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A kind of hemostatic and antibacterial Chinese herbal medicine toothpaste

A Chinese herbal medicine toothpaste, hemostasis and antibacterial technology, applied in the direction of antibacterial drugs, dentistry, drug combination, etc., can solve the problems of easy to reduce the self-healing ability of oral tissues, poor targeting of antibacterial active ingredients, low content of active ingredients, etc., to promote platelets Adhesion and aggregation, improving anti-sensitivity, treating and preventing gingival inflammation

Inactive Publication Date: 2018-09-14
GUANGXI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a hemostatic and antibacterial Chinese herbal medicine toothpaste to solve the problem that the existing traditional Chinese medicine toothpaste contains many traditional Chinese medicine prescriptions and complex composition, resulting in low content of active ingredients; the antibacterial active ingredients are poorly targeted, and long-term use can easily reduce the effect of various oral tissues on the toothpaste. Damage self-healing ability and other issues

Method used

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  • A kind of hemostatic and antibacterial Chinese herbal medicine toothpaste
  • A kind of hemostatic and antibacterial Chinese herbal medicine toothpaste
  • A kind of hemostatic and antibacterial Chinese herbal medicine toothpaste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0043] Example 4 In vitro hemostasis experiment

[0044] 1 Materials and methods

[0045] 1.1 Preparation of anticoagulant blood: take blood from rabbit ear vein, and mix it gently with 3.8% sodium citrate solution at a volume ratio of 9:1. Centrifuge the anticoagulated blood at 1000r / min for 10min to prepare platelet-rich plasma, and centrifuge at 3000r / min for 10min to prepare platelet-poor plasma.

[0046] 1.2 Preparation of sample solution

[0047] Prepare 2 mg / mL Chinese herbal medicine toothpaste sample solutions 1-3 in Examples 1-3, blank paste liquid, Yunnan Baiyao toothpaste liquid, and Liangmianzhen toothpaste liquid for nourishing gums and protecting teeth.

[0048] 1.3 Determination of plasma calcium coverage time (RT)

[0049] Mix 0.1mL normal saline and 0.1mL platelet-rich plasma in a centrifuge tube, add 0.1mL CaCl with a mass fraction of 0.2775% in a water bath at 37°C 2 Mix the solution and start timing, and stop timing when a white filament is produced. ...

Embodiment 5

[0066] The clinical hemostasis experiment of embodiment 5 mice

[0067] 2 Materials and methods

[0068] 2.1 The hemostasis clinical experiment used blank paste, Yunnan Baiyao toothpaste, Liangmianzhen toothpaste for nourishing gums and toothpaste with Chinese herbal medicine in Examples 1-3 as test samples.

[0069] 2.2 It is carried out by observing the hemostasis of local wound wounds in mice. Take 108 healthy Kunming mice, weighing 18-22 g, both male and female. After anesthetizing the mouse, use surgical scissors to cut off the left lobe of the liver with a length of about 0.5 cm, a width of about 0.5 cm, and a height of about 0.5 cm. After wiping off the sprayed blood, immediately apply 0.5 g of the sample to be tested on the face , oppressed with 200g weight for 1min, remove the weight after 1min, observe the hemostatic effect, until no bleeding. If bleeding still occurs, pressurize after applying the sample to be tested, observe once every 30s, and record the hemost...

Embodiment 6

[0073] Embodiment 6 in vitro antibacterial experiment

[0074] 3 Materials and methods

[0075] 3.1 Experimental bacteria: 2 common oral pathogenic bacteria were selected: Streptococcus mutans (25175), Porphyromonas gingivalis (33277), Guangdong Microbial Culture Collection Center. Medium: BHI liquid medium, CDC anaerobic agar medium.

[0076] 3.2 The MIC and MBC of the test samples against bacteria were determined by the double dilution method. Bacterial suspension preparation: Streptococcus mutans and Porphyromonas gingivalis were resuscitated for 48 hours, inoculated in BHI liquid medium, 37 ° C in 85% N2 , 10%H 2 , 5%CO 2 After culturing in an anaerobic incubator for 24 hours under certain conditions, the bacterial growth reached the logarithmic phase at this time. After the smear microscopic examination showed pure culture, the bacterial liquid was collected and the bacterial concentration was adjusted to 1.0×10 5 ~1.0×10 6 CFU / mL, spare.

[0077] 3.3 Preparation of...

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Abstract

The invention discloses hemostatic antiseptic traditional Chinese medicinal herbal toothpaste, and belongs to the technical field of traditional Chinese medicinal herbal toothpaste preparation. The toothpaste is prepared from the following raw materials in percentage by weight: 1-3 percent of traditional Chinese medicinal herbs, 64.8-66.1 percent of auxiliaries and the balance of deionized water, totally 100 percent. The toothpaste is prepared by extracting traditional Chinese medicinal herbs, mixing with auxiliaries and other steps. The toothpaste has the effects of relieving bleeding, inhibiting bacteria, diminishing inflammation, relieving pain and the like, can form a protective film on gingivae to protect the gingivae for a long time and improve the sensitivity resistance of gingivae, so that gingival inflammation can be radically treated and prevented. Compared with common chemical toothpaste, the traditional Chinese medicinal herbal toothpaste has the advantages that the smell is good, dental caries, gingival bleeding and other dental problems can be remarkably alleviated, relieved and prevented when the toothpaste is used for a long time.

Description

【Technical field】 [0001] The invention relates to a toothpaste for auxiliary treatment of oral inflammation, in particular to a Chinese herbal medicine toothpaste with hemostatic and antibacterial properties. 【Background technique】 [0002] Among oral diseases, periodontal disease and dental caries are common and frequently-occurring diseases in the human oral cavity, and the growth of oral bacteria is the main factor causing such diseases. Usually, by adding functional ingredients in the toothpaste, the toothpaste has the function of assisting in the prevention, prevention and alleviation of oral problems or has a certain improvement effect on the condition of the teeth. [0003] There are many factors that affect gingival bleeding, and a large part of the reason is caused by inflammation caused by oral anaerobic bacteria. Porphyromonas gingivalis are representative bacteria of the two types of bacteria in the oral cavity. Streptococcus mutans (Streptococcus mutans) is on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/9761A61Q11/00A61P1/02A61P31/04A61P7/04
CPCA61K8/97A61K36/14A61K36/232A61K36/282A61K36/537A61K2800/28A61K2800/524A61Q11/00A61K2300/00
Inventor 廖丹葵宋瑾林钻煌覃青云伍善广李玲许静杨卫豪黄光伟孙建华周利琴黄华来卢凯玲廖彭莹孙丽霞
Owner GUANGXI UNIV
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