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Preparation method of a highly sensitive functionalized silver nanoparticle-doped aniracetam molecularly imprinted electrochemical sensor

A technology of silver nanoparticles and molecular imprinting, which is applied in the direction of material electrochemical variables, scientific instruments, instruments, etc., can solve the problems of poor cross-linking rigidity, functional monomers, cross-linking agents and template molecules cannot be properly matched, and low sensitivity, etc. problem, to achieve the effect of simple production, excellent sensitivity and simple equipment

Inactive Publication Date: 2018-03-13
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers, cross-linking agents and template molecules cannot be properly matched, and the rigidity of the cross-linking is also poor.

Method used

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  • Preparation method of a highly sensitive functionalized silver nanoparticle-doped aniracetam molecularly imprinted electrochemical sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of Aniracetam Molecularly Imprinted Electrochemical Sensor

[0017] To 10.0mL solvent ethanol, add 0.6mmol template molecule aniracetam, 6.0mmol functional monomer dihydromyrcenol, 3.2mmol crosslinking agent hydrocortisone acetate, 0.9mmol initiator azobis Isobutyronitrile and 0.0600g of dopant decylthiol functionalized silver nanoparticles, each adding a chemical reagent ultrasonically dissolved for 8 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode with a diameter of 2 mm. The template molecules were eluted with a mixed solvent of formic a...

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Abstract

The invention discloses a preparation method of a high-sensitivity functionalized silver nanoparticle-doped aniracetam MIECS (Molecular Imprinting Electrochemical Sensor). The preparation method is characterized by taking aniracetam as a template molecule, dihydromyrcenol as a functional monomer, hydrocortisone acetate as a coupling agent and decyl mercaptan functionalized silver nanoparticles as a doping agent, thus preparing the high-sensitivity decyl mercaptan functionalized silver nanoparticle-doped aniracetam MIECS. An analysis method is simple and practical, and the disadvantages of complexity, expensive price of equipment and low sensitivity of a previous analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a high-sensitivity functionalized silver nanoparticle-doped aniracetam molecularly imprinted electrochemical sensor. Background technique [0002] Aniracetam (Aniracetam) is a kind of central nervous system restoration drug, which selectively acts on the central nervous system through the blood-brain barrier, and has a good therapeutic effect on memory loss in middle-aged and elderly people and memory loss after cerebrovascular disease. However, long-term or excessive use of such drugs can lead to side effects such as excessive lethargy, renal insufficiency, liver function damage, acute liver failure, and liver necrosis. [0003] The methods for the determination of Aniracetam include ultraviolet spectroscopy, high performance liquid chromatography and so on. However, these methods have the disadvantages of high cost, time-consuming, and lo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 陈其锋余会成韦贻春雷福厚李浩谭学才
Owner GUANGXI UNIV FOR NATITIES
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