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Preparation method of traditional Chinese medicine granules for treating infantile diarrhea

A technology for traditional Chinese medicine granules and infantile diarrhea, which is applied to pharmaceutical formulas, medical preparations containing active ingredients, and drug combinations, etc., can solve problems such as inconvenience for infants and young children to take, and achieve the effects of convenient taking, improving taking compliance and remarkable curative effect.

Inactive Publication Date: 2016-04-13
惠州市九惠制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Rotavirus infection is common in infants and young children, but currently there is no drug on the market for the effective treatment of rotavirus infection developed for infants; the applicant previously applied for a patent "A Traditional Chinese Medicine Composition for the Treatment of Diarrhea" (Patent No.: 200510086806.8) Although it has the effect of treating rotavirus infection, its original capsule dosage form is not convenient for infants to take, so this method develops Lianfan Zhixie Capsules into granules that are convenient for infants to take, improving the compliance of taking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take Coptis chinensis, add 85% ethanol solution with a volume and mass ratio of 5 times each time, heat and reflux at 70°C for 3 times, each time for 2 hours, filter, combine the filtrates, recover ethanol from the filtrate under reduced pressure, and dry at 60°C. Grind into fine powder A and set aside; take Scutellaria baicalensis, white peony root, patchouli, guava leaves, and poria cocos, add water with a volume-to-mass ratio of 10 times, decoct at 80°C for 4 hours, decoct twice in total, and combine the decoctions , filter, the filtrate is concentrated under reduced pressure to a relative density of 1.10, dried at 50°C, ground into fine powder B, and set aside; the following raw materials in parts by weight form a kind of granule manufacturing prescription suitable for children to take for the treatment of diarrheal diseases: get 16% Tartaric acid, 9% stevioside, 3% aspartame, 20% sucrose, and 18% lactose are crushed, added with 8% of material A and 26% of material B...

Embodiment 2

[0030] Take Coptis chinensis, add 55% ethanol solution of 8 times the volume to mass ratio each time, heat and reflux at 65°C for extraction once, each time for 4 hours, filter, combine the filtrates, recover ethanol from the filtrate under reduced pressure, and dry at 80°C. Grind into fine powder A and set aside; take Scutellaria baicalensis, white peony root, patchouli, guava leaves, and poria cocos, add water with a volume-to-mass ratio of 14 times, decoct at 90°C for 3 hours, decoct 3 times in total, and combine the decoction , filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.16, dried at 50°C, ground into fine powder B, and set aside; the following raw materials in parts by weight form a prescription for the manufacture of granules suitable for children to take for the treatment of diarrheal diseases: get 8% Citric acid, 4.5% stevioside, 1% aspartame, 0.5% sucralose, 10% sucrose, 42% starch, crushed, added 8% A material, 26% B m...

Embodiment 3

[0032] Take Coptis chinensis, add 65% ethanol solution with a volume and mass ratio of 5 times each time, heat and reflux at 70°C for 4 times, each time for 2 hours, filter, combine the filtrates, recover ethanol from the filtrate under reduced pressure, and dry at 75°C. Grind into fine powder A and set aside; take Scutellaria baicalensis, Radix Paeoniae Alba, Patchouli, Guava leaves, Poria cocos, add 12 times the volume to mass ratio of water, decoct at 85°C for 4 hours, decoct once in total, and combine the decoction , filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.13, dried at 50° C., ground into fine powder B, and set aside; the following raw materials in parts by weight form a granule manufacturing prescription suitable for children to take for the treatment of diarrheal diseases: get 12% Sodium bicarbonate, 9% stevioside, 2% aspartame, 15% sucrose, and 28% dextrin are pulverized, added with 8% of material A and 26% of materia...

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Abstract

The invention relates to the field of me pharmaceutical preparations, in particular to a preparation method of traditional Chinese medicine granules for treating infantile diarrhea. The preparation method of the traditional Chinese medicine granules for treating infantile diarrhea includes the steps: (1) extracting, concentrating and drying rhizoma coptidis, and grinding into fine powder A for standby application; (2) extracting, concentrating and drying radix scutellariae, radix paeoniae alba, herba pogostemonis, folium psidii guajavae and poria cocos, and grinding into fine powder B for standby application; (3) grinding, by weight, 8-16% of sour agent, 16-32% of sweetening agent and 18-42% of diluents, adding 6-10% of the fine powder A and 20-30% of the fine powder B, well mixing, and performing dry granulation to obtain the granules. The granules are effective in treatment of infantile rotavirus infectious diarrhea, and the bitter taste of the rhizoma coptidis in raw medicinal materials can be covered effectively to improve medicine taking compliance of infants; in addition, simplicity and reliability in production process and suitableness for industrial production are realized.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of traditional Chinese medicine granules for treating infantile diarrhea. Background technique [0002] Diarrhea is a common symptom and a group of gastrointestinal diseases that are widely prevalent all over the world, with a high incidence and serious harm. Billions of people suffer from the disease every year all over the world, and both adults and children have a higher incidence rate. According to WHO statistics, hundreds of millions of children under the age of five suffer from diarrhea every year in the world, resulting in the death of five million children. According to domestic statistics, the cause of death in children due to diarrhea ranks fourth among the common causes of death in children, which has attracted the attention of the World Health Organization and domestic health circles. There are many modern studies on the etiology, di...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/16A61P1/12
Inventor 刘强黄辉球
Owner 惠州市九惠制药股份有限公司
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