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Trimetazidine hydrochloride sustained release tablets and preparation method thereof

A technology of trimetazidine hydrochloride and sustained-release tablets, which is applied in the fields of pharmaceutical formulations, cardiovascular system diseases, drug combinations, etc., and can solve problems such as short maintenance time of effective blood drug concentration, large side effects, and inability to exert stable drug effects

Inactive Publication Date: 2016-08-24
ZHENGZHOU TAIFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After oral administration of these two kinds of coated trimetazidine tablets, trimetazidine is rapidly absorbed, reaching the peak plasma level in less than 2 hours, and the elimination half-life is about 6 hours, taking at least three times a day, the blood drug concentration in the body is easy to appear " "Peak and valley" phenomenon, not only makes the effective blood concentration maintenance time short, but also has large side effects, and the drug effect cannot be exerted smoothly

Method used

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  • Trimetazidine hydrochloride sustained release tablets and preparation method thereof
  • Trimetazidine hydrochloride sustained release tablets and preparation method thereof
  • Trimetazidine hydrochloride sustained release tablets and preparation method thereof

Examples

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Effect test

Embodiment 1

[0016] The following formula, according to the above-mentioned preparation method, is made into 4000 trimetazidine hydrochloride sustained-release tablets, and each sustained-release tablet finally obtained weighs about 200mg:

[0017]

[0018]

Embodiment 2

[0020] The following formula, according to the above-mentioned preparation method, is made into 4000 trimetazidine hydrochloride sustained-release tablets, and each sustained-release tablet finally obtained weighs about 200mg:

[0021]

[0022] Adopt the device in the second appendix XC dissolution test method of Chinese Pharmacopoeia 2010 edition, according to the test method of appendix XD release rate, get each slow-release tablet in embodiment 1-2 respectively, take water 500ml as dissolution medium, rotating speed 75 rev / min, operate according to the above method, take the corresponding solution at 1, 2, 3, 4, and 8 respectively, filter, accurately pipette 5ml of filtrate into a 10ml volumetric flask with a pipette gun, and use 0.1mol / L Dilute the sulfuric acid solution to the mark, shake well, measure the absorbance at 232nm by ultraviolet-visible spectrophotometry, and calculate the release amount.

[0023]

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Abstract

The invention belongs to the field of medicinal preparations, and in particular to trimetazidine hydrochloride sustained release tablets and a preparation method of the trimetazidine hydrochloride sustained release tablets. The trimetazidine hydrochloride sustained release tablets adopt hydrophilic gel as a sustained release framework material, and also contain a filling agent, a lubricating agent and other auxiliary materials. The prepared trimetazidine hydrochloride sustained release tablets are taken twice each day, 1 tablet each time, and the two rimetazidine hydrochloride sustained release tablets are taken at the breakfast time and the supper time respectively. Therefore, the trimetazidine hydrochloride sustained release tablets have the advantages that the drug can be slowly and uniformly released, thus the release rate is reduced, the peak time is delayed, the taking times each day is reduced, and the medicine-taking compliance of a patient is improved. In addition, the preparation method is simple in technology and easy to operate.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a trimetazidine hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] The chemical name of Trimetazidine is 1-(2,3,4-trimethoxybenzyl)piperazine, which can inhibit the oxidation of fatty acid (FFA), stimulate the oxidation of glucose, and to a certain extent resist myocardial ischemia Cells are protective. In recent years, trimetazidine hydrochloride has been widely used in the preventive treatment of angina pectoris and the auxiliary symptomatic treatment of vertigo and tinnitus. Angina is the more common type of ischemic heart disease. It is caused by coronary artery atherosclerosis and stenosis, resulting in insufficient coronary blood supply, temporary myocardial ischemia and hypoxia. It is a group of syndromes with precordial pain as the main clinical manifestation. It is the most common form of coronar...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/38A61K31/495A61P9/10
Inventor 鲁艳清梁鹏娟
Owner ZHENGZHOU TAIFENG PHARMA CO LTD
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