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Clopidogrel hydrogen sulfate medicinal composition and medicinal application thereof

A technology of clopidogrel hydrogen sulfate and composition, applied in the field of biomedicine, can solve the problems such as no related reports of clopidogrel hydrogen sulfate, and achieve the effect of strong anticonvulsant effect

Inactive Publication Date: 2016-06-15
贺玉皓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between clopidogrel bisulfate and its pharmaceutical composition and anticonvulsants

Method used

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  • Clopidogrel hydrogen sulfate medicinal composition and medicinal application thereof
  • Clopidogrel hydrogen sulfate medicinal composition and medicinal application thereof
  • Clopidogrel hydrogen sulfate medicinal composition and medicinal application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Grind the green fruit (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in n-butanol extract with D101 type macroporous resin for impurity removal, first elute 8 column volumes with 10% ethanol, then elute 10 column volumes with 70% ethanol, collect 70% eluate, concentrate under ...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] Kunming mice, SPF grade, weighing 20±2g, were provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0029] 1.2 Drugs and reagents

[0030] Clopidogrel bisulfate was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Pentylene tetrazole, Alfa Aisha Chemical Co., Ltd.; 3-mercaptopropionic acid, Beijing Bailingwei Technology Co., Ltd.; Tween-80, Tianjin Fuchen Chemical Reagent Factory.

[0031] 1.3 Instruments

[0032] PM4600 electronic balance (Mettler-Toledo, Switzerland); BP221S 1 / 100,000 electronic balance (Sartorius, Germany); JL-C2 electric stimulator (manufactured by Shanghai Jialong Teaching Instrument Factory); XZC-4B rotary rod fatigue tester (Equipment Station of Shandong Academy of Medical Sciences).

...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of clopidogrel hydrogen sulfate and its medical use. The pharmaceutical composition of clopidogrel hydrogen sulfate provided by the invention contains clopidogrel hydrogen sulfate and a novel natural product compound ( Ⅰ), when clopidogrel bisulfate and compound (I) are used alone, both have anticonvulsant effect; when clopidogrel bisulfate and compound (Ⅰ) are used in combination, the anticonvulsant effect is stronger, and can be developed into The medicine has outstanding substantive features and significant progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of clopidogrel hydrogen sulfate, in particular to a pharmaceutical composition of clopidogrel hydrogen sulfate and its medical application. Background technique [0002] Clopidogrel bisulfate is a platelet aggregation inhibitor. Can inhibit platelet aggregation induced by other agonists by blocking the expansion of platelet activation caused by released ADP. Clopidogrel does not inhibit the activity of phosphodiesterase. Clopidogrel acts by irreversibly modifying platelet ADP receptors. The longevity of platelets exposed to clopidogrel was affected. The recovery rate of normal function of platelets is related to the renewal of platelets. [0003] So far, there has been no report on the correlation between clopidogrel bisulfate and its pharmaceutical composition and anticonvulsants. Contents of the invention [0004] The object of the present invention is to provid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A61K31/336A61K31/4365A61P25/08
CPCC07D493/04A61K31/336A61K31/4365
Inventor 贺玉皓
Owner 贺玉皓
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