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Nano-silver antibacterial gel with chitosan-poloxamer as gel matrix and preparation method and application of nano-silver antibacterial gel

A nano-silver antibacterial and gel matrix technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the secondary injury of patients, high cytotoxicity and side effects, cell Toxicity and other problems, to achieve the effect of promoting healing and good biocompatibility

Active Publication Date: 2016-05-25
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Nowadays, there are many types of antibacterial gel products used for burn wound treatment, but their cytotoxicity is generally high, and some even have high cytotoxicity
In the process of promoting the healing of burn wounds, its high cytotoxicity may cause relatively large side effects and cause secondary damage to patients

Method used

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  • Nano-silver antibacterial gel with chitosan-poloxamer as gel matrix and preparation method and application of nano-silver antibacterial gel
  • Nano-silver antibacterial gel with chitosan-poloxamer as gel matrix and preparation method and application of nano-silver antibacterial gel
  • Nano-silver antibacterial gel with chitosan-poloxamer as gel matrix and preparation method and application of nano-silver antibacterial gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of the nano-silver antibacterial gel of low toxicity, stable taking chitosan-poloxamer as gel matrix

[0025] (1) Preparation of nano-silver stock solution: add 37.8mg of silver nitrate to 100mL ultrapure water under magnetic stirring, add 30mg of poloxamer 407 after it is fully dissolved, wait for 2min to fully dissolve the poloxamer in water , add 30mg of trisodium citrate, and irradiate with ultraviolet light for 4 hours to make a nano-silver stock solution with a silver content of 240μg / mL.

[0026] (2) Prepare 17.55 mL of glacial acetic acid solution with 200 μL at room temperature, then add 250 μL of nano-silver stock solution and 200 μL of glycerin and stir well, then add 20 mg of poloxamer and 0.36 g of chitosan Sugar prepared chitosan-poloxamer sol containing nano-silver, and finally added NaHCO 3 The solution adjusts the pH of the sol to about 6. After a period of gelation, a low-toxic and stable nano-silver antibacterial gel wi...

Embodiment 2

[0027] Embodiment 2: the preparation of the nano-silver antibacterial gel of low toxicity, stable taking chitosan-poloxamer as gel matrix

[0028] (1) Nano silver stock solution, chitosan-poloxamer antibacterial gel are prepared with embodiment 1;

[0029] (2) Prepare 16.4 mL of glacial acetic acid solution with 200 μL at room temperature, then add 1 mL of nano-silver stock solution and 600 μL of glycerin and stir well, then add 100 mg of poloxamer and 0.42 g of chitosan Sugar prepared chitosan-poloxamer sol containing nano-silver, and finally added NaHCO 3 The solution adjusts the pH of the sol to about 6. After a period of gelation, a low-toxic and stable nano-silver antibacterial gel with chitosan-poloxamer as the gel matrix is ​​obtained, the pH is between 5.4 and 5.8, and it is light yellow or grayish yellow translucent Thick liquid, uniform and delicate gel, no phase separation, suitable viscosity, good spreadability, non-greasy, not easy to adhere to the wet wound sur...

Embodiment 3

[0030] Embodiment 3: the preparation of the nano-silver antibacterial gel of low toxicity, stable taking chitosan-poloxamer as gel matrix

[0031] (1) Nano silver stock solution, chitosan-poloxamer antibacterial gel are prepared with embodiment 1;

[0032] (2) Prepare 15mL of glacial acetic acid solution with 200μL at room temperature, then add 2mL of nano-silver stock solution and 1mL of glycerin and stir evenly, then add 200mg of poloxamer and 0.48g of chitosan in turn Prepare chitosan-poloxamer sol containing nano-silver, and finally add NaHCO 3 The solution adjusts the pH of the sol to about 6. After a period of gelation, a low-toxic and stable nano-silver antibacterial gel with chitosan-poloxamer as the gel matrix is ​​obtained. It is light yellow or grayish-yellow translucent thick liquid, and the gel is uniform and delicate. , no phase separation, suitable viscosity, good spreadability, non-greasy, not easy to adhere to the wet wound surface.

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Abstract

The invention belongs to the technical field of nano-silver antibacterial gel, and discloses a preparation method and application of nano-silver antibacterial gel with chitosan-poloxamer as the gel matrix. The nano-silver antibacterial gel is characterized by being prepared through the following specific steps of adding poloxamer to a silver nitrate aqueous solution to be evenly stirred, adding trisodium citrate, irradiating the mixture with ultraviolet light after even stirring to obtain a nano-silver stock solution, adding a glacial acetic acid solution and glycerol to the nano-silver stock solution to be evenly stirred, adding poloxamer and chitosan to obtain nano-silver chitosan-poloxamer sol, regulating pH, and standing to make the mixture gelated to obtain the nano-silver antibacterial gel. According to the gel, chemical crosslinking is replaced with physical crosslinking, the problem that because harmful chemical reagents and other cross-linking agents are introduced, cytotoxicity rises is avoided, nano-silver is introduced by using chitosan and poloxamer in a combined mode as a carrier, the gel is stable and low in toxicity, and the gel can be applied to scalded wound surfaces and has great benefits for prognosis and outcome of patients.

Description

technical field [0001] The invention belongs to the technical field of nano-silver antibacterial gel, in particular to a nano-silver antibacterial gel with chitosan-poloxamer as a gel matrix, a preparation method and application thereof. Background technique [0002] Nowadays, there are many types of antibacterial gel products used for burn wound treatment, but their cytotoxicity is generally high, and some even have high cytotoxicity. In the process of promoting the healing of burn wounds, its high cytotoxicity may cause relatively large side effects and cause secondary harm to patients. For example, according to the in vitro cytotoxicity comparison of 18 kinds of nano-silver medical products sold in the current medical market by people such as Huang Qingquan, it is found that the cytotoxicity of 5.6% of the products is grade 3; and the cytotoxicity of 77.8% of the products is level 4. According to the in vitro cytotoxicity test of nine kinds of medical devices containing...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K47/36A61K47/34A61K9/06A61P17/02A61K31/722A61K47/10
CPCA61K9/06A61K31/722A61K33/38A61K47/10A61K47/36A61K2300/00
Inventor 胡云睿李达恒余学飞沈志勇刘叔文沈梅游文玮
Owner SOUTHERN MEDICAL UNIVERSITY
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