use; decoct plantains with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure to a relat...
Embodiment 2
[0019]
[0020]
[0021] Preparation method: Add water to decoct magnolia and solanum nigrum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make it contain ethanol The amount is 65%, stand overnight, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate under reduced pressure to The relative density is about 1.15 (80°C), and the liquid medicine is for later use; decoct plantains with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressur...
Embodiment 3
[0023]
[0024]
[0025]Preparation method: Add water to decoct magnolia and solanum nigrum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make it contain ethanol The amount is 65%, stand overnight, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate under reduced pressure to The relative density is about 1.15 (80°C), and the liquid medicine is for later use; decoct plantains with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure...
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Abstract
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