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Chitosan-salvia miltiorrhiza injection and preparation method thereof

A technology of Danshen injection and sugar salvia, which is applied in the direction of medical formulas, medical preparations with no active ingredients, and medical preparations containing active ingredients. Improve curative effect, protect form and function

Active Publication Date: 2016-03-30
广州市番禺区中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the existing problems of fallopian tube re-adhesion and low pregnancy rate after interventional recanalization of fallopian tubes. We have developed a new drug that can solve the problem of re-adhesion of fallopian tubes after interventional recanalization of fallopian tubes, namely compound Chitosan Danshen injection, it can prevent fallopian tube re-adhesion, promote tissue repair, prevent fallopian tube re-adhesion, improve fertilization success rate and increase intrauterine pregnancy rate; and good tissue compatibility, biodegradable, and has Functions and advantages of protecting normal fallopian tube epithelial cells, repairing damaged fallopian tube epithelial cells, preventing tissue adhesion, broad-spectrum antibacterial, improving local internal environment, and promoting fertilization

Method used

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  • Chitosan-salvia miltiorrhiza injection and preparation method thereof
  • Chitosan-salvia miltiorrhiza injection and preparation method thereof
  • Chitosan-salvia miltiorrhiza injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 prepares compound chitosan salvia miltiorrhiza injection preparation

[0063] The preparation method is as follows:

[0064] S1. Precisely measure 2ml of medical chitosan and 10ml of Danshen injection with a pipette, put them in the same 10ml glass test tube according to the ratio of 1:5 (v / v), vortex on an automatic vortexer for 10min, to mix the two evenly;

[0065] S2. Add an appropriate amount of polymer suspending agent (methyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose or povidone), shake in a water bath at 38°C for 45 minutes, and make it fully mixed to form a stable mixture. suspended state;

[0066] S3. Adding a concentration of 5% sodium bicarbonate solution to the solution in step S2 to adjust the pH to between 7.5 and 7.8 to obtain the compound chitosan salvia injection preparation; the concentration is 5% sodium bicarbonate solution The amount added is 1% of the total volume of the solution.

Embodiment 2

[0067] Embodiment 2 prepares compound chitosan and salvia miltiorrhiza injection preparation

[0068] The preparation method is as follows:

[0069] S1. Precisely measure 2ml of medical chitosan and 6ml of Danshen injection with a pipette, put them in the same 10ml glass test tube according to the ratio of 1:3 (v / v), and vortex on an automatic vortexer for 5min. to mix the two evenly;

[0070] S2. Add an appropriate amount of polymer suspending agent sodium carboxymethyl cellulose, shake in a water bath at 35°C for 60 minutes, make it fully mixed, and form a stable suspension state;

[0071] S3. Adding a concentration of 5% sodium bicarbonate solution to the solution in step S2 to adjust the pH to between 7.6 and 7.7 to obtain the compound chitosan salvia injection preparation; the concentration is 5% sodium bicarbonate solution The amount added is 1% of the total volume of the solution.

Embodiment 3

[0072] Embodiment 3 prepares compound chitosan and salvia miltiorrhiza injection preparation

[0073] The preparation method is as follows:

[0074] S1. Precisely measure 2ml of medical chitosan and 12ml of Danshen injection with a pipette, put them in the same 10ml glass test tube according to the ratio of 1:6 (v / v), and vortex on an automatic vortexer for 15min. to mix the two evenly;

[0075] S2. Add an appropriate amount of polymer suspending agent hydroxypropyl cellulose, and shake in a water bath at 40°C for 30 minutes to make it fully mixed to form a stable suspension state;

[0076] S3. Adding a concentration of 5% sodium bicarbonate solution to the solution in step S2 to adjust the pH to between 7.5 and 7.8 to obtain the compound chitosan salvia injection preparation; the concentration is 5% sodium bicarbonate solution The amount added is 1% of the total volume of the solution.

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Abstract

The present invention discloses a chitosan-salvia miltiorrhiza injection preparation and a preparation method thereof. According to the present invention, the compound chitosan-salvia miltiorrhiza injection preparation is prepared by mixing medical chitosan and a salvia miltiorrhiza injection; specifically medical chitosan and a salvia miltiorrhiza injection are subjected to uniform vortex mixing, a right amount of a synthetic or semi-synthetic polymer auxiliary suspending agent is added, water bath shaking is performed to form a stable suspending state, a sodium bicarbonate solution is added, and the pH value is adjusted to 7.5-7.8 so as to obtain the compound chitosan-salvia miltiorrhiza injection preparation; and the chitosan-salvia miltiorrhiza injection preparation is used for uterine tubeinterventional recanalization, can prevent uterine tube postoperative adhesion and promote tissue repair, and provides important effects for prevention of uterine tube re-adhesion, improvement of uterine tube smooth muscle functions, improvement of uterine tube internal environment and microcirculation, adjustment of the pH value, improvement of the fertilization success rate, and improvement of the intrauterine pregnancy.

Description

technical field [0001] The invention belongs to the technical field of gynecological interventional medicine. More specifically, it relates to a compound chitosan salvia injection preparation and a preparation method thereof. Background technique [0002] Interventional recanalization refers to interventional recanalization of fallopian tubes. In 1985, American doctor Platia first reported the use of catheter interventional therapy for tubal obstruction. Since then, researches on interventional recanalization for tubal obstructive infertility have been carried out at home and abroad. The steps of this method are as follows: The operation is performed 3 to 7 days after menstruation is clean, intramuscular injection of promethazine 25mg for sedation 0.5h before operation, and intramuscular injection of atropine 0.5mg to prevent fallopian tube spasm; under the fluoroscopy of digital subtraction X-ray machine, the front end of the balloon is sent to the uterus In the neck or ut...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K9/08A61P15/08A61P41/00A61K31/192A61K31/11
CPCA61K9/0019A61K9/08A61K31/11A61K31/192A61K31/722A61K47/32A61K47/38A61K2300/00
Inventor 黄晨陈汉威黄益杨辉苏健芬唐郁宽王皓佐衡郭惠庄庄炜钊
Owner 广州市番禺区中心医院
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