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Temperature-sensitive gel type nanometer silver aerosol and preparation method thereof

A temperature-sensitive gel and nano-silver technology, which can be used in aerosol delivery, pharmaceutical formulations, local antibacterial agents, etc., can solve the problems of high pressure resistance and low boiling point of containers, and achieve excellent curative effect, good permeability, and particle size small diameter effect

Inactive Publication Date: 2016-03-16
天津新济复兴药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the boiling point after liquefaction is very low, and the vapor pressure is too high at room temperature, so the requirements for the pressure resistance of the container are relatively high.

Method used

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  • Temperature-sensitive gel type nanometer silver aerosol and preparation method thereof
  • Temperature-sensitive gel type nanometer silver aerosol and preparation method thereof
  • Temperature-sensitive gel type nanometer silver aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation 1 of temperature-sensitive gel-type nano-silver foam aerosol:

[0032] Prepare temperature-sensitive gel-type nano-silver foam aerosol according to the following steps and corresponding component ratios:

[0033] Step 1. Accurately measure distilled water, place it in an ice-water bath, and slowly add accurately weighed Poloxamer 407 and Poloxamer 188 while stirring to make Poloxamer 407 and Poloxamer 188 The particles are wetted by water;

[0034] Step 2. Store the mixed solution in step 1 in a refrigerator at 4° C. until a clear, lump-free, and uniformly dispersed solution is obtained.

[0035] Step 3: Add nano-silver colloid, glycerin, and ethylparaben to the solution in step 2; stir and mix evenly to form a gel.

[0036] Wherein the proportioning ratio of each component is:

[0037]

[0038] Step 4, sub-packaging and canning the propellant dimethyl ether accounting for 10% of the volume ratio of the above-mentioned gel system after constant volume. ...

Embodiment 2

[0042] Preparation of temperature-sensitive gel-type nano-silver foam aerosol 2:

[0043] Prepare thermosensitive gel type nano-silver foam aerosol by the step in embodiment 1, the proportioning adjustment of each component is:

[0044]

[0045]

[0046] In step 4, the propellant dimethyl ether with a volume ratio of 8% can be filled, and the sources of various components used in the preparation process are the same as those in Example 1.

Embodiment 3

[0048] Preparation of temperature-sensitive gel-type nano-silver foam aerosol 3:

[0049] Prepare thermosensitive gel type nano-silver foam aerosol by the step in embodiment 1, the proportioning adjustment of each component is:

[0050]

[0051] In step 4, the propellant dimethyl ether with a volume ratio of 15% is filled in a tank, and the sources of various components used in the preparation process are the same as those in Example 1.

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Abstract

The present invention relates to a temperature-sensitive gel type nanometer silver gel aerosol, which contains a gel system and a propellant dimethyl ether uniformly mixed in the gel system, wherein the gel system contains silver nanoparticles, a temperature-sensitive macromolecule polymer and a diluent, and a volume of the propellant dimethyl ether to the gel system is 5-20%. According to the present invention, the sprayed material of the temperature-sensitive gel type nanometer silver gel aerosol is foam, the deep administration can be achieved, the drug can rapidly expand and contacts the lesion after the drug reaches the lesion, the drug is uniformly dispersed in the cavity channel, and the penetration is complete; the temperature-sensitive gel type nanometer silver gel aerosol forms the semi-solid gel in the special physiological environment of the administered part, the adhesion is strong, and the temperature-sensitive gel type nanometer silver gel aerosol is absorbed by vaginal mucosa so as to provide the effect; and the temperature-sensitive gel type nanometer silver gel aerosol has advantages of effective patient compliance improving, effective nanometer sliver bioavailability improving, easy use, exact treatment effect, and no drug dependence.

Description

technical field [0001] The invention relates to a medicine for treating and preventing gynecological diseases and a preparation method thereof, in particular to a gynecological thermosensitive gel-type nano-silver aerosol and a preparation method thereof. Background technique [0002] Nano-silver is an ultra-micro-sized material (usually 10-100nm) that emerged with the rise of nanotechnology and nanomaterial research. Due to quantum effects, small size effects and macroscopic tunnel effects, it has strong activity and tissue penetration. Power, its bactericidal effect is far stronger than ordinary silver and silver ions. Studies have shown that the antibacterial performance of nano-silver particles is far greater than that of traditional silver ion fungicides, such as silver nitrate and silver sulfadiazine, especially for the killing of pathogenic bacilli, cocci, and mycelium. In addition, from the analysis of the antibacterial mechanism of nano-silver, due to the surface e...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K9/12A61K47/08A61P31/02A61P15/00
Inventor 崔景柏吴传斌梁华辉
Owner 天津新济复兴药业科技有限公司
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