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Method for preparing ceramic biological material with abrasion self-remediation function in in-vivo environment

A technology of internal environment and biomaterials, applied in the field of biomedical engineering and biomedical materials, can solve problems affecting the quality of life of patients, abnormal noise of artificial organs, large friction coefficient, etc., achieve good lubrication, improve quality of life, and increase usage The effect of longevity

Inactive Publication Date: 2016-05-25
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although passed in Al 2 o 3 Doping metal elements in ceramics can increase Al 2 o 3 The fracture toughness of ceramics, but its friction coefficient is still large, and the friction noise has not been reduced. It is used in the manufacture of artificial joints or artificial intervertebral discs. After clinical implantation, these artificial organs will produce abnormal noise during service, making patients uncomfortable , affecting the patient's quality of life

Method used

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  • Method for preparing ceramic biological material with abrasion self-remediation function in in-vivo environment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A. Raw material preparation: Copper powder and zirconia powder are used as raw materials, and the ratio is recorded as: 99% zirconia powder and 1% copper powder according to mass percentage. Mix the powder raw materials evenly in a planetary ball mill.

[0022] B. Put the dry raw material powder into a graphite mold, and carry out hot-press sintering under the protection of argon. The reaction hot-press sintering temperature is 1100°C, the hot-press sintering time is 2 hours, and the hot-press sintering pressure is 25MPa. A zirconia ceramic biomaterial doped with metal copper and capable of self-repairing wear in vivo, wherein the doping ratio of metal copper is 1%, and the ceramic density reaches more than 90%.

Embodiment 2

[0024] A. Raw material preparation: Copper powder and zirconia powder are used as raw materials, and the ratio is recorded as: 90% zirconia powder and 10% copper powder according to mass percentage. Mix the powder raw materials evenly in a planetary ball mill.

[0025] B. Put the dry raw material powder into a graphite mold, and carry out hot-press sintering under the protection of argon. The reaction hot-press sintering temperature is 1100°C, the hot-press sintering time is 3 hours, and the hot-press sintering pressure is 30MPa. A zirconia ceramic biomaterial doped with metal copper and capable of self-repairing wear in vivo, wherein the doping ratio of metal copper is 10%, and the density of the ceramic reaches more than 90%.

Embodiment 3

[0027] A. Raw material preparation: chromium powder and zirconia powder are used as raw materials, and the ratio is recorded as: 99% zirconia powder and 1% chromium powder according to mass percentage. Mix the powder raw materials evenly in a planetary ball mill.

[0028] B. Put the dry raw material powder into a graphite mold, and carry out hot-press sintering under the protection of argon. The reaction hot-press sintering temperature is 1400°C, the hot-press sintering time is 3 hours, and the hot-press sintering pressure is 25MPa. A zirconia ceramic biomaterial doped with metal chromium and capable of self-repairing wear in vivo, wherein the doping ratio of metal chromium is 1%, and the density of the ceramic reaches more than 90%.

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Abstract

The invention discloses a method for preparing a ceramic biological material with an abrasion self-remediation function in an in-vivo environment. The ceramic biological material comprises the following raw materials in percentage by mass: 90-99% of zirconia powder (alumina powder) and 1-10% of metal powder. The method comprises the following steps: putting the raw materials into a planet ball mill, uniformly mixing according to a wet method, drying, and performing hot-pressing sintering at 1100-1800 DEG C for 0.5-3 hours in the presence of an inert atmosphere. The metal doping mass ratio in the prepared ceramic biological material is within 1-10%; when the ceramic biological material is used as a friction accessory (such as an artificial joint and an artificial intervertebral disc) in a human body, because of fiction abrasion and corrosion, a layer of protein biological membrane can be formed on a friction interface, along with friction, the protein biological membrane can be converted into a graphite layer, and friction and abrasion of the ceramic biological material can be effectively reduced. Abrasion remediation of the ceramic biological material can be achieved, and the ceramic biological material is good in abrasion self-remediation function in the human body.

Description

Technical field: [0001] The invention belongs to the field of biomedical engineering and biomedical materials, in particular to a method for preparing a ceramic biomaterial with wear self-repairing function in the internal environment. Background technique: [0002] Artificial joint replacement is currently the most effective method for treating diseases such as osteoarthritis. The artificial joint has been in service for a long time in the body (more than 10 years, and may even reach more than 30 years), and the relative frictional movement of the head-socket structure can reach several Tens of millions of times, the wear caused by friction will not only change the size of the head-socket structure, but the main hazard is that various wear debris generated during the wear process will lead to inflammation and prosthesis failure [1. MatevzTopolovec, AndrejC, IngridMilos. Metal-on-metal vs. metal-on-polyethylenetotalhiparthroplastytribologicalevaluationofretrievedcomponentsan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C29/12C22C1/05A61L27/04
CPCA61L27/04A61L2430/24A61L2430/38C22C1/051C22C29/12
Inventor 冷永祥邓乔元谢东王进陈俊英杨苹黄楠
Owner SOUTHWEST JIAOTONG UNIV
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