Application of soft capsule containing sheep placenta, radix salviae miltiorrhizae and grape seeds in preparing cough medicine

A grape seed and sheep placenta technology, applied in capsule delivery, drug combination, pharmaceutical formula, etc.

Inactive Publication Date: 2016-02-24
WUHU NOKAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there is no Sheep Placenta Danshen Grape Seed Soft Capsules Have Antitussive Effect Report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] used as a cough suppressant Preparation of Sheep Placenta Danshen Grape Seed Soft Capsules

[0018] The main raw materials are sheep placenta freeze-dried powder, grape seed extract, salvia miltiorrhiza extract, soybean oil, beeswax, gelatin, and glycerin, which are processed by crushing, mixing, homogenizing, pelletizing, and drying.

[0019] The main quality indicators are as follows: the capsule skin is red, and the contents are reddish brown; it has a unique taste, smell, no peculiar smell, no peculiar smell; the contents are oily liquid. The content of protein ≥ 6.6g / 100g, the content of proanthocyanidins ≥ 3.6g / 100g.

Embodiment 2

[0021] Effect of Sheep Placenta Danshen Grape Seed Soft Capsule on Cough in Mice.

[0022] 1. Test materials.

[0023] 1.1 Animals

[0024] Kunming mice.

[0025] 1.2 Drugs

[0026] Sheep placenta Danshen grape seed soft capsule: prepared according to the method of Example 1.

[0027] 1.3 Data and statistics

[0028] The data are expressed as mean±s, and analyzed with SPSS11.0 software. The measurement data were statistically analyzed by one-way analysis of variance, and the enumeration data were analyzed by chi-square test.

[0029] 2. Methods and Results

[0030] 2.1 Effect on cough in mice

[0031] 60 mice, half male and half male, were randomly divided into 4 groups: blank control group; low, medium and high dose groups (1.20g / Kg, 2.40g / Kg, 4.80g / Kg). The mice were placed in an inverted 500ml beaker 1 hour after gavage administration, and cotton balls with 0.3ml of ammonia water were put in, and the cough latency of the mice and the number of coughs within 3 mi...

Embodiment 3

[0037] Clinical Observation of Sheep Placenta Danshen Grape Seed Soft Capsules in Treating Variant Cough and Variant Asthma

[0038] 1 Materials and methods

[0039] 1.1 General information: 62 outpatients with CVA were randomly selected, including 35 males and 27 females; aged 22 to 54 years; the course of disease ranged from 1 to 12 months, with 1 to 3 months being the most common. Sixty-two patients were randomly divided into a treatment group of 32 cases and a control group of 30 cases. There was no significant difference in gender, age, height, family genetic history and disease severity between the two groups (P>0.05).

[0040] 1.2 Diagnostic criteria

[0041] The patient's clinical manifestations were persistent and recurring cough for more than 1 month, especially at night or in the early morning, and the cough would worsen after exercise; the clinical chest X-ray and blood routine were normal, and There were no signs of infection; inhalation of albuterol aerosol ...

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PUM

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Abstract

The invention relates to an application method of a soft capsule containing sheep placenta, radix salviae miltiorrhizae and grape seeds, namely, an application of the soft capsule containing sheep placenta, radix salviae miltiorrhizae and grape seeds in preparing a cough medicine, and specifically, sheep placenta freeze-dried powder, grape seed extract, radix salviae miltiorrhizae extract, soybean oil, beewax, gelatin and glycerinum are adopted as raw materials, and subjected to the main procedures including smashing, mixing, homogenizing, pelleting, drying and the like to prepare the cough medicine. The cough medicine prepared by the soft capsule containing sheep placenta, radix salviae miltiorrhizae and grape seeds is significant in cough relieving effect, and has an obvious effect in alleviating the cough symptom of the cough variant asthma.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the technical field of traditional Chinese medicine antitussives. Background technique [0002] Cough variant asthma (CVA) refers to a special type of asthma with chronic cough as the main or only clinical manifestation, which belongs to atypical asthma. It is only coughing but not wheezing mainly because its wheezing threshold is higher than that of typical asthma. This kind of cough is often a long-term intractable dry cough (duration > 2 weeks), which often occurs at night or early morning paroxysmal cough, aggravated after exercise, and less sputum; often Induced by respiratory irritants (such as smoke), cold air, laughter, or coughing itself, deep inhalation or forced exhalation can also cause coughing, and there is no wheeze on physical examination. Due to insufficient understanding of CVA, it is often misdiagnosed as recurrent respiratory tract infection an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61K9/48A61P11/06A61P11/14A61K35/50
CPCA61K9/4875A61K35/50A61K36/537A61K36/87A61K2300/00
Inventor 许震
Owner WUHU NOKAN BIOTECH
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