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Metronidazole gel free of preservative and preparation method thereof

A preservative and metronidazole technology, applied in the field of biomedicine, can solve the problems of difficult long-term control, easy recurrence of the disease, misdiagnosed as bacterial blepharitis, etc., and achieves the effects of good stability and good safety.

Inactive Publication Date: 2016-07-20
ZHUHAI ESSEX BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, blepharitis caused by mites has not been paid enough attention in clinical ophthalmology. It is often misdiagnosed as bacterial blepharitis, and conventional antibiotic treatment often has no obvious effect
[0003] The treatment of skin diseases caused by demodex includes veratrum cream, topical application of compound Baibu cream, etc., but the condition is prone to relapse and it is difficult to control it for a long time
Metronidazole is clinically used to treat dermatitis caused by mites, but the cream formula currently used can only be used for external use on the skin and cannot be used for eye treatment. Due to the special location of blepharitis, some existing irritating Creams are not suitable for eyelid margins

Method used

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  • Metronidazole gel free of preservative and preparation method thereof
  • Metronidazole gel free of preservative and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preservative-free metronidazole ophthalmic gel is prepared by the following steps: (a) after dissolving 0.2% carbomer and 0.2% hypromellose in 10% water according to the proportion, Add 0.2% triethanolamine to the carbomer solution and stir until clear, then add the dissolved hypromellose solution, mix well, record it as liquid A, and set aside; (b) mix 0.08% disodium hydrogen phosphate, 0.02 % sodium dihydrogen phosphate, 2.5% glycerin, and 0.05% metronidazole were added to an appropriate amount of water in turn, stirred evenly to dissolve, recorded as liquid B, and set aside; (c) Mix the two solutions A and B evenly, and the remaining Continue to make up to 100% with water, sterilize at 121°C for 30 minutes under hot pressure, and cool naturally to obtain the gel product.

Embodiment 2

[0017] A preservative-free metronidazole ophthalmic gel is prepared by the following steps: (a) after dissolving 0.1% carbomer and 0.1% hypromellose in 10% water respectively according to the proportion, Add 0.1% triethanolamine to the carbomer solution and stir until clear, then add the dissolved hypromellose solution, mix well, record it as liquid A, and set aside; (b) mix 0.05% disodium hydrogen phosphate, 0.02 % sodium dihydrogen phosphate, 1% glycerin, and 0.01% metronidazole were added to an appropriate amount of water in turn, stirred evenly to dissolve, recorded as B liquid, and set aside; (c) Mix the two solutions A and B evenly, and the remaining Continue to make up to 100% with water, sterilize at 121°C for 30 minutes under hot pressure, and cool naturally to obtain the gel product.

Embodiment 3

[0019] A preservative-free metronidazole ophthalmic gel is prepared by the following steps: (a) after dissolving 0.4% carbomer and 0.3% hypromellose in 15% water according to the proportion, Add 0.8% triethanolamine to the carbomer solution and stir until clear, then add the dissolved hypromellose solution, mix well, record it as liquid A, and set aside; (b) mix 0.2% disodium hydrogen phosphate, 0.1 % sodium dihydrogen phosphate, 2.5% glycerin, and 0.1% metronidazole were added to an appropriate amount of water in turn, stirred evenly to dissolve, recorded as liquid B, and set aside; (c) Mix the two solutions A and B evenly, and the remaining Continue to make up to 100% with water, sterilize under hot pressure at 121°C for 30 minutes, and cool naturally to obtain the gel product, which is designated as A3.

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Abstract

The invention provides metronidazole gel free of a preservative and relates to the field of biological medicines. The metronidazole gel consists of the following components in percentage by mass: 0.01-0.1% of metronidazole, 0.1-0.5% of carbomer, 0.1-0.5% of hydroxypropyl methylcellulose, 0.1-1% of triethanolamine, 0.01-0.2% of sodium hydrogen phosphate, 0.02-0.2% of sodium dihydrogen phosphate, 1-3% of glycerinum and the balance of water. Correspondingly, the invention further provides a preparation method of the gel. Compared with the prior art, the metronidazole ophthalmic gel of the technical scheme obtained through tests and studies has relatively small influence on variation of medicinal substances (metronidazole), and is relatively good in stability; meanwhile, as no preservative is used, the metronidazole gel is relatively good in security when being used by a patient.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a metronidazole gel and a preparation method thereof. Background technique [0002] Demodex is a small parasitic mite, only two species of Demodex exist in nature and there are many species found in the human body, namely Demodex folliculorum and Demodex sebum. Demodex is a kind of permanent parasitic mite that parasitizes the hair follicles and sebaceous glands of various mammals. The infection rate in the human body is different in the world. Foreign scholars report that the infection rate of the population is 27% to 100%. Infections were also common, with infection rates ranging from 0.8% to 81.0%. Demodex mites inhabit the eyelashes. Symptoms range from no eye discomfort to various types and degrees of eye discomfort, the most common of which are: itching, foreign body sensation, dry eyes, red eyes, increased eye secretions, and repeated eyelash loss. , Trichiasis, etc. Demodex ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4164A61K47/32A61P33/14
CPCA61K31/4164A61K9/0048A61K9/06A61K47/32A61K47/38
Inventor 曲伟谭佳佳李海才王振恒戴佩旻
Owner ZHUHAI ESSEX BIO PHARMA
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