A Method for Testing Memory, Judgment, and Executive Ability of Primates

A primate, executive ability technology, applied in applications, other equipment, animal husbandry, etc., can solve the problems of researching human Parkinson's disease, Alzheimer's disease, different, high, immune response similar to human , to achieve the effect of reliable experimental results, fast response and easy memory

Active Publication Date: 2018-02-13
广西南宁灵康赛诺科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, ethological methods for studying animal memory, judgment, and execution have been established. A large number of related studies have been done on rodent (such as mice) models for Parkinson's disease and Alzheimer's disease. However, due to rodent There are great differences in the genetic structure and physiological functions of the brains of animals and humans, which makes the behaviors of rodents and humans significantly different, which has a great impact on the study of human Parkinson's disease and Alzheimer's disease. big obstacle
Non-human primates have many similarities with humans in terms of genetic structure and physiological functions. Humans have high gene homology, and their immune response is similar to that of humans. Among all animals, their physiological and biochemical indicators are the most similar to humans. Research on primates Animal memory, judgment and executive ability have important application value, but there are few relevant literature reports at present

Method used

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  • A Method for Testing Memory, Judgment, and Executive Ability of Primates

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Embodiment Construction

[0033] The present invention will be further described below in conjunction with specific examples, but the protection scope and application scope of the present invention will not be limited.

[0034] 1. Experimental animals

[0035]The present invention adopts 20 healthy old age cynomolgus monkeys, wherein 10 female monkeys, 10 male monkeys, age 10-15 (average 12.5) years old, through routine quarantine and physical examination, no limb damage, normal behavior habits of animals are complete, check The report includes clinical examination and laboratory examination content, which are all implemented according to national standards and provided by Guangxi Xiongsen Primate Breeding and Breeding Center. In the later stage of the experiment, 10 cynomolgus monkeys were injected with MPTP at a dose of 0.2mg / kg to obtain a stable early hemiparkinsonian animal model mimicking human Parkinson's disease. The company's AAALAC (Association for Assessment and Accreditation of Laboratory ...

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Abstract

The present invention discloses a method for testing memory, judgment and execution capabilities of a primate. The method comprises the following steps that: a testing device is disposed before a primate, the testing device is connected to a monitoring computer (20), and monitoring software is started; and the monitoring computer (20) automatically records the result tested every time and stores the test results in corresponding storage paths as data files. The present invention also discloses a structure of the testing device. By adoption of the testing device, the primate is liable to understand test schemes, and domestication success rate is high; behaviors such as reaction capability and arm and finger agility of the primate can be monitored conveniently, and automation requirements of data acquisition can be satisfied; and the method has the advantages that accuracy of experimental data is high, reaction speed is fast, and jamming is prevented.

Description

technical field [0001] The invention belongs to the field of animal cognitive behavior ability testing, and in particular relates to a method for testing memory, judgment and execution abilities of primates. Background technique [0002] Parkinson's disease is a chronic disease of the central nervous system that affects patients' mobility. It mostly occurs in middle-aged and elderly people. The main early manifestations include resting tremor, muscle rigidity, slow movement, difficulty in starting movements, and abnormal posture. Resting tremor, uncontrollable shaking of the patient's hands or arms, that occurs at rest or worsens with emotional stress; other early symptoms include difficulty starting activities, followed by frequent tremors in the arms and legs, and loss of fine motor movements in the upper extremities , resulting in inability to take care of oneself in daily life, such as difficulty in dressing, taking off shoes, and washing. The incidence rate of this dise...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K29/00
CPCA01K29/005
Inventor 岳峰韦伟
Owner 广西南宁灵康赛诺科生物科技有限公司
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