Multi-response supramolecular hydrogel factor, hydrogel and preparation method thereof

A supramolecular hydrogel and hydrogel technology are applied in the field of hydrogel and its preparation, multi-responsive supramolecular hydrogel factor, which can solve the problems of limited application and achieve good anti-tumor and anti-inflammatory effects.

Active Publication Date: 2015-05-06
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the organogel dispersion medium is an organic solvent, its application is greatly limited.

Method used

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  • Multi-response supramolecular hydrogel factor, hydrogel and preparation method thereof
  • Multi-response supramolecular hydrogel factor, hydrogel and preparation method thereof
  • Multi-response supramolecular hydrogel factor, hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Weigh 1.84 g of Fc-COOH (8 mM), dissolve it in 250 ml of anhydrous dichloromethane, add 1.20 g of HOBt and 3.36 g of HBTU (8.8 mM each) under ice cooling. About 6 mL of triethylamine was slowly added dropwise. The reaction was stirred under an ice bath for 40 minutes to 1 hour. Thin layer chromatography (TLC) spot plate followed the reaction. After the reaction is complete, use saturated NaCO 3 , 5% HCl and distilled water were extracted once each. The extract was concentrated, purified by column chromatography, and dried in vacuo. 2.60 g of dark red compound (1) was obtained.

[0052] Weigh 1.6 g of compound (1), dissolve it in 50 mL of anhydrous dichloromethane, and add 0.86 g of H-Phe-OMe·HCl. Then 2 mL of triethylamine was added dropwise, and the reaction was carried out at room temperature for about 10 hours. TLC spot plate followed the reaction. After the reaction is complete, use saturated NaCO 3 , 5% HCl and distilled water were extracted once each. The...

Embodiment 2

[0056] Fc-COOH, HOBt and HBTU with a molar ratio of 1:1.2:1.2 were dissolved in anhydrous dichloromethane, and triethylamine was slowly added dropwise under ice cooling to pH 8.0-9.0. The reaction was stirred for 40 minutes to 1 hour. Thin layer chromatography (TLC) spot plate followed the reaction. After the reaction is complete, use saturated NaCO 3 , 5% HCl and distilled water were extracted once each. The extract was concentrated, purified by column chromatography, and dried in vacuo. The dark red compound (1) was obtained.

[0057] Compound (1) and H-Phe-OMe·HCl with a molar ratio of 1:1.2 were dissolved in anhydrous dichloromethane, then triethylamine was added dropwise to pH 8.0-9.0, and the reaction was stirred at room temperature for about 10 hours. TLC spot plate followed the reaction. After the reaction is complete, use saturated NaCO 3 , 5% HCl and water were extracted once each. The extract was concentrated, purified by column chromatography, and dried in v...

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Abstract

The invention discloses a multi-response supramolecular hydrogel factor, a hydrogel and a preparation method thereof. The method comprises the following operation steps: chemically modifying phenylalanine with activated ferrocene to obtain a ferrocene-phenylalanine hydrogel factor; and diluting a dimethylsulfoxide solution of the gel factor to 0.5%(w / v) with a PBS (phosphate buffer solution) having a pH value of 7.4, thus forming the hydrogel. The hydrogel prepared by the invention is simple and cheap, has multi-response property and simultaneously reserves the reduction-oxidation activity of ferrocene and the bioactivity of amino acid or short peptide, thus being hopefully used widely in the fields of such as medicine slow release, biosensing, response materials and the like.

Description

technical field [0001] The invention relates to a multi-response supramolecular hydrogel factor, a hydrogel and a preparation method thereof. In particular, it relates to a method for preparing multi-responsive, multifunctional supramolecular hydrogels through aromatic stacking and hydrogen bond self-assembly by using ferrocene to link aromatic phenylalanine through chemical modification. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. Traditional hydrogels are prepared by binding water molecules in a cross-linked polymer network. In the last ten years, with the rise of small molecule organogels (Chem.Rev.1997, 97, 3133), small molecule hydrogels (Chem.Rev.2004, 104, 1201) have gradually entered people's field of vision. Small molecule hydrogel is supramolecular hydrogel (Supramolecular hydrogel), which is composed of small molecules in water using non-covalent bonds to form a network-like supramolecular structure through self-assembly,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F17/02G01N27/30A61K47/24A61K9/06A61P35/00A61P29/00
Inventor 张翼孙志方李正元戴璇何庭
Owner CENT SOUTH UNIV
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