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Application of proadifen in preparation of anti-inflammation drugs

A drug and inflammation technology, applied in the field of medicine, can solve the problems of no anti-inflammatory activity and anti-inflammatory target activity of prodiphene, and achieve the effects of good development prospects, promotion of neutrophil regression, and wide source of raw materials

Inactive Publication Date: 2016-03-30
HANGZHOU LEISUO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there have been no relevant reports on the anti-inflammatory activity and anti-inflammatory target activity of prodifine

Method used

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  • Application of proadifen in preparation of anti-inflammation drugs
  • Application of proadifen in preparation of anti-inflammation drugs
  • Application of proadifen in preparation of anti-inflammation drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example Quantitative observation of anti-inflammatory drug effect of single concentration prodifine hydrochloride in zebrafish inflammation model

[0020] Zebrafish:

[0021] The zebrafish used in this example was MPO-GFP zebrafish, and the breeding and use standards were strictly in accordance with the requirements of the American Laboratory Animal Care and Use Committee (IACUC).

[0022] Fishwater:

[0023] Configuration method: Add 0.3g of sea salt (InstantOceansalts) to 1L of reverse osmosis (RO) water.

[0024] Dimethyl sulfoxide (DMSO, analytically pure):

[0025] Purchased from Aladdin (Catalog #1095515, Lot #30573). 1% DMSO solution (negative control) preparation: When in use, prepare a working solution with a concentration of 1.0% with fish farming water, and prepare it immediately for use.

[0026] Copper Sulfate (Inducer):

[0027] Purchased from Xilong Chemical Co., Ltd., batch number 069H155. When in use, use 0.1% DMSO solution to prepare the concentr...

Embodiment 2

[0042] Example 2 Quantitative observation of the anti-inflammatory drug effect of multi-concentration prodifine hydrochloride in zebrafish inflammation model

[0043] The experimental method is the same as in Example 1. In a 12-well plate, 15 fish per well, 1ml of fish water, observe the anti-inflammatory drug effect of prodifine hydrochloride in the copper sulfate-induced zebrafish inflammation model at 10, 30, and 100 μM concentrations And toxicity performance, zebrafish body bends and dies at a concentration of 100 μM, indicating that this concentration is toxic. There is no obvious toxic phenotype at the concentration of 10 and 30 μM, and the anti-inflammatory treatment efficiency is 27.8% (p<0.05) and 35.2% (p<0.01), respectively, indicating that prodifine hydrochloride has significant anti-inflammatory effects in non-toxic concentrations , and the dose-effect relationship is clear.

[0044] Table 2 Anti-inflammatory efficacy of prodifine hydrochloride in copper sulfate-...

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Abstract

The invention belongs to the technical field of drugs, and concretely relates to an application of proadifen and pharmaceutically acceptable salts thereof in the preparation of inflammation associated disease prevention and treatment drugs. Above inflammations comprise aseptic inflammations and immune inflammations. The use of proadifen in the preparation of anti-inflammation drugs is disclosed in the invention for the first time, and a result of copper sulfate induced zebra fish inflammation model experiment researches shows that proadifen can promote regression of neutral granulocytes in the inflammation positions, and has inflammation prevention and elimination effects. The proadifen has obvious an anti-inflammatory effect on inflammation associated diseases, and can be used to prepare the inflammation associated disease prevention and treatment drugs.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of prodifine and pharmaceutically acceptable salts thereof in the preparation of medicines for preventing and treating inflammation-related diseases. Background technique [0002] Inflammation is a beneficial host response to invading pathogens or sterile tissue damage. Inflammatory response is a result of the joint action of cells and inflammatory mediators in time and space to neutralize or eliminate damage stimuli to maintain homeostasis. Although inflammation is primarily a physiological and beneficial process, unresolved inflammatory processes contribute to the development of many inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, asthma, psoriasis, systemic lupus erythematosus, multiple sclerosis , systemic vasculitis, atherosclerosis, rhinitis, etc. [0003] For the treatment of inflammation, glucocorticoid anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P29/00A61P37/02A61P19/02A61P19/08A61P1/00A61P13/08A61P11/00A61P11/02A61P11/04A61P1/18A61P11/06A61P17/06
Inventor 李春启周娟宋如顺高羽军吴耀东
Owner HANGZHOU LEISUO PHARMA
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