Micro-fluidic chip for viscosity testing, and preparation method

Abstract

The invention discloses a micro-fluidic chip for viscosity testing, and a preparation method. The chip comprises five structures: a PDMS substrate with a miniature groove, detection electrodes, a PVDF nanofiber film, a PDMS film and a PDMS cover plate with a miniature channel. The preparation method comprises the steps: firstly making the substrate with the miniature groove and the PDMS miniature flow channel cover plate through the photoetching of SU8 photoresist and the demoulding technology; secondly making a pair of detection electrodes at two sides of the miniature groove of the PDMS substrate through employing a mask magnetron sputtering method; thirdly transferring the PVDF film, made through employing an electrostatic spinning method, to the electrodes; finally carrying out the bonding of the substrate and the cover plate, and forming a complete micro-fluidic chip. The micro-fluidic chip is stable in structure, facilitates the integration, is small in number of demands for samples, has no requirements for class, is short in testing time, does not need power, and facilitates the extension of a manufactured micro-fluidic chip viscometer to miniaturization even a hand-held type.

Description

technical field [0001] The invention relates to a microfluidic chip for viscosity testing and a manufacturing method thereof, in particular to a manufacturing method of a self-powered viscosity testing microfluidic chip based on piezoelectric power generation effect, which belongs to organic nano functional materials and microfluidic technology field. Background technique [0002] Viscosity is a very important physical parameter of fluid-based dynamic behavior. In many practical applications, the measurement of fluid viscosity is an essential work. For example, the measurement of plasma viscosity in the process of coagulation testing is a very important task. Similarly, in drugs based on protein antibodies and some macromolecular solutions, viscosity is also a very important indicator of such drugs. In addition, some cardiovascular diseases with a high incidence rate in today's society are often caused by changes in blood viscosity due to the high concentration of some mac...

AI Technical Summary

Problems solved by technology

However, the microfluidic chip with this four-layer structure cannot be used for liquid testing with a certain viscosity. The main reasons are: (1) In terms of materials, "Microfluidic chip with self-power supply function and its manufacturing method" (201510304240.5) KNN is used as the piezoelectric material. The rigidity and brittleness of the material are relatively high, and the hard substrate under the material will also affect the deformation of the material. Therefore, the small mechanical energy of the fluid has limited deformation of the material, and the output voltage is small. (only mV level), it is difficult to test the viscosity

(2) Structurally, the piezoelectric material in "Microfluidic Chip with Self-Power Supply Function and Its Fabrication Method" (201510304240.5) is directly exposed in the microchannel, and the fluid in the microchannel will directly contact the piezoelectric material. When there are charged particles, it will have a shielding effect on the piezoelectric material, which seriously affects the improvement of the voltage output amplitude of the piezoelectric material, and this is also not conducive to the stability and long-term application of the device.

In view of this, the microfluidic chip disclosed in "Microfluidic chip with self-power supply function and its manufacturing method" (201510304240.5) cannot be applied to viscosity testing

[0005] In summary, the idea and practice of a microfluidic chip with self-powered function and its manufacturing method that can be used for viscosity testing has not been found in published literature or patented technologies

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