Blood plasma virus inactivation device and method

A virus inactivation and plasma technology, applied in blood transfusion devices, suction devices, etc., can solve the problems of personal risk, high cost, methylene blue residue, etc., to overcome plasma virus inactivation, improve blood transfusion safety, and avoid safety. effect of risk

Inactive Publication Date: 2016-08-24
SICHUAN NIGALE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. It can only inactivate lipid-enveloped viruses, such as HBV, HCV, HIV, etc., and is not sensitive to some non-lipid-enveloped viruses, such as HAV, B19 and other viruses
[0006] 2. The inactivation effect on intracellular virus is not ideal
[0007] 3. Photochemical damage to the cell membrane
[0008] 4. There will always be residues of methylene blue, which may cause potential risks to people
[0009] 5. Due to the adsorption of methylene blue, blood collection and transfusion products must have a filter in structure, and the cost is relatively high

Method used

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  • Blood plasma virus inactivation device and method
  • Blood plasma virus inactivation device and method
  • Blood plasma virus inactivation device and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0030] Such as figure 1 The shown plasma virus inactivation device mainly includes a dropping funnel 6, an illumination bag 10, a collection bag 13 and a puncture feeding part with a hollow inner cavity, and the described puncture feeding part is an elastic cylinder with a hollow inner cavity Body 4, the elastic cylinder 4 can be made of silica gel or TPE. One end of the elastic cylinder 4 communicates with the puncture device 2 through a pipeline connection, and the other end communicates with one end of the dropping funnel 6 through a pipeline connection, and the protective sleeve 1 is sealed and sleeved on the puncture device 2 to ensure the hygiene and Safety. A first liquid stop clip 3 is provided on the connecting pipeline between the piercer 2 and the elastic cylinder 4 , and a one-way valve 5 is arranged on the connecting pipeline between the elastic cylinder 4 and one end of the dropping funnel 6 . The other end of the dropping funnel 6 is connected to the inlet end...

Embodiment approach 2

[0032] Such as figure 2 Compared with Embodiment 1, the plasma virus inactivation device shown uses a Y-shaped tee 14 instead of the elastic cylinder 4 . The Y-shaped tee 14 has 3 open ends, two of which are connected to the puncturer 2 and the drip funnel 6 through pipeline connections, and the other open end is sealed with a puncture cap 18 as a puncture dosing terminal, and other structures are the same as those in Embodiment 1.

[0033] The puncture cap 18 can be made of elastic materials such as silica gel or TPE, so that when the plasma virus inactivation operation is performed, the virus inactivation preparation can be injected into the dropping funnel 6 by directly puncturing the puncture cap 18, After the puncture and dosing is completed, the puncture cap 18 maintains a sealed state due to its elastic recovery, thereby avoiding the risk of contamination of the puncture and dosing.

Embodiment approach 3

[0035] Such as image 3 Compared with Embodiment 2, the plasma virus inactivation device shown uses a flow regulator 16 instead of the third liquid stop clamp 11 as the pipeline cut-off device on the second conduit 12 , and the other structures are the same as Embodiment 2. By adjusting the roller on the flow regulator 16 to squeeze the second conduit 12, not only can the on-off of the second conduit 12 be controlled, but also the fluid flow in the second conduit 12 can be adjusted conveniently.

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PUM

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Abstract

The invention provides a blood plasma virus inactivation device and method. The blood plasma virus inactivation device comprises a dripping bucket (6), an illumination bag (10), a collection bag (13) and a puncturing medicine adding part with a hollow inner cavity, wherein an outlet end of the illumination bag (10) is communicated with an inlet end of the collection bag (13) through a second guide pipe (12); the second guide pipe (12) is provided with a pipeline stopping device; the inlet ends of the puncturing medicine adding part, the dripping bucket (6) and the illumination bag (10) are connected through pipelines in sequence to form a sealed type pipeline system. After the puncturing medicine adding part, the dripping bucket (6) and the connection pipeline between the puncturing medicine adding part and the dripping bucket (6) are provided with light shielding structures, safety risks of pollution can be avoided when riboflavin is used as a light-sensitive agent to carry out virus inactivation, and the residue problem of the light-sensitive agent is avoided; the light-sensitive agent does not need to be adsorbed by utilizing a filter, so that the production cost is greatly reduced and the safety of blood transfusion is improved.

Description

technical field [0001] The invention relates to the technical field of plasma virus inactivation, in particular to a plasma virus inactivation device and method. Background technique [0002] With the development of science and technology and the improvement of medical conditions, people's awareness of transfusion-transmitted diseases is also increasing. In addition to immune factors, the unsafety of blood transfusion mainly comes from the contamination of pathogenic microorganisms and their metabolites, especially the spread of viruses has constituted the most important threat to the safety of blood transfusion. [0003] In my country, the main source of clinical blood transfusion is the voluntary blood donation of the population. Although strict inspection procedures are required before blood donation, the current virus detection technology also has the following limitations: (1) In the early stage of infection, before the appearance of virus serum markers , the current de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/02
CPCA61M1/0259
Inventor 蒋林李飞谢新强胡波
Owner SICHUAN NIGALE BIOTECH
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