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Preparation method of polydopamine/hyaluronic acid modified coating polylactic acid membrane

A technology of hyaluronic acid and polydopamine, which is applied in the field of polymer materials and biomaterials, can solve the problems of easy peeling of the coating layer, cumbersome process, and limited depth, and achieve rapid mineralization ability, mild method, and good biocompatibility The effect of sexual biodegradability

Inactive Publication Date: 2016-07-27
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used surface modification methods include surface coating, grafting, and plasma modification. The coating layer prepared by the coating method is easy to peel off, and the process of grafting modification is very cumbersome. The plasma treatment is limited due to the limited depth. restricted

Method used

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  • Preparation method of polydopamine/hyaluronic acid modified coating polylactic acid membrane
  • Preparation method of polydopamine/hyaluronic acid modified coating polylactic acid membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1, the preparation of polylactic acid base material

[0015] Put the PLA polymer into a Φ8mm×1mm stainless steel mold, preheat the mold filled with raw materials in a flat vulcanizer at 175°C for 5min, and at the same temperature, press at 10MPa for 5min to prepare the PLA matrix material.

Embodiment 2

[0016] Embodiment 2, the preparation of polydopamine surface modification material

[0017] Dopamine hydrochloride was dissolved in 10 mM Tris·HCl buffer (pH=8.5) to a concentration of 2 mg / mL. Immerse the PLA matrix material ultrasonically washed with ultrapure water into the above solution, react in a water bath constant temperature oscillator at 25°C for 24 hours for surface coating; take out the PLA matrix material after the reaction, and ultrasonically wash it with ultrapure water three to four times , 40 ℃ vacuum drying for 24h.

Embodiment 3

[0018] Embodiment 3, the preparation of hyaluronic acid-dopamine (HA-DA) surface modification material

[0019] Hyaluronic acid (HA), dopamine (DA), EDC, and NHS are subjected to amidation reaction at a feed ratio (molar ratio) of 1:2:2:4 to obtain HA-DA; dissolve HA-DA in hydrochloric acid solution (pH=2.0) and make its concentration reach 2mg / ml. Finally, immerse the PDA / PLA matrix material ultrasonically washed with ultrapure water into the above solution, react in a water bath constant temperature oscillator at 25°C for 24h for surface coating; take out the matrix material after the reaction, and ultrasonically wash it with ultrapure water for three To four times, vacuum dry at 40°C for 24h.

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Abstract

The invention provides a preparation method of a polydopamine / hyaluronic acid modified coating polylactic acid membrane. The method comprises the following steps: with polylactic acid (PLA) as a base material, coating the PLA surface with a layer of polydopamine coating for modification to obtain PDA / PLA based on the characteristic that the dopamine (DA) can be adhered to the surfaces of multiple materials; and performing further surface modification on the modified PDA / PLA base material through using DA grafted hyaluronic acid (HA-DA) prepared in advance to obtain a HA-DA / PDA / PLA composite material. The composite material prepared by the method provided by the invention has good degradability, cell adhesion and biocompatibility, and has a broad application prospect in the fields such as bone repair and packaging.

Description

technical field [0001] The invention relates to a preparation method of a polydopamine / hyaluronic acid modified coated polylactic acid film, which belongs to the technical field of polymer materials and biological materials. technical background [0002] With the development of bone tissue engineering materials, researchers have found that the interaction between cells and materials and the properties of material surfaces have a very important impact on the repair of bone defects. Although polymer bone tissue repair materials have many advantages in application, there are still some defects, such as: poor hydrophilicity, which is not conducive to cell adhesion, proliferation and differentiation, etc. Therefore, in the field of clinical medicine, it is not only necessary to develop biocompatibility For bone repair materials, it is also necessary to study how to improve the interaction between the material surface and cells and tissues. [0003] At present, the performance of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08L67/04C08B37/08A61L27/18A61L27/34A61L27/58B65D65/42B65D65/46
CPCA61L27/18A61L27/34A61L27/58A61L2400/18A61L2420/08A61L2430/02B65D65/42B65D65/466C08B37/0072C08J7/042C08J2367/04C08J2405/08C08J2479/00C08L67/04C08L79/00C08L5/08Y02W90/10
Inventor 石畅钮德宇赵增辉操莹李雅瑜沈佳丽施冬健
Owner JIANGNAN UNIV
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