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Orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and preparation method thereof

A technology of freeze-dried powder, Yinzhihuang, applied in the field of oral freeze-dried powder of Yinzhihuang and its preparation, can solve the problem of affecting drug bioavailability and drug effect, increasing the uncertainty of children's drug safety, destroying the structure of drug dosage forms, etc. The problem is to overcome the heat loss of pharmaceutical ingredients, be conducive to long-term storage, and reduce allergies.

Inactive Publication Date: 2016-08-31
HEFEI HUAFANG PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lack of children's specifications leads to the need to divide the dosage into 2, 4 or more parts on average in clinical application, which not only makes it difficult to ensure the accuracy of the dosage, but also destroys the dosage form structure of the drug, which affects the efficacy of the drug to varying degrees. Bioavailability and drug effects lead to reduced drug efficacy, increased side effects and waste of drugs, which greatly increases the uncertainty of children's drug safety

Method used

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  • Orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and preparation method thereof
  • Orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and preparation method thereof
  • Orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] In the specific implementation of the present invention, Yinzhihuang oral freeze-dried powder is composed of capillary extract, gardenia extract, scutellaria baicalensis extract and honeysuckle extract, and the component ratio is capillary chen extract:gardenia extract:scutellaria baicalensis Extract (calculated as baicalin): honeysuckle extract=0.8~2.0:0.5~1.0:2~10:0.2~2.0. The preferred component ratio of each component is capillary extract: gardenia extract: scutellaria baicalensis extract (calculated as baicalin): honeysuckle extract=1.5:0.8:5:1. Based on the preparation of 1000 pieces.

[0022] prescription:

[0023]

[0024]Dissolve capillary extract, gardenia extract, and honeysuckle extract with 15% prescription water, adjust the pH value to 6.5 with 10% sodium hydroxide solution, and filter for later use; Paste, add 15% prescription water, adjust the pH value to 6.5-7.0 with 10% sodium hydroxide solution, filter, combine the filtrate with the filtrate obta...

Embodiment 2

[0026] Yinzhihuang oral freeze-dried powder is prepared in 1000 vials.

[0027] prescription:

[0028]

[0029]

[0030] Dissolve capillary extract, gardenia extract, and honeysuckle extract with 15% prescription water, adjust the pH value to 6.5 with 10% sodium hydroxide solution, and filter for later use; Paste, add 15% prescription water, adjust the pH value to 6.5-7.0 with 10% sodium hydroxide solution, filter, combine the filtrate with the filtrate obtained in ①, stir well, refrigerate for 24 hours, adjust the pH value to neutral, add water Adjust the total amount to the specified amount, stir well, let stand, filter, pot, and send it to a vacuum freeze-drying box. The pre-freezing temperature is 0°C, the pre-freezing time is 1 hour, and the cooling rate is 5°C / min. -40°C, keep for 3 hours, then sublimate to -15°C, sublimation temperature rate is 5°C / hour, keep for 8 hours, at this time the vacuum degree is 0.3mbar, after sublimation, analyze and dry at 0°C, keep f...

Embodiment 3

[0032] Yinzhihuang oral freeze-dried powder is prepared in 1000 vials.

[0033] prescription:

[0034]

[0035] Dissolve capillary extract, gardenia extract, and honeysuckle extract with 15% prescription water, adjust the pH value to 6.5 with 10% sodium hydroxide solution, and filter for later use; Paste, add 15% prescription water, adjust the pH value to 6.5-7.0 with 10% sodium hydroxide solution, filter, combine the filtrate with the filtrate obtained in ①, stir well, refrigerate for 24 hours, adjust the pH value to neutral, add water Adjust the total amount to the specified amount, stir well, let it stand, filter, pot, and send it to a vacuum freeze-drying oven. To -50°C, keep for 2 hours, then sublimate to -5°C, the sublimation temperature speed is 5°C / hour, keep for 8 hours, at this time the vacuum degree is 0.2mbar, after sublimation, analyze and dry at 0°C, keep for 2 hours , and then raised the temperature to 35° C. at a rate of 35° C. / hour, and kept it for 2 hour...

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Abstract

The invention discloses orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and a preparation method thereof, and belongs to the field of traditional Chinese medicine preparations. The lyophilized powder is prepared from natural active ingredients of four traditional Chinese medicinal materials, namely capillary artemisia extract, cape jasmine extract, lonicera japonica extract and scutellaria baicalensis extract. The lyophilized powder is prepared by adopting a vacuum lyophilization process, is simple in composition, reasonable in formula, accurate in dosage, free of an auxiliary and the like, can be used for furthest maintaining the natural active ingredients of the medicinal materials, and is convenient to carry and store. Compared with current commercial products, the lyophilized powder has the advantages of remarkable stability and treatment, and is suitable for children patients.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a Yinzhihuang oral freeze-dried powder and a preparation method thereof. Background technique [0002] Jaundice is a common symptom and sign, and its occurrence is caused by the increase of serum bilirubin concentration due to bilirubin metabolism disorder. Clinically, the sclera, mucous membranes, skin and other tissues are stained yellow. [0003] Neonatal jaundice is a common clinical symptom of newborns. About 60% of normal full-term infants and 80% of premature infants may have different degrees of jaundice. Severe cases may develop into kernicterus, causing acute nervous system damage and leading to neonatal jaundice. Neonatal death or sequelae such as mental retardation and movement disorders, pathological jaundice increases the mortality rate of newborns. [0004] Yinzhihuang is a traditional pure Chinese medicine preparation for reducing jaund...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/19A61P1/16
CPCA61K36/282A61K9/0053A61K9/19A61K36/355A61K36/539A61K36/744A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 陈开拓何勇杨贤龙
Owner HEFEI HUAFANG PHARMA SCI & TECH
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