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A kind of preparation method of jiubing extract

A technology for saving Bingying and extracts, which is applied in the field of extraction and separation of medicinal active ingredients, can solve the problems of long extraction time and large energy consumption, and achieves the effects of high extraction efficiency, simple process and fast extraction speed.

Active Publication Date: 2020-01-07
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a high-efficiency, low-energy-consumption, and suitable preparation method for industrialized production of the extract of basilicum, which overcomes the shortcomings of the existing extraction methods such as long extraction time and high energy consumption.

Method used

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  • A kind of preparation method of jiubing extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Jiubing should be cleaned, washed, baked at 60°C for 3 hours, and crushed to 100 mesh for later use. Weigh 300 g and place it in a 5L flash extraction tank, add water 10 times the weight of the raw material to extract at room temperature, rotate at a speed of 5000 r / min, extract for 10 min for the first time, filter out the liquid medicine, then add water 8 times the weight of the raw material, and extract 5 min, combined extracts;

[0022] The extract was subjected to coarse filtration, fine filtration, and microfiltration, and then was concentrated through a polyamide nanofiltration membrane with a molecular weight cut-off of 300. The operating pressure was 1 MPa. After concentration to a solid content of 30%, 29.50 g of the product was obtained by spray drying. Process flow chart such as figure 1 shown.

[0023] According to the content determination method of the extract of the Chinese Pharmacopoeia 2010 edition, the mass fraction of pelicin glucoside and syringin...

Embodiment 2

[0025] Jiubing should be cleaned, washed, baked at 60°C for 3 hours, and crushed to 100 mesh for later use. Weigh 300 g and put it in a 5L flash extraction tank, add water 12 times the weight of the raw material to extract at room temperature, rotate at 4000 r / min, extract for 10 min for the first time, filter out the liquid medicine, then add water 10 times the weight of the raw material, and extract 5 min, combined extracts;

[0026] The extract was subjected to coarse filtration, fine filtration, and microfiltration, and then concentrated through a polyamide nanofiltration membrane with a molecular weight cut-off of 300. The operating pressure was 1 MPa. After concentration to a solid content of 30%, the product was spray-dried to obtain 30.24 g.

[0027] According to the content determination method of the 2010 edition of the Chinese Pharmacopoeia, the content of the extract of Jiubiying was analyzed and detected by HPLC. The mass fraction of pelican glucoside was 17.10%, ...

Embodiment 3

[0029] Jiubing should be cleaned, washed, baked at 60°C for 3 hours, and crushed to 100 mesh for later use. Weigh 300 g and place it in a 5L flash extraction tank, add water 12 times the weight of the raw material to extract at room temperature, rotate at 8000 r / min, extract for 8 min for the first time, filter out the liquid medicine, then add water 8 times the weight of the raw material, and extract 5 min, combined extracts;

[0030] The extract was subjected to coarse filtration, fine filtration, and microfiltration, and then concentrated through a polyamide nanofiltration membrane with a molecular weight cut-off of 500. The operating pressure was 1 MPa. After concentration to a solid content of 30%, the product was spray-dried to obtain 31.37 g.

[0031] According to the content determination method of the 2010 edition of the Chinese Pharmacopoeia, the content of the extract of Jiubiying was analyzed and detected by HPLC. The mass fraction of pelican glucoside was 16.87%, ...

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Abstract

The present invention discloses an ilex rotunda Thunb extract preparation method. The method steps are as follows: 1) pretreatment of a medicinal material, to be more specific, an ilex rotunda Thunb medicinal material is cleaned, selected, washed, baked at 60 DEG C for 3 to 5 hours, and pulverized to 50 to 100 mesh for standby use; 2) flash extraction, to be more specific, the pretreated medicinal material and an extraction solvent are mixed and put into a flash extraction tank, a speed governor is started to control the rotation speed in 4000-10000r / min, the extraction time is 1-20min, the number of extraction times is 1 to 5, and after the extraction is finished, a filtrate is collected after filtration; 3) membrane concentration, to be more specific, after crude filtration, fine filtration and microfiltration of an extract liquid, the extract liquid passes through a nanofiltration membrane with the cutoff molecular weight of 100 to 500 for concentration, and the operating pressure is 0.5-3MPa; and 4) spray drying, to be more specific, an ilex rotunda Thunb extract can be obtained by spray drying of a membrane concentrate liquid. The method is high in technical process efficiency, low in energy consumption, and suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting and concentrating jiubing, and belongs to the technical field of extraction and separation of medicinal active ingredients. Background technique [0002] Jiubiying is the dry bark of Ilex holly, a synonym of Baimuxiang. It is a traditional Chinese herbal medicine in southern my country. It has the functions of purging fire and detoxification, cooling blood to stop bleeding, promoting qi and relieving pain, etc. It is often used to treat summer heat and fever. , sore throat, damp-heat diarrhea, abdominal pain, rheumatic arthralgia, etc. Preliminary studies have shown that the main active ingredients of Gyubing extract are triterpenoids and triterpenoid saponins such as syringin and pelicin, which have the effects of clearing away heat and detoxification, reducing swelling and relieving pain, and are effective against both aerobic and anaerobic bacteria. It has good antibacterial effect. [0003] Traditio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P31/04A61P29/00A61P11/04A61P1/12G01N30/02
CPCA61K36/185A61K2236/33A61K2236/333A61K2236/39A61K2236/51G01N30/02G01N2030/027
Inventor 段迪傅玉萍李宇袁诚王龙书卢嘉伟王小妹刘春芳王婷李金华
Owner GUANGZHOU HANFANG PHARMA
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