Mass spectrometry information-based biological characteristic image identification method

Abstract

The invention provides a mass spectrometry information-based biological characteristic image identification method. The method comprises the steps as follows: firstly, chromatography-mass spectrometry analysis is carried out on a sample, and m / z, t and I of compounds in the sample are obtained; with m / z and t as coordinates, the mass spectrometry signal intensity of the compounds is represented by chromatic values of points; a generated m / z-t-I image is suitable for identification of the sample; biological characteristics in the sample are converted into spatial characteristics by extracting overall spatial information and local spatial information, for example, outlines, textures or colority from the image; the sample in which the composition or abundance of each compound is different displays specific spatial information; and closely clustered data points are selected, the characteristic region of the image is found out; and similarity analysis is carried out for sample identification and nature judgment. The mass spectrometry information-based biological characteristic image identification method breaks through a method for identifying the sample by mass spectrometry signal intensity or a method for identifying the sample by only mass spectrometry information of a few of index compounds and greatly improves the mass spectrometry-based complicated sample identification ability.

Description

technical field [0001] The invention relates to a complex sample rapid identification method based on visual mass spectrum information technology. Background technique [0002] The identification of complex biological samples is one of the most challenging topics in various research fields today. Complex samples contain multiple chemical components with a wide variety of compounds with widely varying physical and chemical properties. Using the information of these compounds to identify complex samples and classify them has a strong demand in the fields of animal and plant species judgment and disease diagnosis. Mass spectrometry is an effective technique that can be used to identify complex samples. Especially when combined with chromatographic technology, it can separate and detect complex samples, and obtain the mass spectrum information of parent ions and product ions of each compound in the sample, such as mass-to-charge ratio and charge number, etc. Its advantages are...

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is a mass spectrometry feature image recognition method based on mass spectrometry information. The present invention changes the traditional method and converts the chromatogram-mass spectrometry information of biological samples into m / z-t-I images to reflect the mass difference of each compound. Through Identify spatial information such as contours and textures of images to improve the efficiency of identifying biological samples

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