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Application of 3,5-di-tert-butyl copper salicylate in the preparation of drugs for the treatment of highly metastatic breast cancer

A technology of copper di-tert-butyl salicylate and high transfer, applied in the field of medicine, can solve problems such as the specific application of undisclosed chelate compounds, and achieve the effects of ensuring industrialized production, high purity and wide sources

Active Publication Date: 2018-05-22
JIANGHAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported in the prior art that certain chelates of the trace element Cu include copper 3,5-diisopropyl salicylate Cu 2 (3,5-dips) 2 It has an inhibitory effect on the promotion and formation of tumors, but the specific application of the chelate has not been disclosed, so further research is required for clinical application

Method used

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  • Application of 3,5-di-tert-butyl copper salicylate in the preparation of drugs for the treatment of highly metastatic breast cancer
  • Application of 3,5-di-tert-butyl copper salicylate in the preparation of drugs for the treatment of highly metastatic breast cancer
  • Application of 3,5-di-tert-butyl copper salicylate in the preparation of drugs for the treatment of highly metastatic breast cancer

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Embodiment Construction

[0020] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0021] Effect of copper 3,5-di-tert-butylsalicylate on the metastatic ability of MDA-MB-231 and BT-20 cells

[0022] 1. Experimental materials

[0023] 1.1 Cell lines

[0024] Human breast cancer cell lines MDA-MB-231 and BT-20 were purchased from China Center for Type Culture Collection (CCTCC).

[0025] 1.2 Drugs and reagents

[0026]

[0027]

[0028] 2. Experimental method:

[0029] 2.1 Cell culture

[0030] Human highly metastatic breast cancer cell line MDA-MB-231 was incubated with 1640 culture medium containing 10% FBS, 100 μg / ml penicillin, and 100 μg / ml streptomycin at 37°C, CO 2 Cultured in a cell incubator with a volume fraction of 5%.

[0031] 2.2 "Scratch healing" method to detect the effect of different concentrations of drugs on the migration ability of MDA-MB-231 cells

[0032] Take MDA-MB-231 and BT-20 c...

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Abstract

The invention discloses the application of 3,5-di-tert-butyl copper salicylate in the preparation of medicines for treating highly metastatic breast cancer and the dosage of 3,5-di-tert-butyl copper salicylate. Experiments have proved that copper 3,5-di-tert-butyl salicylate can inhibit the metastasis of breast cancer cells, and inhibit the invasion of breast cancer cells in a concentration-dependent manner. The invention discovers a new medical application for 3,5-di-tert-butyl copper salicylate, and opens up a new application field.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of copper 3,5-di-tert-butyl salicylate in the preparation of medicines for treating highly metastatic breast cancer. Background technique [0002] Breast cancer is by far the most common cancer among women worldwide. About 500,000 people die from breast cancer every year in the world, which poses a serious threat to women's life and quality of life. Breast cancer has also become the most common cancer among Chinese women; the annual number of new breast cancer cases and deaths in China account for 12.2% and 9.6% of the world's total respectively. With the acceleration of the pace of life and the aggravation of work pressure, breast cancer patients are showing a trend of younger age and higher incidence. At present, the treatment of breast cancer mainly adopts surgical resection and chemotherapy, but for highly metastatic breast cancer, none of the existing trea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/60A61P35/00
CPCA61K31/60
Inventor 徐金华柳昀熠范丽梅童玉华
Owner JIANGHAN UNIVERSITY
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