Immature bitter orange extract product and preparation method thereof and application of immature bitter orange extract product for delaying skin aging

A citrus citrus extract and a technology of citrus aurantium, applied in the field of citrus aurantium extract and its preparation, and delaying skin aging, can solve the problems that the citrus citrus extract has not been reported, and achieve the promotion of type I collagen expression and delay Skin aging, the effect of suppressing expression

Inactive Publication Date: 2016-06-15
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The use of citrus citrus extract

Method used

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  • Immature bitter orange extract product and preparation method thereof and application of immature bitter orange extract product for delaying skin aging
  • Immature bitter orange extract product and preparation method thereof and application of immature bitter orange extract product for delaying skin aging
  • Immature bitter orange extract product and preparation method thereof and application of immature bitter orange extract product for delaying skin aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Take the decoction pieces of Fructus Aurantii, pulverize, and pass through a No. 2 sieve to obtain raw materials with a particle size of 24 mesh. Weigh the Fructus Aurantii powder and add 5 times of 30% aqueous ethanol solution, extract in a water bath at 20° C. for 1 h, and filter to obtain a filtrate. The filtrate was concentrated under vacuum at 20°C to obtain an extract. The contents of naringin and neohesperidin in the extract of Citrus aurantium were detected by HPLC to be 20.78% and 13.83%, and the content of synephrine was 2.12%.

Embodiment 2

[0068] Take the decoction pieces of Fructus Aurantii, pulverize, and pass through a No. 3 sieve to obtain raw materials with a particle size of 50 mesh. Weigh the above Fructus Citriens powder and add 20 times of 90% ethanol aqueous solution, extract in a water bath at 70° C. for 3 hours, and filter to obtain a filtrate. The filtrate was concentrated under vacuum at 60°C to obtain an extract. The contents of naringin and neohesperidin in the extract of Fructus Citrus Fructus were detected by HPLC were 17.35% and 22.65%, and the content of synephrine was 1.69%.

Embodiment 3

[0070] Take the decoction pieces of Fructus Aurantii, pulverize, and pass through a No. 4 sieve to obtain raw materials with a particle size of 60 mesh. Weigh the Fructus Aurantii powder and add 15 times of 60% aqueous ethanol solution, extract in a water bath at 50° C. for 2 hours, and filter to obtain a filtrate. The filtrate was concentrated under vacuum at 45°C to obtain an extract. The contents of naringin and neohesperidin in the extract of Fructus Citrii Fructus were detected by HPLC to be 29.27% ​​and 26.82%, respectively, and the content of synephrine was 3.03%.

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PUM

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Abstract

The invention relates to the field of plant extraction, and especially relates to an immature bitter orange extract product, a preparation method and an application of the immature bitter orange extract product for delaying skin aging. The provided extraction method improves the extraction technological parameters, aiming at the anti-aging effect. The obtained immature bitter orange extract product can obviously reduce the injury of ultraviolet ray on fibroblast and keratinocyte, the expression of type I collagen in fibroblast can be promoted, the expression of MMP-1 is inhibited, and efficacy for delaying skin aging can be performed. The immature bitter orange extract product can reach a purpose of delaying skin aging from epidermis and dermis, and research insufficiency of health care efficacy of the immature bitter oranges can be made up. The immature bitter orange extract product provides powerful support for development of anti-aging food, health products and cosmetics.

Description

technical field [0001] The invention relates to the field of plant extraction, in particular to a citrus citrus extract and its preparation method and application in delaying skin aging. Background technique [0002] Aging is a process in which the functions of various organs in the body generally decrease gradually. During the aging process of the body, the skin easily reveals signs of aging due to direct contact with the external environment. Skin aging generally has two manifestations: natural aging and photoaging. [0003] The general trend of natural aging skin thickness is thinning, epidermal renewal slows down, the barrier function of the stratum corneum decreases, and the junction with the dermis becomes flat. Epidermal cells gradually become flattened, keratinocyte activity decreases, and the hydration capacity of the stratum corneum decreases. Natural skin aging is determined by genetic factors as well as hormone levels in the body. [0004] Photoaging, on the ...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/60A61K8/41A61Q19/08A61K36/752A61K31/7048A61K31/133A61P17/18A61P17/16A61K8/9789
CPCA61K8/41A61K8/602A61K8/97A61K31/133A61K31/7048A61K36/752A61K2236/333A61K2236/51A61Q19/08A61K2300/00
Inventor 华洋林魏晓丽寇忠京李泓颖唐健
Owner INFINITUS (CHINA) CO LTD
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