A preparation method of antibacterial polysaccharide hemostatic cotton-based gauze

Abstract

The invention discloses a preparation method of an antibacterial polysaccharide hemostatic cotton based gauze. The method comprises the following steps: firstly, preparing a quaternized polyethyleneimine and a hydroformylation polysaccharide cross-linking agent which have an anti-bacterial function; and then mixing and foaming the quaternized polyethyleneimine, the hydroformylation polysaccharide cross-linking agent and chitosan hydrochloride, uniformly coating the surface of a preprocessed gauze with foaming liquid, and carrying out freeze drying to obtain the antibacterial polysaccharide hemostatic cotton based gauze. After being compounded, polysaccharide hemostatic cotton and the preprocessed gauze are combined closely, do not fall off, have high intensity, and are suitable for compression hemostasis and binding at wounds. Moreover, compared with a common gauze, the antibacterial polysaccharide hemostatic cotton based gauze has the effects of inhibiting growth of microorganisms and inhibiting bacteria when stopping bleeding. In addition, a sponge coating the surface of the gauze uses safe and nontoxic polysaccharide as the cross-linking agent, so that the intensity and the blood stopping effect of the hemostatic cotton based gauze are further improved.

Description

technical field [0001] The invention relates to a preparation method of antibacterial polysaccharide hemostatic cotton-based gauze, which belongs to the field of biomedical materials. Background technique [0002] At present, various new medical biological hemostatic materials are constantly emerging. Commonly used clinical biological hemostatic materials include oxidized cellulose, gelatin sponge, chitosan and calcium alginate fiber. These hemostatic materials all have different hemostatic effects, but have a single function and are expensive. [0003] In Chinese patent CN 202604936 U, a gelatin sponge hemostatic cotton is prepared; in Chinese patent CN102908651 A, an oxidized cellulose hemostatic material is prepared; these hemostatic cottons have a good hemostatic effect, but their functions are relatively single and do not have Antibacterial and anti-inflammatory effects. In Chinese patent CN 101816802 A, a chitosan-based medical dressing is prepared. This hemostatic ...

AI Technical Summary

Problems solved by technology

These hemostatic materials have different hemostatic effects, but they are single-function and expensive

[0003] In Chinese patent CN 202604936 U, a gelatin sponge hemostatic cotton is prepared; in Chinese patent CN102908651 A, an oxidized cellulose hemostatic material is prepared; these hemostatic cottons have a good hemostatic effect, but their functions are relatively single and do not have Antibacterial and anti-inflammatory effects

In Chinese patent CN 101816802 A, a chitosan-based medical dressing is prepared. This hemostatic cotton has antibacterial effect, but its antibacterial ability is limited and its mechanical strength is low

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