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An intelligent magnetic single-hole hollow nanosphere and its preparation method and application

A technology of magnetic nanoparticles and nanospheres, which is applied in the direction of preparation of microspheres, preparations for in vivo tests, and medical preparations of non-active ingredients. It can solve the problem of lack of self-assembly construction methods and complex interactions of magnetic nanoparticles. Problems, to achieve the effect of common equipment, low price, and improved magnetic performance

Active Publication Date: 2018-10-16
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complex interaction between magnetic nanoparticles, there is a lack of self-assembly construction methods. So far, only some simple assembly structures, such as nanoclusters, nanowires and nanorings, have been prepared.

Method used

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  • An intelligent magnetic single-hole hollow nanosphere and its preparation method and application
  • An intelligent magnetic single-hole hollow nanosphere and its preparation method and application
  • An intelligent magnetic single-hole hollow nanosphere and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1) 0.9mg / ml, 5-nm Fe 3 o 4 For nanoparticles, 1.5 mg / ml of polyethylene glycol with a weight average molecular weight of 6000 is dissolved in 10 mL of dichloromethane, and the resulting mixed solution is used as a dispersed phase;

[0051] The continuous phase is a 0.25 wt% aqueous solution of sodium dodecylsulfonate.

[0052]Inject the dispersed phase and the continuous phase into different channels of the microfluidic chip, the injection rate of the dispersed phase is 50uL / min; the injection rate of the continuous phase is 5mL / min; the dispersed phase is sheared by the continuous phase in the microfluidic chip Cut into highly monodisperse magnetic monoemulsion droplets of 7 µm.

[0053] 2) The single-emulsion droplet system obtained in step 1) is stored in a refrigerator at 5° C. for 40 minutes, and the single-emulsion droplet evolves into a double-emulsion droplet. Then, under the environment of 15° C., the solvent in the double emulsion droplets was completely ev...

Embodiment 2

[0056] 1) 0.9mg / ml, 5-nm Fe 3 o 4 For nanoparticles, 1.0 mg / ml of polyethylene glycol with a weight average molecular weight of 6000 is dissolved in 10 mL of dichloromethane, and the resulting mixed solution is used as a dispersed phase;

[0057] The continuous phase is a 0.25 wt% aqueous solution of sodium dodecylsulfonate.

[0058] Inject the dispersed phase and the continuous phase into different channels of the microfluidic chip, the injection rate of the dispersed phase is 50uL / min; the injection rate of the continuous phase is 5mL / min; the dispersed phase is sheared by the continuous phase in the microfluidic chip Cut into highly monodisperse magnetic monoemulsion droplets of 7 µm. The droplet was stored in a refrigerator at 5°C for 40 minutes, and the single emulsion droplet evolved into a double emulsion droplet.

[0059] 2) The single-emulsion droplet system obtained in step 1) was placed in an environment of 15°C for 30 hours to completely volatilize the solvent i...

Embodiment 3

[0062] 1) 0.9mg / ml, 5-nm Fe 3 o 4 For nanoparticles, 0.5 mg / ml of polyethylene glycol with a weight average molecular weight of 6000 is dissolved in 10 mL of dichloromethane, and the resulting mixed solution is used as a dispersed phase;

[0063] The continuous phase is a 0.25 wt% aqueous solution of sodium dodecylsulfonate.

[0064] Inject the dispersed phase and the continuous phase into different channels of the microfluidic chip, the injection rate of the dispersed phase is 50uL / min; the injection rate of the continuous phase is 5mL / min; the dispersed phase is sheared by the continuous phase in the microfluidic chip Cut into highly monodisperse magnetic monoemulsion droplets of 7 µm.

[0065] 2) The single-emulsion droplet system obtained in step 1) is stored in a refrigerator at 5° C. for 40 minutes, and the single-emulsion droplet evolves into a double-emulsion droplet. Then, under the environment of 15° C., the solvent in the double emulsion droplets was completely e...

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Abstract

The invention discloses a magnetic single-hole hollow nanosphere and a preparation method and application thereof. The nanosphere is a hollow ball body; the ball wall of the hollow ball body is assembled with magnetic nanoparticles and polyethylene glycol, and a single hole is formed in the surface of the ball wall. The preparation method comprises the steps that a disperse phase containing the magnetic nanoparticles and a continuous phase containing surfactant are injected into different channels of a micro-fluidic chip separately, and the disperse phase is sheared into a high monodisperse magnetic single emulsion liquid drop by the continuous phase in the micro-fluidic chip; then the liquid drop is preserved at the low temperature and evolved into double emulsion liquid drops; subsequently, after solvent in the double emulsion liquid drops is volatilized completely, washing is conducted, and the intelligent magnetic single-hole hollow nanosphere is obtained. The magnetic single-hole hollow nanosphere can be used as an intelligent carrier, and multiple biomedical functions including controllable loading and releasing, targeting, tracing and magnetic thermotherapy are integrated and achieved simultaneously.

Description

technical field [0001] The invention belongs to the field of inorganic nanometer materials, and relates to a magnetic single-hole hollow nanosphere and its preparation method and application. Background technique [0002] With the development of nanotechnology, the design and synthesis of nanometer-sized single-hole hollow spheres have received extensive attention in recent years, and have become a hot research field in the frontiers of chemistry, medicine, materials and other disciplines. Due to their unique cavity structure, these hollow nanospheres have low density and high specific surface area. And the larger internal cavity can be used to load a large number of functional and sensitive substances, such as loading drug molecules, catalysts, cosmetics, DNA, proteins, biochemical enzymes, etc. In addition, the inner cavity can also be used as a microreactor, allowing certain specific reactions to take place in it. In addition, due to its low density and high specific su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/12A61K49/18A61K47/02A61K47/34A61K41/00A61K31/704A61P35/00B01J13/02
CPCA61K31/704A61K47/02A61K47/10A61K49/126A61K49/1818B01J13/02
Inventor 姚立王秀瑜
Owner INST OF CHEM CHINESE ACAD OF SCI
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