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New applications of radix notoginseng and radix notoginseng extract to preparation of medicines for treating psoriasis

A new use and extract technology, applied in the field of Panax notoginseng, can solve the problems of psoriasis, difficult to control, rebound and other problems that ginsenoside Rb has not been retrieved, and achieve a stable and highly safe method of inhibiting vaginal epithelial mitosis. Effect

Inactive Publication Date: 2016-07-27
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of psoriasis is mostly treated with external agents such as glucocorticoid ointment for external use and preparations such as Tripterygium wilfordii Polyglycoside Tablets for internal use. Rebound phenomenon, difficult to control
[0004] At present, the inventor of this patent has found that ginsenoside Rb in the extract of Panax notoginseng has the effect of treating psoriasis in the research, and has not retrieved the literature report that the ginsenoside Rb in the extract of Panax notoginseng can be used to treat psoriasis

Method used

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  • New applications of radix notoginseng and radix notoginseng extract to preparation of medicines for treating psoriasis
  • New applications of radix notoginseng and radix notoginseng extract to preparation of medicines for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Grind Panax notoginseng into fine powder, add 10 times the weight of medicinal materials in 30% ethanol to moisten, soak for 30 minutes, ultrasonicate for 5 minutes, extract once with sealed pressure, extraction temperature is 50°C, maximum pressure is 0.4MPa, extraction is 15 minutes, The extract is filtered, concentrated, and placed at 4°C for 48 hours, filtered, centrifuged, adsorbed by the macroporous adsorption resin HPD-400, eluted with water and 30% to 90% ethanol in a gradient, and monitored online by an ultraviolet detector Eluate, collect qualified part (on-line monitoring, the part that meets claim 4 is qualified part), concentrate, add acetone solution, filter, collect precipitate, freeze-dry, add auxiliary material microcrystalline cellulose, hydroxypropyl cellulose , Carboxymethyl Starch Sodium, mix evenly, use 60% ethanol to make soft material, cross 20 mesh sieves to granulate, dry, granulate, add lubricant talcum powder, magnesium stearate and mix evenly...

Embodiment 2

[0028] Grind notoginseng into fine powder, add 95% ethanol to moisten, soak for 90 minutes, ultrasonic for 10 minutes, place in a pressurized extraction container, the extraction temperature is 100°C, the maximum pressure is 0.8MPa, sealed and pressurized for 3 times, each Add 20 times the amount of ethanol by the weight of the medicinal material at a time, extract for 40 minutes each time, combine the extracts, filter, concentrate, and place it at 9°C for 72 hours, filter, centrifuge, after being adsorbed by the macroporous adsorption resin HPD-400, rinse with water and 30%~90% ethanol by gradient elution, monitor eluent by ultraviolet detector online, collect qualified part (on-line monitoring, the part that meets claim 4 is qualified part), concentrate, add acetone solution, filter, Collect the precipitate, freeze-dry, add auxiliary materials starch and sucrose powder, mix evenly, use 60% ethanol to make soft material, pass through a 20-mesh sieve to granulate, dry, sieve, p...

Embodiment 3

[0031] Grind Panax notoginseng into fine powder, add 75% ethanol to moisten, soak for 60 minutes, ultrasonic for 8 minutes, place in a pressurized extraction container, seal and pressurize for 2 extractions, each time add 15 times the amount of ethanol by the weight of the medicinal material, each time Extracted for 30 minutes, combined the extracts, filtered, concentrated, placed at 9 ° C for 55 hours, filtered, centrifuged, after being adsorbed by the macroporous adsorption resin HPD-400, eluted with water and 30% to 90% ethanol in a gradient, On-line monitoring of the eluent by an ultraviolet detector, collection of qualified parts (on-line monitoring, the part that meets claim 4 is a qualified part), concentrated, added acetone solution, filtered, collected precipitate, freeze-dried, dissolved with water for injection, activated carbon processing, filtering, potting, and freeze-drying to prepare a freeze-dried injection.

[0032] Taking Rb1 as the reference substance, the ...

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Abstract

The invention relates to new applications of radix notoginseng and a radix notoginseng extract, namely new applications of radix notoginseng and the radix notoginseng extract to preparation of medicines for treating psoriasis, and in particular relates to a new application of a medicinal preparation with the content of ginsenosides Rb in the radix notoginseng extract not lower than 35% to preparation of medicines for treating psoriasis. The radix notoginseng ethanol extract obtained by extracting radix notoginseng with ethanol, adjusting the pH value of the extracting solution and carrying out adsorption with macroporous resin and carrying out elution can obviously inhibit mitosis of vaginal epithelia of mice and has obvious promoting effects on formation of granular layers of tail scales of C57 mice. The above results prompt that the radix notoginseng ethanol extract has the function of treating psoriasis.

Description

technical field [0001] The present invention relates to the new application of notoginseng, especially the new application of the extract of notoginseng, that is, the new application in the preparation of medicines for treating psoriasis. Background technique [0002] Psoriasis is a common chronic relapsing inflammatory skin disease. Typical skin lesions are erythema and scales. Therefore, traditional Chinese medicine also calls it "white rash" and "pine skin tinea". The incidence of psoriasis is high in our country. Studies have shown that psoriasis patients in our country account for about 3% of the world's population, and there is an increasing trend year by year. Psoriasis has obvious skin damage, conscious itching, often repeated attacks, protracted and difficult to heal, so it can only be controlled by drugs, using drugs to prevent each attack, and prolong the relief time as much as possible. At present, the pathogenesis of psoriasis is not yet clear. In traditional C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P17/06
CPCA61K36/258A61K9/0019A61K9/1652A61K9/19A61K9/2013A61K2236/33A61K2236/333A61K2236/51A61K2236/53A61K2236/55
Inventor 杨北妮林艳英黄源春邱丹兰杨良谭喜梅
Owner GUANGXI WUZHOU PHARMA GRP
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