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Moisture-proof stability type film coating premixing agent preparation method

A film coating and premix technology, which is applied in the directions of non-active ingredient medical preparations, pill delivery, sugar-coated pills, etc., can solve the problems of poor stability, uneven spraying, poor moisture-proof effect, etc. The effect of uniform spray and uniform thickness

Inactive Publication Date: 2017-11-17
赵顺全
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for preparing a moisture-proof and stable film coating premix in view of the disadvantages of poor stability of the traditional film coating premix, uneven spraying, and poor moisture-proof effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] According to the mass ratio of 1:2, weigh celery and winter bamboo shoots respectively, put them into a juicer and squeeze the juice for 5 minutes, filter after squeezing the juice, collect the celery dregs and winter bamboo shoots dregs, and mix them to obtain a mixed residue. The residue was soaked in 0.1% sodium sulfite solution for 40 minutes and then filtered to obtain the filter residue. The filter residue was washed 3 times with deionized water. After washing, it was placed in a vacuum drying oven and dried at 70°C for 10 hours. After drying, it was put into a pulverizer for crushing , and passed through a 120-mesh sieve to obtain a mixed powder; weigh 3g of sodium alginate and add it to a 1000mL three-necked flask, and add deionized water 100 times the quality of sodium alginate to the three-necked flask, and stir until the sodium alginate dissolves to obtain alginic acid Sodium solution, add 20% sodium alginate solution mass mixed powder to the sodium alginate s...

example 2

[0030] According to the mass ratio of 1:2, weigh celery and winter bamboo shoots respectively, put them into a juicer and squeeze the juice for 8 minutes, filter after squeezing the juice, collect the celery dregs and winter bamboo shoots dregs, and mix them to obtain a mixed residue. The residue was soaked in 0.1% sodium sulfite solution for 45 minutes and then filtered to obtain the filter residue. The filter residue was washed 4 times with deionized water. After washing, it was placed in a vacuum drying oven and dried at 75°C for 11 hours. After drying, it was put into a pulverizer for crushing , and passed through a 130-mesh sieve to obtain a mixed powder; weigh 4g of sodium alginate and add it to a 1000mL three-necked flask, and add deionized water 110 times the quality of sodium alginate to the three-necked flask, and stir until the sodium alginate dissolves to obtain alginic acid Sodium solution, add 25% sodium alginate solution mass mixed powder to the sodium alginate s...

example 3

[0033] According to the mass ratio of 1:2, weigh celery and winter bamboo shoots respectively, put them into a juicer and squeeze the juice for 10 minutes, filter after squeezing the juice, collect the celery residue and winter bamboo shoot residue, and mix them to obtain a mixed residue. According to the mass ratio of 1:8, mix the The residue was soaked in 0.1% sodium sulfite solution for 50 minutes and then filtered to obtain the filter residue. The filter residue was washed 5 times with deionized water. After washing, it was placed in a vacuum drying oven and dried at 80°C for 12 hours. After drying, it was put into a pulverizer for crushing , and passed through a 150-mesh sieve to obtain a mixed powder; weigh 5g of sodium alginate and add it to a 1000mL three-necked flask, and add deionized water 120 times the quality of sodium alginate to the three-necked flask, and stir until the sodium alginate dissolves to obtain alginic acid Sodium solution, add 30% sodium alginate sol...

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Abstract

The invention belongs to the technical field of pharmaceutic adjuvant preparation, and concretely relates to a moisture-proof stability type film coating premixing agent preparation method. The method comprises the following steps: juicing celery and winter bamboo shoot, mixing the materials to obtain mixed slag, placing a mixture in a bleaching solution for bleaching and washing, drying the mixture, crushing the mixture to obtain mixed powder, reacting the mixed powder and a sodium alginate solution to obtain a reaction object, mincing pigskin, repeatedly degreasing the pigskin by the sodium carbonate solution, extracting by water, collecting an extract and concentrating the extract to obtain a concentrate, mixing the concentrate, a reactant and sodium hyaluronate, and performing spray drying on the mixture, crushing the mixture, and sieving the mixture to obtain a moisture-proof stability type film coating premixing agent. The moisture-proof stability type film coating premixing agent can effectively solve the problems of poor stability, non-uniform spraying and poor moisture-proof effect of a traditional film coating premixing agent, the preparation steps are simple, the obtained film coating premixing agent has good stability and moistureproof effect, the spraying is uniform after usage, and no spray gun obstruction phenomenon is generated.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical excipients, and in particular relates to a preparation method of a moisture-proof and stable film coating premix. Background technique [0002] With the improvement of the level of pharmaceutical preparations, the continuous application of new pharmaceutical excipients and new technologies, the coating of pharmaceuticals has also undergone the evolution from sugar coating to film coating. Film coating is a coating technology developed in the early 1950s. Due to its advantages of good stability, short coating time, less weight gain, and good moisture resistance, it has gradually replaced sugar coating. In recent years, with the emergence of various new polymers and the advent of novel coating equipment, it has been popularized and developed. Film coating agent is generally composed of film-forming agent, plasticizer, solid additives and auxiliary agents. During production, th...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/38A61K47/36A61K47/26A61K47/10A61K9/36A61K9/38
CPCA61K9/2866A61K9/2873A61K47/10A61K47/26A61K47/36A61K47/38A61K47/42
Inventor 吴建盛开洋葛明月
Owner 赵顺全
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