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A Japanese encephalitis vaccine composition and preparation method thereof

A vaccine composition, Japanese encephalitis technology, applied in the directions of biochemical equipment and methods, microorganisms, pharmaceutical formulations, etc., can solve the problem of no protection effect of SA-14-14-2 live attenuated vaccine, etc., and achieve clinical results. Good application prospect, high specific antibody level, good immunogenicity and immunoprotective effect

Inactive Publication Date: 2019-07-19
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on a suitable adjuvant that can improve the protective effect of SA-14-14-2 live attenuated vaccine

Method used

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  • A Japanese encephalitis vaccine composition and preparation method thereof
  • A Japanese encephalitis vaccine composition and preparation method thereof
  • A Japanese encephalitis vaccine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 vaccine composition of the present invention

[0036] The preparation method is as follows:

[0037] Take 10 parts of porcine Japanese encephalitis live vaccine, add 100ml PBS buffer solution [PBS solution is 0.2mol / L (pH7.4) phosphate buffer saline] after dissolving, add 10ml Montanide TM The Gel water-based vaccine adjuvant is mixed with a disposable sterile plastic syringe and vibrated until the live vaccine sample is completely dissolved to obtain the vaccine composition of the present invention.

[0038] The beneficial effects of the present invention are illustrated below by specific drug efficacy tests.

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Abstract

The invention provides Japanese encephalitis (JE) vaccine composition. The JE vaccine composition comprises a JE virus antigen of immunization effective quantity and water based vaccine adjuvant. The invention further provides a preparing method and application of the JE vaccine composition. The vaccine composition has good immunogenicity and immunizing protection. The immune effect of the JE vaccine composition is remarkably superior to that of single pig JE live vaccine and other live vaccine diluted by immunologic adjuvant. The clinical application prospects are good.

Description

technical field [0001] The invention relates to a Japanese encephalitis vaccine composition and a preparation method thereof, belonging to the field of veterinary biological products. Background technique [0002] Japanese encephalitis (Japanese encephalitis, JE), also known as epidemic Japanese encephalitis, Japanese encephalitis B, referred to as JE, is a zoonotic disease caused by Japanese encephalitis virus (JEV). Insect-borne diseases. Japanese encephalitis virus mainly causes nervous system diseases in humans and reproductive disorders in pigs, which poses a great threat to human health and breeding industry. [0003] There is no effective drug for treating Japanese encephalitis in the breeding industry so far, and the practical way is to cut off the infection link. However, JEV can proliferate in a variety of mosquitoes, and the infection mode varies with the local ecological environment, so it is unrealistic to control mosquitoes. With the rapid development of my ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/12A61K39/39A61P31/14
CPCA61K39/12A61K39/39A61K2039/5254A61K2039/55555C12N2770/24134
Inventor 伍锐王侨曹三杰文心田赵勤黄小波文翼平颜其贵马晓平冯瑶柴春霞
Owner SICHUAN AGRI UNIV
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