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Broad-spectrum antiparasitic drug nano-emulsion and preparation method thereof

A technology of anti-parasitic drugs and nanoemulsions, which is applied in the direction of anti-infective drugs, pharmaceutical formulations, drug combinations, etc., can solve the problems that are not conducive to clinical group drug administration, low bioavailability, and inconvenient drug administration, and achieve thermodynamic Good stability, good anti-corrosion performance, and long shelf life

Inactive Publication Date: 2016-08-17
高艳春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form of fenbendazol ivermectin compound preparation is tablet, which is inconvenient to administer and is not conducive to clinical mass administration, because its extremely low water solubility leads to low bioavailability, which directly affects the curative effect

Method used

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  • Broad-spectrum antiparasitic drug nano-emulsion and preparation method thereof
  • Broad-spectrum antiparasitic drug nano-emulsion and preparation method thereof
  • Broad-spectrum antiparasitic drug nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Weigh each drug component ethyl oleate 1.0g, polyoxyethylene hydrogenated castor oil 20g, 1,2-propanediol 2.5g, acetic acid 5g, ivermectin 0.6g, fenbendazole 12g, deionized Water 58.9g.

[0024] 2) Put the above weight of 1,2-propanediol, acetic acid, fenbendazole, and ivermectin in a beaker, mix them evenly with an electromagnetic stirrer until dissolved, then add ethyl oleate, polyoxyethylene hydrogenated castor oil , until the fenbendazole ivermectin is completely dissolved and the system is transparent;

[0025] 3) Slowly add deionized water to the mixture, and stir while adding; at the beginning, the system becomes liquid crystal phase or oil-in-water nanoemulsion, continue to drop and stir continuously, the system will suddenly become thinner, and the fluidity will increase. Large and completely transparent, the fenbendazole ivermectin nanoemulsion drug is prepared at this time.

Embodiment 2

[0027] 1) Take by weighing each drug component ethyl acetate 0.5g, castor oil polyoxyethylene ether 30.0g, 1,2-propanediol 2.0g, dimethyl sulfoxide 3g, ivermectin 1.2g, fenbendazole 20g, 43.3g deionized water;

[0028] 2) Place the ivermectin, fenbendazole, dimethyl sulfoxide, 1,2-propanediol, fenbendazole, ethyl acetate, castor oil polyoxyethylene ether of the above weight in a constant temperature magnetic stirrer On, stir until the system is transparent.

[0029] 3) Slowly add deionized water to the mixture, and stir while adding; at the beginning, the system becomes a liquid crystal phase or an oil-in-water nanoemulsion, continue to add and stir, the system will suddenly become thinner, and the fluidity will be reduced. Enlarged and completely transparent, the fenbendazole ivermectin nanoemulsion drug is prepared at this time.

Embodiment 3

[0031] 1) Weigh 7g of isopropyl myristate, 3.5g of ethanol, 0.3g of ivermectin, 6g of fenbendazole, 2g of acetic acid, 10g of Tween 80, and 71.2g of deionized water.

[0032] 2) First place the isopropyl myristate, Tween 80, ethanol, fenbendazole, and ivermectin of the above weight on a constant temperature magnetic stirrer, and mix well until the fenbendazole ivermectin is completely dissolved, the system is transparent.

[0033] 3) Slowly add deionized water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the amount of water added increases, the system will become viscous, and at this time the system may appear liquid crystal phase or For the oil-in-water nanoemulsion, continue to drop and stir continuously, the system will suddenly become thinner, the fluidity will increase, and it will be completely transparent. At this time, the fenbendazole ivermectin nanoemulsion drug will be prepared.

[0034] Embodiment 1~3 is tha...

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Abstract

The invention provides a broad-spectrum antiparasitic drug nanoemulsion and a preparation method thereof, which comprises the following components by weight percentage: 5-20% of fenbendazole, 0.3%-3% of ivermectin, and 0.5% of oil phase %-7%, co-surfactant 2%-12%, co-solvent 2%-5%, surfactant 10%-30%, deionized water 3-40%. The antiseptic property obtained by the invention is better, and it will not be mildewed or discolored after being placed at room temperature for three months. No additional preservatives are required, and the shelf life is long.

Description

technical field [0001] The invention relates to a broad-spectrum antiparasitic drug nanoemulsion and a preparation method thereof. Background technique [0002] Fenbendazole is a broad-spectrum anthelmintic drug with high efficiency and low toxicity. Very strong insecticidal effect. Fenbendazole is a widely used, safe and efficient benzimidazole anthelmintic drug in clinical practice, and is widely used in animal husbandry production. Ivermectin is a semi-synthetic macrolide antibiotic, which is the dihydrogen reduction product of avermectin. It is the best anthelmintic drug in the abamectin family, and ivermectin has an excellent effect on killing parasites on the body, and it also has the effect of inhibiting and killing gastrointestinal nematodes, which increases the anthelmintic spectrum after combined use. It covers almost all kinds of parasites except protozoa, and can expel internal and external parasites with one dose of medicine. The dosage form of fenbendazol i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/107A61P33/10A61K31/4184
CPCA61K31/4184A61K9/1075A61K31/7048A61K47/14
Inventor 高艳春
Owner 高艳春
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