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Niclosamide ethanolamine self-emulsifying micro-emulsion and preparation method thereof

A niclosamide ethanolamine salt, self-emulsifying technology, applied in the directions of biocides, molluscicides, biocides, etc., can solve the problems that do not involve the use of self-micro-emulsifying technology, the actual effect and the lack of realization cost, etc., achieve the formula The method is simple and feasible, convenient for large-scale industrial production, and has the effects of high content of active ingredients.

Active Publication Date: 2016-03-16
镇江市疾病预防控制中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the above-mentioned patent involves the improvement of the dosage form of niclosamide ethanolamine salt, in order to achieve the purpose of improving drug solubility and water dispersibility, and convenient use, but there are deficiencies in actual effect and realization cost, and it does not involve the use of self-microemulsification technology to achieve the above objectives

Method used

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  • Niclosamide ethanolamine self-emulsifying micro-emulsion and preparation method thereof
  • Niclosamide ethanolamine self-emulsifying micro-emulsion and preparation method thereof
  • Niclosamide ethanolamine self-emulsifying micro-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Weigh 1.6g Tween 80 and 1.6g ethanol, and mix them evenly under the action of magnetic stirring.

[0029] (2) Add 0.8 g of isopropyl myristate to the mixed emulsifier prepared in step (1), and mix evenly under the action of magnetic stirring to obtain a blank self-emulsifying microemulsion.

[0030] (3) Finally, 0.1 g of niclosamide ethanolamine salt raw material was added, and stirred in a water bath at 40° C. until a uniform and transparent solution was formed to obtain a niclosamide ethanolamine salt self-emulsifying microemulsion.

Embodiment 2

[0032] (1) Weigh 2.8g of polyoxyethylene castor oil and 0.7g of ethanol, and mix them evenly under the action of magnetic stirring.

[0033] (2) Add 1.5 g of ethyl oleate to the mixed emulsifier prepared in step (1), and mix evenly under magnetic stirring to obtain a blank self-emulsifying microemulsion.

[0034] (3) Finally, 0.1 g of niclosamide ethanolamine salt raw material was added, and stirred in a water bath at 40° C. until a uniform and transparent solution was formed to obtain a niclosamide ethanolamine salt self-emulsifying microemulsion.

Embodiment 3

[0036] (1) Weigh 0.5g of polyoxyethylene hydrogenated castor oil and 0.75g of PEG400, and mix them evenly under the action of magnetic stirring.

[0037] (2) Add 1 g of ethyl butyrate to the mixed emulsifier prepared in step (1), and mix evenly under the action of magnetic stirring to obtain a blank self-emulsifying microemulsion.

[0038] (3) Finally, 0.1 g of niclosamide ethanolamine salt raw material was added, and stirred in a water bath at 100° C. until a uniform and transparent solution was formed to obtain a niclosamide ethanolamine salt self-emulsifying microemulsion.

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Abstract

The invention relates to the technical field of pharmacy and particularly relates to a pesticide niclosamide ethanolamine self-emulsifying micro-emulsion for killing oncomelania and a preparation method thereof. The niclosamide ethanolamine self-emulsifying micro-emulsion provided by the invention is prepared from niclosamide ethanolamine, an oil phase, an emulsifying agent and an auxiliary emulsifying agent, wherein the mass ratio of all the components is that the niclosamide ethanolamine to the oil phase to the emulsifying agent to the auxiliary emulsifying agent is 1 to (1-15) to (5-30) to (5-20). The niclosamide ethanolamine self-emulsifying micro-emulsion has the following beneficial effects: 1, the dissolving rate of the pesticide is greatly improved and the dispersity of the pesticide in a water body system is improved; 2, the product does not contain aromatic series organic solvents, and organic solvents which seriously pollute the environments, such as N-methyl pyrrolidone, dimethylformamide and cyclohexanone, the content of effective components is high and the transportation convenience is improved; and 3, the formula and the method are simple and feasible, special equipment is not needed and the large-scale industrial production is easy to realize.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a drug niclosamide ethanolamine salt self-emulsifying microemulsion for killing oncomelania and a preparation method thereof. Background technique [0002] Schistosomiasis is a major zoonotic parasitic disease that seriously endangers human health. Niclosamide ethanolamine salt (niclosamide ethanolaminesalt, NES) is the only molluscicide recommended by the World Health Organization. It achieves the purpose of blocking the infection route and eradicating schistosomiasis by killing the snails, the parasite of schistosomiasis, with excellent effect. However, the solubility of the drug is only 7.8 mg / L, and it belongs to the class of insoluble substances that are almost insoluble or insoluble, and its practical application is limited. In order to improve the water solubility of NES, it is mixed with carrier, filler, surfactant and other auxiliary materials to make 50% niclosamide e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/40A01N25/04A01P9/00
Inventor 易承学陈宏张明辉徐虹郝世轩仲志鸿曹文婷
Owner 镇江市疾病预防控制中心
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