Harmless treatment method for erythrocin strain residues

Abstract

The invention discloses a method for treating erythromycin slag, which comprises the following steps: (1) placing the slag to be treated in a fermenter, adding other yeast fermentation medium components, and mixing to obtain slag water system, sterilized; (2) take the yeast liquid with OD value not less than 0.6, add it into the fungus residue water system in step (1) according to the inoculum amount of 2-10% (v / v), at a temperature of 30-30 Ferment for 36-72 hours at 35°C, tank pressure 0.02-0.07MPa, air flow 0.2-1.0L / min, system pH 4.5-6.5, to obtain fermentation broth; (3) Separation of solid-liquid fermentation broth , to be precipitated and dried. The method of the present invention can effectively remove the erythromycin residue in the bacteria residue, effectively solve the pollution problem of the erythromycin residue, and the bacteria residue treated per unit volume is much, the cost is low, and the solid dry yeast powder produced at the same time can be used for other products such as feed , Organic nutrients in the fermentation industry, suitable for industrial applications.

Description

Technical field [0001] The invention relates to a harmless treatment method of erythromycin bacterial residue. Background technique [0002] Erythromycin residue is the main raw material of starch, soybean meal, corn syrup, and the waste residue produced by adding erythromycin strain-red Saccharomyces erythromycin after aerobic deep fermentation to produce erythromycin, in addition to containing a lot of water Its main components are residual starch and other sugars, residual soybean powder, a large amount of mycelium, some inorganic substances and a small amount of erythromycin residue (the concentration in the stock solution of bacteria residue is about 600-1400U / mL), depending on the water content Different, the content of dry matter is about 10-100g / L (depending on the specific production method, it fluctuates greatly). [0003] The residue of erythromycin bacteria emits a special peculiar smell, slightly bitter. Because of the high content of organic matter in the bacterial ...

AI Technical Summary

Problems solved by technology

The Chinese patent application with the application number 2007100527715 adopts the method of fermentation of erythromycin with bacteria residue reused. This treatment method will eventually result in erythromycin residue with antibiotics and metabolic intermediates, which cannot ultimately achieve harmless treatment. , that is, the residual antibiotics and metabolic intermediates in the bacterial residue cannot be finally removed, and there are still ecological and health hazards

The Chinese patent application with the application number 20130162936.X discloses a method of anaerobic fermentation using anaerobic bacteria, which can effectively remove erythromycin, but the treatment concentration of the bacteria residue is only 10-20kg / m 3 The erythromycin slag treated per unit volume is too little, and the treatment time is long, which leads to high cost and does not use large-scale industrial scale production