Breast patch and preparation method thereof

A patch and breast technology, applied in medical science, surgery, etc., can solve the problems of weak muscle tissue, exacerbation of infection and rejection, displacement of prosthesis, etc., and achieve the effect of reducing morbidity, reducing rejection and inducing regeneration

Inactive Publication Date: 2016-07-13
SHAANXI RUISHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially for Ogilvy & Mather removal patients and breast cancer patients, the breast muscle tissue is usually weak due to the removal of a large area of ​​breast tissue. After the breast prosthesis is implanted, there will be complications such as prosthesis displacement and sagging. These complications will also aggravate postoperative infection and rejection, causing great pain to patients

Method used

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  • Breast patch and preparation method thereof
  • Breast patch and preparation method thereof
  • Breast patch and preparation method thereof

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preparation example Construction

[0041] On the other hand, an embodiment of the present invention provides a method for preparing a breast patch as described above, see Figure 5 ,include:

[0042] Step 1) remove the adipose tissue and connective tissue of mammalian membrane tissue, and obtain the membrane tissue after preliminary treatment;

[0043] Step 2) Soaking the preliminarily treated membrane tissue in an alkaline solution for decellularization to obtain the decellularized membrane tissue;

[0044] Step 3) Soaking the decellularized membrane tissue in an organic solvent for degreasing treatment to obtain the degreased membrane tissue;

[0045] Step 4) Surface modifying and drying the degreased membrane tissue to obtain a breast patch.

[0046] Since the mammalian membrane tissue itself has a double-layer structure with a dense layer and a loose layer, the natural double-layer structure of the animal membrane tissue can be preserved by performing decellularization on the animal membrane tissue.

[004...

Embodiment 1

[0090] S101, removing the fat tissue and connective tissue on the surface of the bovine pericardium, cleaning the foreign matter on the surface, and obtaining the bovine pericardium after preliminary treatment;

[0091] S102. Soak the preliminarily treated bovine pericardium in 30% hydrogen peroxide solution for 3 hours for disinfection, then shake and wash with physiological saline for 1 hour, and then wash with water until the pH value is 6.0.

[0092] S103. Soak the bovine pericardium obtained in step S102 with 5 times the amount of 1M sodium hydroxide for 0.5 h to obtain decellularized bovine pericardium;

[0093] S104. Wash the decellularized bovine pericardium for 15 minutes with three parts of phosphate buffer solution whose mass is 15 times that of the decellularized bovine pericardium, so that the pH of the water on the bovine pericardium is Value is 6.0;

[0094] S105. Degreasing the bovine pericardium obtained in step S104 with 5 times the amount of isopropanol for...

Embodiment 2

[0104] S101, removing the adipose tissue and connective tissue on the surface of the sheep small intestine mucosa, cleaning the foreign matter on the surface, and obtaining the sheep small intestine mucosa after preliminary treatment;

[0105] S102. Soak the preliminarily treated sheep small intestinal mucosa in 60% hydrochloric acid solution for 0.5 h for disinfection, then shake and wash with phosphate buffer for 2 h, and then wash with water until the pH value is 7.0.

[0106] S103. Soak the sheep small intestinal mucosa in step S102 with 5 times the amount of 0.5M sodium hydroxide for 3 hours to obtain the decellularized sheep small intestinal mucosa;

[0107] S104. Wash the decellularized sheep small intestinal mucosa for 12 minutes with three parts of phosphate buffer solution whose mass is 15 times that of the decellularized sheep small intestinal mucosa, so that the pH value of the water on the sheep small intestinal mucosa is 8.0 ;

[0108] S105, degreasing the sheep...

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Abstract

The invention relates to the technical field of tissue engineering, in particular to a breast patch and a preparation method thereof.The breast patch is implanted between a breast prosthesis and an organism, rejection reaction of the organism can be reduced, the morbidity of capsule contracture is reduced, pain of patients is relieved, a supporting and fixing function can be achieved, and the prosthesis is prevented from moving or drooping.The breast patch is membrane tissue of a two-layer structure.The two-layer structure comprises a compact layer and a loose layer.The compact layer is formed by densely distributing collagen bundles in a staggered mode.The loose layer is formed by loosely distributing collagen bundles in a staggered mode.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a breast patch and a preparation method thereof. Background technique [0002] In recent years, breast plastic surgery is one of the most common types of plastic surgery. The most common types of breast plastic surgery are: breast augmentation, breast sagging correction, breast reconstruction and breast reconstruction; in these breast plastic surgery , It is usually necessary to implant breast prostheses into the pectoralis major muscle. After surgery, patients often experience rejection of foreign bodies, resulting in capsular contractures such as breast stiffness and pain. Especially for Ogilvy patients and breast cancer patients, usually due to the removal of large areas of breast tissue, the breast muscle tissue is relatively weak, and after the breast prosthesis is implanted, complications such as prosthesis displacement and sagging will occur. These complication...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L31/04A61L31/14
CPCA61L31/005A61L31/044A61L31/14C08L89/00
Inventor 张锐利
Owner SHAANXI RUISHENG BIOTECH
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