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Breast cancer diagnostic marker combination and application and determination method thereof

A diagnostic marker and assay method technology, applied in the field of breast cancer diagnostic marker combination, application and determination, can solve the problems of low early disease sensitivity and low early disease detection accuracy, achieve high sensitivity and specificity, improve clinical Therapeutic effect, the effect of improving the therapeutic effect

Active Publication Date: 2016-06-15
HUMAN METABOLOMICS INST INC
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Problems solved by technology

However, this patent also has the disadvantages of low early disease sensitivity and low detection accuracy for early disease

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  • Breast cancer diagnostic marker combination and application and determination method thereof
  • Breast cancer diagnostic marker combination and application and determination method thereof
  • Breast cancer diagnostic marker combination and application and determination method thereof

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Embodiment Construction

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0036] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0037] Embodiments of the present invention will be specifically explained below in conjunction with the accompanying drawings.

[0038] Embodiments of the present invention apply chromatography-mass spectrometry technology to detect metabolites in serum or plasma samples to find diagnostic ...

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Abstract

The present invention discloses a breast cancer diagnostic marker combination and application and a determination method thereof, and particularly relates to 13 difference metabolites (Aspartate, Glutamate, 5-Oxoproline, Cystine, Glutamine, Cysteine, Hypotaurine, Asparagine, Glycerolphosphate, Glycerophosphocholine, Arachidonate, Glyoxylate and pentosidine) and a combination thereof as a breast cancer early detection and diagnosis marker and application thereof and a determination method of the diagnosis marker, and the determination method is a metabonomic analysis method based on liquid / gas chromatography-mass spectrometry of plasma / serum of a patient with breast cancer. The diagnostic marker combination has the characteristics of high sensitivity and high specificity, has high sensitivity and specificity for early diagnosis of breast cancer, can be used for early detection of breast cancer, can gain time for patients to begin treatment as soon as possible, and improves clinical therapeutic effects.

Description

technical field [0001] The invention relates to the field of biotechnology, and relates to a breast cancer diagnostic marker combination, application and determination method thereof. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, and its incidence is increasing year by year. The long-term survival rate of female breast cancer patients is closely related to the time and stage of disease discovery and diagnosis. Early detection and early diagnosis of breast cancer are the key to improving the curative effect and can greatly reduce the mortality rate of breast cancer. Currently the most widely used method for screening breast cancer is mammography, which has a sensitivity of 54%-77%. Other methods such as thermography and magnetic resonance imaging (MRI) are also commonly used, but are generally less sensitive. Therefore, it is very important to find biomarkers for early diagnosis of breast cancer. Now identified tumor marke...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 贾伟谢国祥赵爱华刘佳健
Owner HUMAN METABOLOMICS INST INC
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