Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for improving anaerobic fermentation efficiency of antibiotic drug residues containing sporophore

A technology of antibiotic dregs and anaerobic fermentation, which is applied in the direction of fermentation and fungi, and can solve the problems of low organic load of anaerobic fermentation of cephalosporin dregs, mismatch between processing capacity and output, and inability to meet processing requirements, etc. Achieve the effects of shortening the processing time, increasing the biogas production, and simple implementation

Active Publication Date: 2016-03-16
BIOLOGY INST OF HEBEI ACAD OF SCI
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some pharmaceutical companies took the lead in carrying out anaerobic fermentation treatment of dregs and achieved initial results, there are still many problems. One of the key problems is that the main component of dregs of cephalosporins is not mycelium, but fungal differentiation. Sporozoites are extremely difficult to break the wall, resulting in low organic load of anaerobic fermentation of cephalosporin dregs, unstable system operation, serious mismatch between processing capacity and production volume, far from meeting processing needs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Biogas production test by anaerobic fermentation: using 250mL anaerobic bottle, fully mixed anaerobic fermentation process, with 2 treatments:

[0018] Treatment 1: Cephalosporin C dregs were used as raw materials without any treatment, as a control;

[0019] Treatment 2: Use cephalosporin C dregs cultivated for 10 hours as raw material (the culture medium is 0.3% glucose aqueous solution, pH value 7.0-7.2, the amount of dregs added is 50% (v / v), and the culture temperature is 35± 2°C).

[0020] The organic load TS is 2%, (TS is also called the dry matter concentration, which refers to placing a certain amount of fermentation feed liquid in an oven at 100-105 °C and drying it to a constant weight, and the percentage of the dried material to the total weight), with normal The biogas slurry in the fermentation biogas digester is the inoculum, the inoculum amount is 20-30% (volume ratio), the fermentation temperature: medium temperature (35±2) ℃, the fermentation time is ...

Embodiment 2

[0024] Biogas production test by anaerobic fermentation: using 250mL anaerobic bottle, fully mixed anaerobic fermentation process, with 6 treatments,

[0025] Treatment 1: use cephalosporin C dregs as raw material, without any treatment, as a control;

[0026] Treatment 2: Use cephalosporin C dregs cultivated for 8 hours as raw material (the culture medium is 0.5% glucose aqueous solution, pH value 7.0-7.2, the amount of dregs added is 60% (v / v), and the culture temperature is 27± 2°C);

[0027] Treatment 3: Ultrasonic treatment of medicinal residues for 30 minutes (ultrasonic sound density: 0.6W / mL);

[0028] Treatment 4: ultrasonically treat the dregs cultivated in Treatment 2 for 30 minutes;

[0029] Treatment 5: Microwave treatment of medicinal residues for 2 minutes (power: 575W);

[0030] Treatment 6: Microwave the medicinal residues cultured in Treatment 2 for 2 minutes.

[0031] The organic load TS is 3%, (TS is also called the dry matter concentration, which refer...

Embodiment 3-7

[0036] Biogas production test by anaerobic fermentation: use 250mL anaerobic bottle, fully mixed anaerobic fermentation process, culture temperature of cephalosporin C dregs at 30±2°C, use biogas slurry in normal fermentation digester as inoculum, inoculum size 20 -30% (volume ratio), fermentation temperature 25-35°C, fermentation time 50d, each treatment was used as 5 parallels. The results are shown in Table 3. Anaerobic fermentation was performed on the cultivated cephalosporin C dregs, and the biogas production rate was significantly higher than that of the control. There was no significant difference in the average methane content of different treatments.

[0037] Table 3 Example 3-7 Biogas Production Situation

[0038] .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for improving anaerobic fermentation efficiency of antibiotic drug residues containing sporophore. The method includes the step of anaerobic fermentation, and the step of culturing the antibiotic drug residues containing sporophore is further included before the step of anaerobic fermentation. Taking cephalosporin C drug residues for example, after the culture step is added, the yield of marsh gas is raised by 50% or more; the method can be further combined with ultrasound, microwave, thermokalite and the like for pretreatment, and the yield of marsh gas is also raised by 50% or more. By means of the method, the problems of recycling of a great number of antibiotic drug residues and environmental pollution can be solved, and the method has great significance in promoting sustainable development of the antibiotics pharmaceutical industry and protecting the ecological environment and has actual economic and social benefits and wide application prospect.

Description

technical field [0001] The invention relates to the technical field of biogas resource treatment of antibiotic dregs, in particular to a method for improving the anaerobic fermentation efficiency of sporophyte-containing antibiotic dregs, especially cephalosporin C dregs. Background technique [0002] my country is the world's largest producer and exporter of antibiotic raw materials. The production of 1 ton of antibiotics produces about 8 to 10 tons of wet fungal residues. Therefore, the annual discharge of antibiotic residues reaches millions of tons. The residual culture medium and antibiotics in antibiotic residues The parent body and its degradation products are potentially harmful to the ecological environment and human health. The country has clearly listed antibiotic dregs as hazardous waste and prohibited them from being used in feed and fertilizer. The disposal method approved by the current policy is mainly incineration, and the incineration of 1 ton of medicinal r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P35/06
Inventor 程辉彩习彦花张丽萍王慧何强王宏伟崔冠慧张根伟尹淑丽刘洪伟
Owner BIOLOGY INST OF HEBEI ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com