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A drug-loaded canaliculus plug

A technology of lacrimal canaliculus and drug loading, which is applied in the direction of drug equipment, ophthalmic treatment, and other medical equipment, etc. It can solve the problems of lacrimal canaliculus obstruction, tear stasis, and easy inflammation, so as to prevent lacrimal duct inflammation, relieve inflammation, prevent Effects of epiphora

Active Publication Date: 2018-09-28
YIPURUN SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing canaliculus embolus completely blocks the canaliculus, causing tears to accumulate in the canaliculus, which can easily cause inflammation

Method used

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  • A drug-loaded canaliculus plug
  • A drug-loaded canaliculus plug
  • A drug-loaded canaliculus plug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as Figure 1a with Figure 1b As shown, the medicated punctal plug 100 includes a cylindrical main body 101 extending along a central axis. One end of the main body 101 has a fixing snap ring 102 extending radially outward from the main body 101 and passing through the fixing snap ring 102 A plurality of tear holes 103 extend. After the drug-loaded lacrimal canaliculus plug 100 of the present invention is implanted into the lacrimal canaliculus, the fixing ring 102 is located at the proximal end of the lacrimal canaliculus, that is, close to the eyeball position, and plays a role of fixing in the lacrimal canaliculus to prevent drug loading. The canaliculus plug 100 is washed away by tear fluid. The extension length of the fixed snap ring 102 along the central axis is 0.1 mm-0.3 mm, and the outer diameter of the fixed snap ring 102 is 0.1 mm-0.4 mm larger than the outer diameter of the main body 101 to better play a fixed role. The tear hole 103 is a through hole, w...

Embodiment 2

[0034] Such as figure 2 As shown, the medicated punctal plug 200 includes a cylindrical main body 201 extending along a central axis. One end of the main body 201 has a fixing snap ring 202 extending radially outward from the main body 201 and passing through the fixing snap ring 202. A plurality of tear holes 203 extend, and the other end of the main body 201 has another fixed snap ring 204 extending radially outward from the main body 201, and a plurality of tear holes 205 extend through the other fixed snap ring 204. When the drug-loaded lacrimal canaliculus embolus 200 of the present invention is implanted in the lacrimal canaliculus, the fixed clasp 202 is at the proximal end of the lacrimal canaliculus, that is, close to the eyeball position, and the other fixed clasp 204 is at the distal end of the lacrimal canaliculus, that is, far away Both of the eyeball positions serve to fix the lacrimal canaliculus to prevent the lacrimal canalicular plug 200 carrying the medicine ...

Embodiment 3

[0036] As shown in FIG. 3, the medicated punctal plug 300 includes a cylindrical body 301 extending along a central axis. A tear hole 303 extends through the main body 301. The tear hole 303 is a through hole formed as a tapered hole extending along the central axis. When the drug-loaded lacrimal canaliculus plug 300 of the present invention is implanted into the lacrimal canaliculus, the excess tear of the eye passes through the lacrimal passage 303, and then flows along the inner conical surface of the main body 301 to the nasolacrimal duct, and finally from the nasolacrimal duct In order to prevent excessive tears from staying in the lacrimal canaliculus and cause lacrimal inflammation, and prevent the occurrence of orbital tears. The cone bottom of the tapered hole is far away from the proximal end of the lacrimal canaliculus. When excess tear fluid is discharged, the tapered hole can make the tear fluid flow quickly to the nasolacrimal duct without stagnation. The diamet...

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Abstract

The invention relates to a medicine carrying punctual plug, which comprises a cylindrical main body extending along a center shaft, wherein the main body is formed by biodegradable polymer materials; medicine grooves are formed in the surface of the main body; and antibiotic medicine and biodegradable polymers are mixed and are contained in the medicine carrying grooves. The medicine carrying punctual plug has the advantages that the release of the antibiotic medicine is controlled through the biodegradable polymers; and the medicine can be released in a long treatment period such as half a month or one month according to a certain release curve such as uniform release, or release in a release speed regulating mode according to the disease condition of xerophthalmia or the release in a mode that that the release speed is high when the medicine carrying punctual plug is implanted into the lacrimal duct for a short time, and then the release speed is decelerated along with the disease symptom relief in future. After the xerophthalmia is relieved, the medicine carrying punctual plug starts to gradually degrade; and finally, carbon dioxide and water are generated and are discharged out from the nasolacrimal canal, so that the inflammation can be effectively relieved.

Description

Technical field [0001] The present invention relates to the lacrimal canaliculus, and more specifically to a drug-loaded lacrimal canaliculus plug. Background technique [0002] Dry eye syndrome refers to abnormal tear quality or quantity or abnormal dynamics caused by any reason, leading to a decrease in tear film stability, accompanied by eye discomfort and ocular surface tissue lesions. It is a general term for a variety of diseases, also known as corneal dryness disease. Common symptoms include dry eyes, easy tiredness, itchy eyes, foreign body sensation, burning sensation, sticky discharge, fear of wind, photophobia, and sensitivity to external stimuli; sometimes the eyes are too dry and there is not enough tears, but it stimulates reflex The secretion of tears results in frequent tears. In more severe cases, the eyes will be red, swollen, congested, keratinized, and corneal epithelium will be broken and filaments will adhere. This damage can cause corneal and conjunctival ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F9/00A61M37/00
Inventor 黄彬谢建李建军
Owner YIPURUN SHANGHAI BIOTECH CO LTD
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