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Preparation and application of a polymer vesicle hydrogel drug carrier

A technology of polymer vesicles and hydrogels, which can be used in medical preparations without active ingredients, medical preparations containing active ingredients, and drug combinations, etc., which can solve the problems of difficult to release drugs at fixed points and lack of fixed shapes. , to achieve the effect of great social and economic benefits, and good oxygen permeability

Active Publication Date: 2019-12-10
湖南知时生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polymer vesicles usually exist in the form of a solution, lacking a fixed shape, and it is difficult to achieve targeted release of drugs

Method used

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  • Preparation and application of a polymer vesicle hydrogel drug carrier
  • Preparation and application of a polymer vesicle hydrogel drug carrier
  • Preparation and application of a polymer vesicle hydrogel drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Add 25mg HEP and 100μL DEA solution into an open reaction vessel (beaker), add 10mL distilled water, stir until the solution is transparent and uniform, then add 5mM vitamin C, after it is completely dissolved, add 5mM hydrogen peroxide, and initiate polymerization at 60°C 2h, stop stirring at the same time, after the reaction is completed, oxygen gas is introduced to inhibit polymerization. Then add 22 mg of alanine, add 22 mg of EDC, slightly adjust the pH value to 5.5-6, and react at room temperature for 4 hours. After the obtained solution is left to stand for 1-2 hours, the precipitate is removed to obtain a polymer vesicle solution. The effective particle size of the obtained vesicles was 218.0, and the polydispersity coefficient was 0.075.

[0044] Mix the above polymer vesicle aqueous solution with HEMA monomer at a ratio of 4:1, add 0.05% w / v photoinitiator (I2959), stir evenly, pour it into a mold, react in a 365nm ultraviolet reactor for 45min, and then plac...

Embodiment 2

[0047]Add 25mg HEP and 100μL DEA solution into an open reaction vessel (beaker), add 10mL distilled water, stir until the solution is transparent and uniform, then add 5mM vitamin C, after it is completely dissolved, add 5mM hydrogen peroxide, and initiate polymerization at 60°C 2h, stop stirring at the same time, after the reaction is completed, oxygen gas is introduced to inhibit polymerization. Then add 22 mg of alanine, add 22 mg of EDC, slightly adjust the pH value to 5.5-6, and react at room temperature for 4 hours. After the obtained solution is left to stand for 1-2 hours, the precipitate is removed to obtain a polymer vesicle solution. The effective particle size of the obtained vesicles was 218.0, and the polydispersity coefficient was 0.075.

[0048] Mix the above-mentioned polymer vesicle aqueous solution with HEMA monomer at 2:1, add 0.05% w / v photoinitiator (I2959), stir well, pour it into a mold, react in a 365nm ultraviolet reactor for 45min, and then place it...

Embodiment 3

[0051] Add 25mg HEP and 100μL DEA solution into an open reaction vessel (beaker), add 10mL distilled water, stir until the solution is transparent and uniform, then add 5mM vitamin C, after it is completely dissolved, add 5mM hydrogen peroxide, and initiate polymerization at 60°C 2h, stop stirring at the same time, after the reaction is completed, oxygen gas is introduced to inhibit polymerization. Then add 22 mg of alanine, add 22 mg of EDC, slightly adjust the pH value to 5.5-6, and react at room temperature for 4 hours. After the obtained solution is left to stand for 1-2 hours, the precipitate is removed to obtain a polymer vesicle solution. The effective particle size of the obtained vesicles was 218.0, and the polydispersity coefficient was 0.075.

[0052] Mix the above-mentioned polymer vesicle aqueous solution with HEMA monomer at a ratio of 1:1, add 0.05% w / v photoinitiator (I2959), stir evenly, pour it into a mold, react in a 365nm ultraviolet reactor for 45min, and...

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Abstract

The invention discloses preparation and application of a high-molecular vesicle hydrogel drug carrier. The preparation method comprises the following steps of preparing a high-molecular polymer solution, preparing a high-molecular vesicle solution, preparing high-molecular vesicle composite hydrogel and loading a drug into the high-molecular vesicle composite hydrogel. According to the preparation and application of the high-molecular vesicle hydrogel drug carrier, a macromolecule and monomer pair method is used for assembling high-molecular vesicles, the assembled high-molecular vesicles are composed of two parts, the first part is biomacromolecules with sulfonate radicals and carboxylate radicals, and the second part is poly(2-(diethylamino)ethyl methacrylate) with tertiary amino; an aqueous solution containing the high-molecular vesicles is mixed with hydroxyethyl methacrylate monomers, a photoinitiator I2959 is added for initiated polymerization, the composite hydrogel drug carrier is formed, and the drug is loaded into the hydrogel drug carrier in an adsorption mode. Meanwhile, the invention discloses application of the high-molecular vesicle hydrogel drug carrier in medicament for the eyes, and good drug controlled-release capacity is embodied.

Description

[0001] field of invention [0002] The invention belongs to the field of new materials, and in particular relates to the preparation and application of polymer vesicle composite hydrogel. Background technique [0003] Many diseases are treated with drugs. In this process, too low drug concentration cannot play a therapeutic role; too high drug concentration will cause side effects and even damage normal tissues and organs. In addition, the therapeutic effect also depends on whether the drug can remain in the affected area for a sufficient time. In order to improve the efficacy of drugs, it is often necessary to increase the drug concentration and the number of administrations, but too much drugs will damage normal tissues and organs. [0004] Hydrogel is a polymer network structure that swells in water, has good biocompatibility, is soft and elastic after absorbing water, and is not easy to cause tissue damage. In addition, the water-soluble environment of hydrogel is simil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K9/127A61K31/5383A61K47/32A61K47/36A61P27/02
CPCA61K9/0002A61K9/06A61K9/1273A61K31/5383A61K47/32A61K47/36
Inventor 王昕胡小红陈频
Owner 湖南知时生物科技有限公司
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