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Pharmaceutical composition capable of improving safety of compound manglietia injection

A technology of composition and injection, which is applied in the field of medicine, can solve the problems of solution pH drop, polysorbate 80 is prone to rancidity, and accelerates the pH value of liquid medicine, etc., and achieves high dosage, improved safety, and good safety effects

Inactive Publication Date: 2016-09-21
CHENGDU YISHENGKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Pharmaceutical composition capable of improving safety of compound manglietia injection
  • Pharmaceutical composition capable of improving safety of compound manglietia injection
  • Pharmaceutical composition capable of improving safety of compound manglietia injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]

[0017] Preparation method: Add water to decoct magnolia and solanum nigrum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make it contain ethanol The amount is 65%, stand overnight, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate under reduced pressure to The relative density is about 1.15 (80°C), and the liquid medicine is for later use; decoct plantains with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure to a relat...

Embodiment 2

[0019]

[0020]

[0021] Preparation method: Add water to decoct magnolia and solanum nigrum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make it contain ethanol The amount is 65%, stand overnight, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate under reduced pressure to The relative density is about 1.15 (80°C), and the liquid medicine is for later use; decoct plantains with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressur...

Embodiment 3

[0023]

[0024]

[0025]Preparation method: Add water to decoct magnolia and solanum nigrum twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make it contain ethanol The amount is 65%, stand overnight, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate under reduced pressure to The relative density is about 1.15 (80°C), and the liquid medicine is for later use; decoct plantains with water twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C), let it cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pressure...

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Abstract

The invention discloses a pharmaceutical composition capable of improving safety of a compound manglietia injection. The pharmaceutical composition for injection is characterized by being mainly prepared from a manglietia extract, an extract of black nightshade herb, a banana extract and polyethylene glycol dodecahydroxyl stearate, wherein each 100ml of the solution (the pharmaceutical composition) consists of the manglietia extract of 10-20g of a manglietia medicinal material, the black nightshade herb extract of 10-20g of a black nightshade herb medicinal material and the banana extract of 1-2g of a banana medicinal material, and the dosage ratio of the manglietia medicinal material to the black nightshade herb medicinal material to the banana medicinal material is 10 to 10 to 1. According to the pharmaceutical composition disclosed by the invention, a cosolvent, namely polysorbate 80, which has safety hidden dangers and has influence on product quality in the compound manglietia injection is replaced by a cosolvent which is better in safety and is more remarkable in dissolve-assisting effect with a lower dosage, so that the probability and risks of adverse reactions of the medicine (the pharmaceutical composition) are reduced, and the safety of clinical administration is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for improving the safety of compound magnolia injection. Background technique [0002] The standards of Compound Mulian Injection are recorded in the Drug Standards issued by the Ministry of Health (preparation of traditional Chinese medicines). It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Mulian Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditional Chinese medicine injections have become more and more serious, which has affected the development ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/19A61K9/08A61K47/34A61P15/00A61P29/00A61P17/02
CPCA61K36/57A61K9/0019A61K9/08A61K9/19A61K36/81A61K36/88A61K47/14A61K47/26A61K2300/00
Inventor 张蛟
Owner CHENGDU YISHENGKE BIOTECH
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