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Medicine composition for treating leukemia and preparation method thereof

A leukemia and composition technology, applied in the field of leukemia drugs, can solve the problems of unfavorable leukemia treatment, liver and kidney damage, high concentration, etc., and achieve the effect of enhanced synergistic enhancement, curative effect improvement, and high extraction rate

Active Publication Date: 2016-03-02
YIFAN PHARM ACADEMY BEIJING CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Compound Huangdai Tablets needs to be taken in a relatively large dose to achieve the purpose of treating leukemia, but because the Compound Huangdai Tablets have relatively high toxicity, taking a large amount and taking it for a long time will cause great damage to the liver and kidneys
[0004] In addition, in the process of preparing the extract in the existing preparation process, the next process step cannot be carried out because the concentration is too high, which is very inconvenient
[0005] At the same time, the existing compound Huangdai tablets and retinoic acid (a drug for treating leukemia, often used together with arsenic to treat leukemia) will have certain cross-drug resistance, which is not conducive to the treatment of leukemia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] With realgar, Qingdai, Danshen, and Pseudostellaria as components, prepare realgar, Qingdai, Danshen, and Pseudostellaria according to the proportions of realgar 2%, Qingdai 42%, Danshen 50%, and Pseudostellaria 6%. ginseng;

[0044] Select the realgar, adopt the method of water flying, take the sediment after water flying, dry and finely grind it for later use;

[0045] First crush Pseudostellaria ginseng into the finest powder, then superfinely crush it into very fine powder, and sterilize it for later use;

[0046] Selected premium Qingdai powder, washed and refined, dried and sterilized for later use;

[0047] The fine powder of above-mentioned three medicine components is mixed for subsequent use;

[0048] Add 8 times the amount of water, decoct twice for 50 minutes each time, filter, combine the filtrates, and concentrate to a clear paste with a relative density of 1.15-1.24 (50°C) at a temperature of 48-54°C;

[0049] Add the mixed fine powder of the above thr...

Embodiment 2

[0051] With the four medicines of realgar, Qingdai, Danshen and Taizishen as components, the realgar, Qingdai, Danshen and Taizishen are prepared according to the proportions of realgar 8%, Qingdai 25%, Danshen 60%, and Taizishen 7%. ginseng;

[0052] Select the realgar, adopt the method of water flying, take the sediment after water flying, dry and finely grind it for later use;

[0053] First crush Pseudostellaria ginseng into the finest powder, then superfinely crush it into very fine powder, and sterilize it for later use;

[0054] Selected premium indigo naturalis powder, washed and refined, sterilized for later use;

[0055] The fine powder of above-mentioned three medicine components is mixed for subsequent use;

[0056] Danjiu 9 times the amount of water, decoct twice, 55min each time, filter, combine the filtrates, and concentrate at a temperature of 48-54°C to a clear paste with a relative density of 1.15-1.24 (50°C);

[0057] Add the mixed fine powder of the abov...

Embodiment 3

[0059] With realgar, Qingdai, Danshen and Pseudostellaria as components, prepare realgar, Qingdai, Danshen and Pseudostellaria according to the proportions of realgar 5%, Qingdai 27%, Danshen 58%, and Pseudostellaria 10%. ginseng;

[0060] Select the realgar, adopt the method of water flying, take the sediment after water flying, dry and finely grind it for later use;

[0061] First crush Pseudostellaria ginseng into the finest powder, then superfinely crush it into very fine powder, and sterilize it for later use;

[0062] Selected premium indigo naturalis powder, washed and refined, sterilized for later use;

[0063] The fine powder of above-mentioned three medicine components is mixed for subsequent use;

[0064] Add 8 times the amount of water, decoct twice, 55min each time, filter, combine the filtrates, concentrate to a thick paste at a temperature of 48-54°C, dry, and pulverize into fine powder;

[0065] Add the salvia miltiorrhiza powder into the mixed fine powder o...

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Abstract

The invention relates to the field of leukemia medicine, in particular to a medicine composition for treating leukemia and a preparation method thereof. The medicine composition is mainly prepared from, by weight, 2-8% of realgar, 25-42% of indigo naturalis, 50-60% of salviae miltiorrhizae and 6-10% of radix pseudostellariae. The preparation method of salviae miltiorrhizae is improved, the amount of water added to salviae miltiorrhizae is decreased, the number of decoction times is decreased, the decoction time is shortened, it is ensured that effective components of salviae miltiorrhizae are not damaged, the effective component tanshinone IIA for controlling indexes is detected through a high performance liquid chromatograph, the extraction rate reaches 75%, activity of all effective components is well kept, and the extraction rate is kept at a high level. When the medicine composite improved according to the prior art is used for treating leukemia clinically, the complete remission rate reaches 92.9%, the treatment effect is obviously increased and improved, and toxic and side effects are greatly reduced.

Description

technical field [0001] The invention relates to the field of leukemia drugs, in particular to a pharmaceutical composition for treating leukemia and a preparation method thereof. Background technique [0002] At present, there are more than 190 compound preparations containing realgar officially included in the current national standards of the four major traditional Chinese medicines, accounting for about 2.78% of all prescription preparations. Long-term use of traditional Chinese medicine preparations containing excessive amounts of realgar can easily lead to chronic arsenic poisoning, and even death cases, so excessive realgar should not be taken for a long time. Realgar "Chinese Pharmacopoeia" 2010 edition stipulates that the daily intake should not exceed 0.1g. If the human body takes large doses of realgar for a long time, it can lead to the accumulation of heavy metals such as arsenic in the body, causing serious damage to liver and kidney function, and may damage th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K36/704A61P35/02A61K33/36
CPCA61K9/28A61K33/36A61K36/195A61K36/315A61K36/36A61K36/537A61K36/704A61K2236/331A61K2236/39A61K2236/51A61K2300/00A61K36/19A61P35/02A61K36/70A61K9/2095A61K9/4833A61K36/15
Inventor 周文艳陈金林许云高
Owner YIFAN PHARM ACADEMY BEIJING CO LTD
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